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| 1 | Approach to early-onset colorectal cancer:Clinicopathological,familial,molecular and immunohistochemical characteristics显示文摘AIM:To characterize clinicopathological and familial features of early-onset colorectal cancer(CRC) and compare features of tumors with and without microsatellite instability(MSI).METHODS:Forty-five patients with CRC aged 45 or younger were included in the study.Clinical information,a three-generation family history,and tumor samples were obtained.MSI status was analyzed and mismatch repair genes were examined in the MSI families.Tumors were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected antibodies.RESULTS:Early onset CRC is characterized by advanced stage at diagnosis,right colon location,low-grade of differentiation,mucin production,and presence of polyps.Hereditary forms represent at least 21% of cases.Eighty-one percent of patients who died during followup showed a lack of expression of cyclin E,which could be a marker of poor prognosis.β-catenin expression was normal in a high percentage of tumors.CONCLUSION:Early-onset CRC has an important familial component,with a high proportion of tumors showing microsatellite stable.Cyclin E might be a poor prognosis factor. | Jose Perea Edurne Alvaro Yolanda Rodríguez Cristina Gravalos Eva Sánchez-Tomé Barbara Rivera Francisco Colina Pablo Carbonell Rogelio González-Sarmiento Manuel Hidalgo Miguel Urioste | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 2 | Prediction of blood volu- me in normal human adults 显示文摘 | Nadler S B Hidalgo J U Bloch T | 1962 | Surgery1962，51，2： | 1 |
| 3 | Accuracy of High-Resolusion CT in Distinguishing between Pneumocystis Carinii Pneumonia and Non-Pneumocystis Carinii Pneumonia in AIDS Patients显示文摘 | Hidalgo A Falco V Mauleon S | 2003 | Eur Radiol2003，13，5： | 1 |
| 4 | Accuracy of High-Resolution CT i n Distinguishing between Pneumocystis Carinii Pneumonia and Non-Pneumocystis Carinii Pneumonia in AIDS Patients 显示文摘 | Hidalgo A Falco V Mauleon S | 2003 | Eur Radiol2003，13，5： | 1 |
| 5 | In?uence of ge- netic and environmental factors on selected nutritional traits of Triticum monococcum显示文摘 | Hidalgo A Brandolini A Ratti S | 2009 | Journal of Agricultural and Food Chemistry2009，，57： | 1 |
| 6 | Prediction of blood volume in normal human adults 显示文摘 | Nadler S B Hidalgo J U Bloch T | 1962 | Surgery1962，51，2： | 1 |
| 7 | Development of matrix metalloproteinase inhibitors in cancer therapy显示文摘 | Eckhardt S G | 2001 | J Natl Cancer Inst2001，93，3： | 1 |
| 8 | Removal of lead (Ⅱ) and cadmium(Ⅱ) from aqueous solutions using grape stalk waste显示文摘 | Martinez M Miralles N Hidalgo S | | 0，，1： | 1 |
| 9 | Lateral punch-through TVS devices for on- chip protection in low-voltage applications显示文摘 | URRESTI J HIDALGO S FLORES D ROIG J CORTE' s I REBOLL J | 2005 | Microelec- tronics Reliability2005，45，6： | 1 |
| 10 | Hybrid 'Sinta' papaya exhibits unique ACC synthase 1 eDNA isoforms显示文摘 | Hidalgo M S Tecson-Mendoza E M Laurena A C | 2005 | J Bioehem Mol Biol2005，38，3： | 1 |
| 11 | Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)显示文摘 | Bentley SD Chater KF Cerdeno-Tarraga AM Challis GL Thomson NR James KD Harris DE Quail MA Kieser H Harper D Bateman A Brown S Chandra G Chen CW Collins M Cronin A Fraser A Goble A Hidalgo J Hornsby T Howarth S Huang CH Kieser T Larke L Murphy L Oliver K O | | 0，，： | 1 |
| 12 | Surgical management of diplopia in dysthyroid orbitopathy 显示文摘 | Bok C Hidalgo C Morax S | 2007 | J Fr Ophtamol2007，30，4： | 1 |
| 13 | PREDICTION OF BLOOD VOLUME IN NORMAL HUMAN ADULTS 显示文摘 | NADLER S B HIDALGO J U BLOCH T | 1962 | Surgery1962，51，2： | 1 |
| 14 | Responses to T cell receptor/ CD3 and interleukin-2 receptor stimulation are altered in T cells from B cell non-Hodgkin's lymphomas显示文摘 | Kudoh S Wang O Hidalgo OF | 1995 | Cancer Immunol Immu- nother1995，41，3： | 1 |
| 15 | Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow显示文摘 | Yoshio Katayama Michela Battista Wei-Ming Kao Andrés Hidalgo Anna J. Peired Steven A. Thomas Paul S. Frenette | 2006 | Cell2006，，2： | 1 |
| 16 | Development of matrix metalloproteinase inhibitors in cancer therapy显示文摘 | HIDALGO M ECKHARDT S G | 2001 | J Natl Cancer Inst2001，93，3： | 1 |
| 17 | Addressing the challenges of pancreatic cancer: Future directions for improv- ing outcomes显示文摘 | HIDALGO M CASCINU S KLEEFF J | 2015 | Pancreatology2015，15，1： | 1 |
| 18 | Prog- nostic factors in carcinoma of the penis: multivariate analysis of 145 patients treated with amputation and lymphadenectomy显示文摘 | Lopes A Hidalgo G S Kowalski L P | 1996 | J Urol1996，156，5： | 1 |
| 19 | Prognostic factors in Carcinoma of the penis: multivariate analysis of 145 patients treated with amputation and lymphadenectomy显示文摘 | Lopes A Hidalgo G S Kowalski L P | 1996 | J Urol1996，156，： | 1 |
| 20 | A randomized,phaseII trial of two dose levels of temsirolimus(CCI-779)in patientswith extensive-stage small-cell lung cancer who have respon-ding or stable disease after induction chemotherapy:A trial ofthe eastern cooperative oncology group(e1500)显示文摘 | Pandya KJ Dahlberg S Hidalgo M | 2007 | J ThoracOncol2007，2，11： | 1 |
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