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| 1 | Genetic barriers in transplantation medicine显示文摘The successful of transplantation is determined by the shared human leukocyte antigens(HLAs) and ABO blood group antigens between donor and recipient. In recent years, killer cell receptor [i.e., killer cell immunoglobulinlike receptor(KIR)] and major histocompatibility complex(MHC) class I chain-related gene molecule(i.e., MICA) were also reported as important determinants of transplant compatibility. At present, several different genotyping techniques(e.g., sequence specific primer and sequence based typing) can be used to characterize blood group, HLA, MICA and KIR and loci. These molecular techniques have several advantages because they do not depend on the availability of anti-sera, cellular expression and have greater specificity and accuracy compared with the antibody-antigen based typing. Nonetheless, these molecular techniques have limited capability to capture increasing number of markers which have been demonstrated to determine donor and recipient compatibility. It is now possible to genotype multiple markers and to the extent of a complete sequencing of the human genome using next generation sequencer(NGS). This high throughput genotyping platform has been tested for HLA, and it is expected that NGS will be used to simultaneously genotype a large number of clinically relevant transplantation genes in near future. This is not far from reality due to the bioinformatics support given by the immunogenetics community and the rigorous improvement in NGS methodology. In addition, new developments in immune tolerance based therapy, donor recruitment strategies and bioengineering are expected to provide significant advances in the field of transplantation medicine. | Hisham A Edinur Siti M Manaf Nor F Che Mat | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 2 | Acellular Muscle with Schwann-Cell Implantation: An Alternative Biologic Nerve Conduit显示文摘 | Hisham Fansa Gerburg Keilhoff Gerhard F?rster Bertolt Seidel Gerald Wolf Wolfgang Schneider | 1999 | J reconstr Microsurg1999，，07： | 2 |
| 3 | Total tyroidectomy : the Procedure of choice for muhinodular goiter显示文摘 | Hisham A N Azlilla A F Aina E N | 2001 | Eur J Surg2001，167，6： | 1 |
| 4 | Effect of the silica sources on the crystallinity of nanosized ZSM-5 zeolite显示文摘 | Reda M Mohamed Hisham M Aly Mohamed F El-Shahat | 2005 | Microporous and Mesuporous Materials2005，79，： | 1 |
| 5 | Structural parameters of collagen nerve grafts influence peripheral nerve regeneration显示文摘 | Felix S Hisham F Gerald W | 2005 | Biomaterials2005，26，16： | 1 |
| 6 | Structural parameters of collagen nerve grafts influence peripheral nerve regeneration显示文摘 | Hisham F Gerald W | 2005 | Biomaterials2005，26，： | 1 |
| 7 | Ano-coccygeal support in the treatment of idiopathic chronic posterior anal fissure:a prospective non-randomised controlled pilot trial显示文摘 | GEE T HISHAM R B JABAR M F | 2013 | Techniques in Coloproctology2013，17，2： | 1 |
| 8 | Effect of the silica sources on the crystallinity of nanosized ZSM-5 zeolite显示文摘 | Reda M M Hisham A M Mohamed E F | | 0，，： | 1 |
| 9 | Variation of the fracture toughness of concrete with temperature显示文摘 | Hisham A F Sameer A H | 1997 | Construction Building Materials1997，11，2： | 1 |
| 10 | Effect of combined occupational exposure to noise and organic solvents on hearing显示文摘 | METWALLY F M HISHAM M A HEBA M A | 2012 | Toxicol Ind Health2012，28，10： | 1 |
| 11 | Vesicoureteral reflux in patients with double pigtail stents显示文摘 | Hisham A Hasan M Mohammed F | 1991 | Am J Urology1991，146，4： | 1 |
| 12 | Structural parameters of collagen nerve grafts influence peripheral nerve regeneration显示文摘 | FELIX S HISHAM F GERALD W | 2005 | Biomaterials2005，26，16： | 1 |
| 13 | Vesicoureteral reflux in patients with double pigtail stents显示文摘 | Hisham A Hasan M Mohammed F | 1991 | Am J Urol1991，146，： | 1 |
| 14 | Two-stepcontrollable electrochemical etching of tungsten scanningprobe microscopy tips 显示文摘 | Yasser K Hisham A F Zhang Y P | 2012 | Review of Scientific Instru-ments2012，83，6： | 1 |
| 15 | Simulation of stability and dynamics of multistage flash desalination显示文摘 | Hala A F Andrea C Hisham E ct al | 2011 | Desalination2011，281，： | 1 |
| 16 | Central nervous system tumors and three-dimensional cell biology: Current and future perspectives in modeling显示文摘Central nervous system(CNS)tumors are a variety of distinct neoplasms that present multiple challenges in terms of treatment and prognosis.Glioblastoma,the most common primary tumor in adults,is associated with poor survival and remains one of the least treatable neoplasms.These tumors are highly heterogenous and complex in their nature.Due to this complexity,traditional cell culturing techniques and methods do not provide an ideal recapitulating model for the study of these tumors’behavior in vivo.Two-dimensional models lack the spatial arrangement,the heterogeneity in cell types,and the microenvironment that play a large role in tumor cell behavior and response to treatment.Recently,scientists have turned towards three-dimensional culturing methods,namely spheroids and organoids,as they have been shown to recapitulate tumors in a more faithful manner to their in vivo counterparts.Moreover,tumor-on-a-chip systems have lately been employed in CNS tumor modeling and have shown great potential in both studying the pathophysiology and therapeutic testing.In this review,we will discuss the current available literature on in vitro threedimensional culturing models in CNS tumors,in addition to presenting their advantages and current limitations.We will also elaborate on the future implications of these models and their benefit in the clinical setting. | Zaki Abou-Mrad Jolie Bou Gharios Maya M Moubarak Ahmad Chalhoub Charbel Moussalem Hisham F Bahmad Wassim Abou-Kheir | 2021 | World Journal of Stem Cells2021，13，8： | 0 |
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