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| 1 | Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis显示文摘AIM: Pancreatic regenerating protein (regⅠ) stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal andβ-cells. This suggests that regⅠand its receptor may play a role in recovery after pancreatic injury. We hypothesized that regⅠand its receptor are induced in acute pancreatitis. METHODS: Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls (4 rats/group). RegⅠreceptor mRNA, serum regⅠprotein, and tissue regⅠprotein levels were determined by Northern analysis, enzyme-linked immunosorbent assay (ELISA), and Western analysis, respectively. Immunohistochemistry was used to localize changes in regⅠand its receptor. RESULTS: Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum regⅠconcentrations from controls. However, Western blot demonstrated increased tissue levels of regⅠat 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in regⅠreceptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells. CONCLUSION: Acute pancreatitis results in increased tissue regⅠprotein levels localized to the acinar and ductal cells, and a parallel threefold induction of regⅠreceptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg I and its receptor may be important for recovery from acute pancreatitis. | Martin H Bluth Sameer A Patel Brian K Dieckgraefe Hiroshi Okamoto Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，28： | 19 |
| 2 | Genetic and phenological variation of tocochromanol(vitamin E)content in wild(Daucus carota L.var.carota)and domesticated carrot(D.carota L.var.sativa)显示文摘Carrot roots(Daucus carota L.var.sativa)produce tocochromanol compounds,collectively known as vitamin E.However,little is known about their types and amounts.Here we determined the range and variation in types and amounts of tocochromanols in a variety of cultivated carrot accessions throughout carrot postharvest storage and reproductive stages and in wild-type roots(Daucus carota L.var.carota).Of eight possible tocochromanol compounds,we detected and quantified α-,and the combined peak for β-and γ-forms of tocopherols and tocotrienols.Significant variation in amounts of tocochromanol compounds was observed across accessions and over time.Large increases in a-tocopherol were noted during both reproductive growth and the postharvest stages.The variation of tocochromanols in carrot root tissue provides useful information for future research seeking to understand the role of these compounds in carrot root tissue or to breed varieties with increased levels of these compounds. | Claire H Luby Hiroshi A Maeda Irwin L Goldman | 2014 | Horticulture Research2014，1，1： | 6 |
| 3 | Priming with GGSF effectively enhances low-dose Ara-G-induced in vivo apoptosis in myeloid leukemiacells 显示文摘 | Hiroshi K Mitsuo H | 1999 | Exp Hematol1999，27，： | 1 |
| 4 | Antitumour triterpenes of Maytenus diversifolia 显示文摘 | Hiroshi N Hideyo S Teruhisa H | 1986 | Phytochemistry1986，25，2： | 1 |
| 5 | Transgen-ic perennial ryegrass plants expressing wheat fructosyltransferasegenes accumulate increased amounts of fructan and acquire in-creased tolerance on a cellular level to freezing 显示文摘 | HIROSHI H KANAZAWA A KAWAKAMI A | 2004 | Plant Sci-ence2004，167，4： | 1 |
| 6 | P-type Electrical Conduction in Transparent Thin Films of CuAlO2 显示文摘 | Hiroshi K Masahiro Y Hiroyuki H | 1997 | Nature1997，359，30： | 1 |
| 7 | Comparison of lasing performance of Tm,Ho:YLF laser by use of single and double cavities显示文摘 | JUN I HAYATO N HIROSHI H | 2000 | Appl Opt2000，39，15： | 1 |
| 8 | Synthesis of dideoxypurinenucleosides vie the palladium catalyzed reduction of 9-(2,5 di-o-acetyl 3 bromo-3-deoxy-β-D-xylofurano syl) purine derivatives显示文摘 | Hiroshi S Yusuke A Yutaka H | 1996 | Nucleosides & Nucleotides1996，15，13： | 1 |
| 9 | Hypotensive principle of Astragalus and Hedysarum roots显示文摘 | Hiroshi H Funayama S Endo K | 1976 | Planta Med1976，30，4： | 1 |
| 10 | Properties of the Na+/K+ pump in small neurons from adult rat dorsal root ganglia显示文摘 | Kanako H Hiroshi M Mitsuru S | 2003 | Br J Pharmacol2003，138，8： | 1 |
| 11 | Biochemical characterization and expression of recombinant ACC oxidase in Escherichia coli and endogenous ACC oxidase from kiwifruit显示文摘 | ZHONG C X HIROSHI H YOSHINORI I | 1998 | Postharvest Biology and Technology1998，14，： | 1 |
| 12 | Inhibitory effects of Chrysanthemum species extracts on formation of advancedg|ycation end products显示文摘 | Kentaro T N Hiroshi S Miyuki H | 2009 | Food Chemistry2009，116，5： | 1 |
| 13 | Hemodynamic compromiseas a cause of Internal border-zone infarction and cortical neuronaldamage in,atherosclerotic middle cerebral artery disease 显示文摘 | Hiroshi Y Ryuichi N Tatsuya H | 2009 | Stroke2009，40，： | 1 |
| 14 | Thl/ Th2 cells in patients with multiple myeloma 显示文摘 | Murakami H Ogawara H Hiroshi H | 2004 | Hematology2004，9，1： | 1 |
| 15 | Application of the interseptal alveolotomy for closing the oroantral fistula 显示文摘 | Minoru H Hiroshi T Mistuhiko M | 1995 | Oral MaxillofacSurg1995，53，1： | 1 |
| 16 | Structures of Forsythoside C and D, antibacterial principles of Forsythia suspensa fruits显示文摘 | Katsuya E Hiroshi H | 1982 | Heterocycles1982，19，11： | 1 |
| 17 | Implication of cardiac remodeling in heart falure: mochanismsand therapeutic strategies显示文摘 | Hiroyuki T Hiroshi H Toshio N | 2003 | Internal Medicine2003，42，： | 1 |
| 18 | De/,elopment of biological filter as tertiary treatment for effective nitrogen removal: biological filter for tertiary treatment 显示文摘 | JINWO0 J TAIRA H HIROSHI T | 2006 | Water Research2006，40，6： | 1 |
| 19 | Cardiopulmonary bypass produces greatpulmonary them systemic proinflammatory cytokines显示文摘 | Hiroshi H Daniel IS is | 2000 | Anesth Analg2000，90，： | 1 |
| 20 | Kinematics and dynamics of a 6 degree-of-freedom fully parallel manipulator with elastic joints显示文摘 | WANG Shaochi HIROMITSU H HIROSHI K | 2003 | Mechanism and MachineTheory2003，38，5： | 1 |
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