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| 1 | Neuroimaging the brain-gut axis in patients with irritable bowel syndrome显示文摘AIM:To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome(IBS).METHODS:A database search for relevant literature was conducted using Pub Med,Scopus and Embase in February 2015.Date filters were applied from the year2009 and onward,and studies were limited to those written in the English language and those performed upon human subjects.The initial search yielded 797articles,out of which 38 were pulled for full text review and 27 were included for study analysis.Investigations were reviewed to determine study design,methodology and results,and data points were placed in tabular format to facilitate analysis of study findings across disparate investigations.RESULTS:Analysis of study data resulted in the abstraction of four key themes:Neurohormonal differences,anatomic measurements of brain structure and connectivity,differences in functional responsiveness of the brain during rectal distention,and confounding/correlating patient factors.Studies in this review noted alterations of glutamate in the left hippocampus(HIPP),commonalities across IBS subjects in terms of brain oscillation patterns,cortical thickness/gray matter volume differences,and neuroanatomical regions withincreased activation in patients with IBS:Anterio cingulate cortex,mid cingulate cortex,amygdala anterior insula,posterior insula and prefrontal cortex.A striking finding among interventions was the substantia influence that patient variables(e.g.,sex,psychologica and disease related factors)had upon the identification of neuroanatomical differences in structure and con nectivity.CONCLUSION:The field of neuroimaging can provide insight into underlying physiological differences that distinguish patients with IBS from a healthy population. | Kristen R Weaver Lee Anne B Sherwin Brian Walitt Gail D'Eramo Melkus Wendy A Henderson | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，2： | 8 |
| 2 | Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis显示文摘AIM: To investigate the vasoactive intestinal peptides(VIP) expression in irritable bowel syndrome(IBS) and trinitrobenzene sulfonic acid(TNBS) induced colitis.METHODS: The VIP gene expression and protein plasma levels were measured in adult participants(45.8% male) who met Rome Ⅲ criteria for IBS for longer than 6 mo and in a rat model of colitis as induced by TNBS.Plasma and colons were collected from naive and inflamed rats.Markers assessing inflammation(i.e.,weight changes and myeloperoxidase levels) were assessed on days 2,7,14 and 28 and compared to controls.Visceral hypersensitivity of the rats was assessed with colo-rectal distension and mechanical threshold testing on hind paws.IBS patients(n = 12) were age,gender,race,and BMI-matched with healthy controls(n = 12).Peripheral whole blood and plasma from fasting participants was collected and VIP plasma levels were assayed using a VIP peptide-enzyme immunoassay.Human gene expression of VIP was analyzed using a custom PCR array.RESULTS: TNBS induced colitis in the rats was confirmed with weight loss(13.7 ± 3.2 g) and increased myeloperoxidase activity.Visceral hypersensitivity tocolo-rectal distension was increased in TNBS treated rats up to 21 d and resolved by day 28.Somatic hypersensitivity was also increased up to 14 d post TNBS induction of colitis.The expression of an inflammatory marker myeloperoxidase was significantly elevated in the intracellular granules of neutrophils in rat models following TNBS treatment compared to naive rats.This confirmed the induction of inflammation in rats following TNBS treatment.VIP plasma concentration was significantly increased in rats following TNBS treatment as compared to naive animals(P < 0.05).Likewise,the VIP gene expression from peripheral whole blood was significantly upregulated by 2.91-fold in IBS patients when compared to controls(P < 0.00001; 95%CI).VIP plasma protein was not significantly different when compared with controls(P = 0.193).CONCLUSION: Alterations in VIP expression may play a role in IBS.Therefore,a better understanding of the physiology of VIP could lead to new therapeutics. | Arseima Y Del Valle-Pinero LeeAnne B Sherwin Ethan M Anderson Robert M Caudle Wendy A Henderson | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 3 | Pharmacokinetics of paraeetamol (acetaminophen) after intravenous and oral administration显示文摘 | Rawlins M D Henderson D B Hiiab A R | 1977 | Eur J Clin Pharmacol1977，11，4： | 1 |
| 4 | Geographic Localization of Knowledge Spillovers as Evidenced by Patent Citations 显示文摘 | Jaffe A B Trajtenberg M Henderson R | 1993 | Quarterly Journal of Economics1993，，108： | 1 |
| 5 | Baculoviral expression and characterization of rodent cathepsin S显示文摘 | Mason C S Lamers M B Henderson I M | 2001 | Protein Expression and Purication2001，23，： | 1 |
| 6 | Geographic locatization of knowledge spillovers as evidencedby patent citations显示文摘 | Jaffe A B Trajtenberg M Henderson R | 1993 | Quarterly Journal of Economics1993，，108： | 1 |
| 7 | Spatial and temporal patterns in the seed bank and vegetation of a desert grassland community显示文摘 | HENDERSON C B PETERSEN K E REDAK R A | 1988 | Journal of Ecology1988，76，： | 1 |
| 8 | Architectural innovation: The reconfiguration of existing product technologies and the failure of established firms 显示文摘 | Henderson R M Clark K B | 1990 | Administratiw~ Science Quarterly1990，35，1： | 1 |
| 9 | Architectural innovation:the reconfiguration of existing product technologies and the failure of established firms显示文摘 | Henderson R Clark K B | 1990 | Administrative Science Quarterly1990，35，： | 1 |
| 10 | Distribution and petrogenetic behavior of trace elements in granitic pegmatite quartz from South Norway显示文摘 | Larsen R B Henderson I Ihlen P M | 2004 | Contributions to Mineralogy and Petrology2004，147，5： | 1 |
| 11 | Architectural innova- tion: The reconfiguration of existing product technologies and the failure of established firms 显示文摘 | HENDERSON R M CLARK K B | 1990 | Administrative Science Quarterly1990，35，1： | 1 |
| 12 | Fish assemblages associated with artificial reefs of concrete aggregates or quarry stone offshore Miami Beach, Florida, USA 显示文摘 | WALKER B K HENDERSON B | 2002 | Aquat Living Resulr2002，15，： | 1 |
| 13 | Trends in research in two general psychiatric joumals in 1969 ~ 1990 : Research on research 显示文摘 | Pincus HA Henderson B Blackwood D | 1993 | Am J Psychiatry1993，150，1： | 1 |
| 14 | Architectural innovation: the reconfiguration of existing product technologies and the failure of established firms 显示文摘 | Henderson R M Clark K B | 1990 | Administrative Science Quarterly1990，35，1： | 1 |
| 15 | Corporate venture capital: effecting resource combinations and transfers显示文摘 | Henderson J Leleux B | 2002 | Babson Entrepreneurial Review2002，，： | 1 |
| 16 | Review:Photodynamic therapy显示文摘 | DOUGHERTY J J GOMER C J HENDERSON B W | 1998 | J Natl Cancer Inst1998，90，12： | 1 |
| 17 | Architectural innovation:the reconfiguration of exiting product technologies and the failure of established firms显示文摘 | Henderson RM Clark K B | 1990 | Administrative Science Quarterly1990，35，： | 1 |
| 18 | Patent citations and geography of knowl- edge spillovers : A reassessment 显示文摘 | Henderson R Jaffe A B | 2005 | American Economic in Re- view2005，1，3： | 1 |
| 19 | Architectural in- novation: the recon figuration of existing product tech-nologies and the failure of established firms 显示文摘 | Revecca M Henderson Kim B Clark | 1990 | Ad- ministrative Science Quarterly1990，35，1： | 1 |
| 20 | Geographic localization of knowledge spiUovers as evidenced by patent citations显示文摘 | Jaffe A B Trajtenberg M Henderson R | 1993 | Quarterly Journal of Economics1993，108，3： | 1 |
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