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| 1 | Soluble ST2:A new and promising activity marker in ulcerative colitis显示文摘AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r = 0.76 and r = 0.67,P < 0.0001,respectively),and with the pro-inflammatory cytokine,tumor necrosis factor-α(r = 0.69 and r = 0.61,respectively,P < 0.0001).Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild(r = 0.44,P = 0.004),moderate(r = 0.59,P = 0.002) and severe disease(r = 0.82,P = 0.002).Only patients with inactive UC showed no significant correlation(r = 0.45,P = 0.267).CONCLUSION:sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker. | David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 2 | Glucocorticosteroid therapy in inflammatory bowel diseases: From clinical practice to molecular biology显示文摘Inflammatory bowel diseases(IBDs),such as ulcerative colitis and Crohn's disease,are chronic pathologies associated with a deregulated immune response in the intestinal mucosa,and they are triggered by environmental factors in genetically susceptible individuals.Exogenous glucocorticoids(GCs)are widely used as anti-inflammatory therapy in IBDs.In the past,patients with moderate or severe states of inflammation received GCs as a first line therapy with an important effectiveness in terms of reduction of the disease activity and the induction of remission.However,this treatment often results in detrimental side effects.This downside drove the development of second generation GCs and more precise(non-systemic)drugdelivery methods.Recent clinical trials show that most of these new treatments have similar effectiveness to first generation GCs with fewer adverse effects.The remaining challenge in successful treatment of IBDs concerns the refractoriness and dependency that some patients encounter during GCs treatment.A deeper understanding of the molecular mechanisms underlying GC response is key to personalizing drug choice for IBDs patients to optimize their response to treatment.In this review,we examine the clinical characteristics of treatment with GCs,followed by an in depth analysis of the proposed molecular mechanisms involved in its resistance and dependence associated with IBDs.This thorough analysis of current clinical and biomedical literature may help guide physicians in determining a course of treatment for IBDs patients and identifies important areas needing further study. | Karen Dubois-Camacho Payton A Ottum Daniel Franco-Munoz Marjorie De la Fuente Alejandro Torres-Riquelme David Díaz-Jiménez Mauricio Olivares-Morales Gonzalo Astudillo Rodrigo Quera Marcela A Hermoso | 2017 | World Journal of Gastroenterology2017，23，36： | 6 |
| 3 | Taking aim on bacterial pathogens: from phage therapy to enzybioties 显示文摘 | Hermoso J A Garm'a J L Garm'a P | 2007 | Curr Opin Microbiol2007，10，： | 1 |
| 4 | Lipid nanosystems enhance the bioavailability and the therapeutic efficacy of FTY720 in acute myeloid leukemia 显示文摘 | EstellaHermoso de Mendoza A CastelloCros R Imbuluzqueta E | 2015 | J Biomed Nanotechnol2015，11，4： | 1 |
| 5 | Antileishmanial Activities of Dihydrochalcones from Piper elongatum and Synthetic Related Compounds,Structural Requirements for Activity显示文摘 | HERMOSO A JIMENEZ I A MAMANI Z A | 2003 | Bioorganic & Medicinal Chemistry2003，，11： | 1 |
| 6 | Molecular diagnosis of Saksenaea vasiformis cutaneous infection after scorpion sting in an immunocompetent adolescent显示文摘 | Lechevalier P Hermoso DG Carol A | 2008 | J Clin Microbiol2008，46，9： | 1 |
| 7 | Structural basis for selective recognition of pneumococcal cell wall by modular cndolysin from phage Cp-I显示文摘 | Hermoso JA Monterroso B Albert A | 2003 | Structure2003，11，： | 1 |
| 8 | Use of enzyme-linked immunosorbent assay (ELISA) for detection of Citrus tristeza virus (CTV) in differ- ent aphid species显示文摘 | Cambra M Hermoso de Mendoza A Moreno P | 1982 | Proc Int Soc Citriculture1982，1，： | 1 |
| 9 | Effects of exercise on functional aerobic capacity in lower limb osteoarthritis: a systematie re- view 显示文摘 | Escalante Y Gareia - Hermoso A Saavedra JM | 2011 | J Sci Med Sport2011，14，3： | 1 |
| 10 | Coeliac axis ligation in a unmangageable upper gastrointestinal haemorrhage显示文摘 | Lopez-Tomassetti Fernandez EM Herrero Segura A Gonzalez Hermoso F | 2005 | Scand J Gastroenterol2005，40，4： | 1 |
| 11 | ArchDB:Automated Protein Loop Classification as a Tool for Structural Genomics显示文摘 | Espadaler J Fernandez-Fuentes N Hermoso A | 2004 | Nucleic Acids Research2004，32，： | 1 |
| 12 | Taking aim on bacterial pathogens : from phage therapy to enzybiotics显示文摘 | Hermoso J A Garcia J L Garcia P | 2007 | Curt Opin Microbiol2007，10，5： | 1 |
| 13 | 显示文摘 | Sanz-Aparicio J Hermoso J A Martinez-Ripoll M | 1998 | J Mol Biol1998，，275： | 1 |
| 14 | Antileish-manial Activities of Dihydrochalcones from Piper elongatum and Synthetic Related Compounds,Structural Requirements for Activity 显示文摘 | Hermoso A Jimenez I A Mamani Z A | 2003 | Bioorganic Medicinal Chemistry Letters2003，11，： | 1 |
| 15 | Evolution and complications of chest trauma显示文摘 | Avila Martinez R J Herndndez Voth A Marr6n Ferndndez C Hermoso Alarza F Martinez Serna I Mariscal de Alba A | 2013 | Arch Bronconeumol2013，49，： | 1 |
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