|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | CD34^+ peripheral blood progenitor cell and monocyte derived dendritic cells:a comparative analysis显示文摘 | HERBST B KOHLER G MACHENSEN A | 1997 | Br J Haematol1997，99，3： | 1 |
| 3 | Work- flow mining A survey of issues and approaehes显示文摘 | van der Aalst W M P van Dongen B F Herbst J | 2003 | Data and Know ledge Engineering2003，47，2： | 1 |
| 4 | Eclampsia in Scandinavia:Incidence,substandard care,and potentially preventable cases显示文摘 | Andersgaard A B Herbst A Johansen M | 2006 | Acta Obstet Gynecol Scand2006，85，8： | 1 |
| 5 | On the extension of the Painleve property to difference equations显示文摘 | ABLOWITZ M J HALBURD R HERBST B | 2000 | Nonlin- earity2000，13，3： | 1 |
| 6 | Dynamics of air combat显示文摘 | HERBST W B | 1982 | Aircraft1982，20，7： | 1 |
| 7 | Schrtidinger operator with magnetic fields 显示文摘 | AVRON J HERBST I SIMON B | 1978 | Duke Math J1978，45，4： | 1 |
| 8 | Pressure broadening of the oxygen A-band measured by laser spectroscopy显示文摘 | SCHERER B HERBST J | 2009 | Proceedings of SPIE2009，7222，72： | 1 |
| 9 | Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non small cell lung cancer treated with chemo- therapy alone and in combination with erlotinib 显示文摘 | Eberhard D A Johnson B E Amler L C Goddard A D Heldens S L Herbst R S | 2005 | J Clin On- col2005，23，： | 1 |
| 10 | Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyorsinekinase, in symptomatic patients with non-small cell lung cancer: randomized tfial 显示文摘 | Kris M G Natale R B Herbst R S | 2003 | JAMA2003，290，16： | 1 |
| 11 | Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial显示文摘 | Kris M G Natale R B Herbst R S | 2003 | JAMA2003，290，16： | 1 |
| 12 | Future Fighter Technologies显示文摘 | Herbst W B | 1980 | Journal of Aircraft1980，17，8： | 1 |
| 13 | Efficacy of gefitinib, aninhibitor of the epidermal growth factor receptor tyrosine kinase, insymptomatic patients with non-small cell lung cancer: a randomized trial显示文摘 | Kris M G Natale R B Herbst R S | 2003 | JAMA2003，290，16： | 1 |
| 14 | ESPEN guidelines on enteral nutrition-summary显示文摘 | Schutz T Valentini L Herbst B | 2006 | Z Gastroenterol2006，44，8： | 1 |
| 15 | Stress driven phase transformation in ZrO2 film 显示文摘 | Benali B Herbst Ghysel M Gallet I | 2006 | Applied Surface Science2006，253，： | 1 |
| 16 | Interferon gamma acli vated macrophages kill mycobacteria by nitric oxide induced apoptosis显示文摘 | Herbst S Schaible U E Schneider B E | 2011 | PLoS One2011，6，19： | 1 |
| 17 | Future fighter technologies显示文摘 | Herbst W B | 1980 | Journal of Aircraft1980，17，8： | 1 |
| 18 | Modelling the spatial variability of soil moisture in a micro-scale catchment and comparison with field data using geostatistics显示文摘 | Herbst M Diekkruger B | 2003 | Physics and Chemistry of the Earth2003，28，： | 1 |
| 19 | Gradients of salinity stress, environmental stability and water chemistry as a template for defining habitat types and physiological strategies in inland salt waters显示文摘 | Herbst D B | 2001 | Hydrobiologia2001，，466： | 1 |
| 20 | Work-flow minings a survey of issues and approaches 显示文摘 | Van Der A W M P Van Dongen B F Herbst J | 2003 | Data andKnowledge Engineering2003，16，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员