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| 1 | Probiotic intervention has strain-specific anti-inflammatory effects in healthy adults显示文摘AIM: To evaluate the effects of three potentially anti- inflammatory probiotic bacteria from three different genera on immune variables in healthy adults in a clinical setting based on previous in vitro characterization of cytokine responses. METHODS: A total of 62 volunteers participated in this randomized, double-blind and placebo-controlled parallel group intervention study. The volunteers were randomized to receive a milk-based drink containing either Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis ssp. lactis Bb12 (Bb12), or Propionibacterium freudenreichii ssp. shermanii JS (PJS) or a placebo drink for 3 wk. Venous blood and saliva samples were taken at baseline and on d 1, 7 and 21. Fecal samples were collected at baseline and at the end of intervention. RESULTS: The serum hsCRP expressed as the median AUC0-21 (minus baseline) was 0.018 mg/L in the placebo group, -0.240 mg/L in the LGG group, 0.090 mg/L in the Bb12 group and -0.085 mg/L in the PJS group (P = 0.014). In vitro production of TNF-α from in vitro cultured peripheral blood mononuclear cells (PBMC) was significantly lower in subjects receiving LGG vs placebo. IL-2 production from PBMC in the Bb12 group was significantly lower compared with the other groups. CONCLUSION: In conclusion, probiotic bacteria have strain-specific anti-inflammatory effects in healthy adults. | Riina A Kekkonen Netta Lummela Heli Karjalainen Sinikka Latvala Soile Tynkkynen Salme Jrvenp Hannu Kautiainen Ilkka Julkunen Heikki Vapaatalo Riitta Korpela | 2008 | World Journal of Gastroenterology2008，14，13： | 6 |
| 2 | Sydney Multicenter Study f Parkinson'S disease: non-L-dopa-responsive problems do- rainate at 15 years显示文摘 | Hely M A Morris J G Reid W G | 2005 | Mov Disord2005，20，2： | 1 |
| 3 | The Sydney multicenter study of Parkinson's disease:the inevitability of dementia at 20 years显示文摘 | HELY M A REID W G ADENA MICHAELl A | 2008 | Movement Disorders:Official Journal of the Movement Disorder Society2008，23，6： | 1 |
| 4 | Electrochemical oxidation and determination of ceftriaxone on a glassy carbon and carbon-nanotubemodified glassy carbon electrodes显示文摘 | Majdi S Jabbari A Heli H | 2009 | Journal of Solid State Electrochemistry2009，13，3： | 1 |
| 5 | Dielectric properties of BST/polymer composite显示文摘 | Tao Hu a Jari Juuti Heli Jantunen | 2007 | Journal of the European Ceramic Society2007，27，： | 1 |
| 6 | Stainless steel as bipolar plate material for polymer electrolyte membrane fuel cells 显示文摘 | WANG Heli SWEIKART M A TURNER J A | 2003 | Power Sources2003，，115： | 1 |
| 7 | Austenitic stainless steels in high temperature phosphoric acid显示文摘 | Wang Heli Turner J A | 2008 | Journal of Power Sources2008，180，2： | 1 |
| 8 | An aqueous rechargeable lithium-ion battery based on LrCof), nanoparticles cathode and LiV, O, nanosheets anode显示文摘 | Yadegari H Jabbari A Heli H | 2012 | Journal of Solid State Electrochemistry2012，16，1： | 1 |
| 9 | Coffee consumptionand risk of type 2 diabetes mellitus显示文摘 | Reunanen A Helivaara M Aho K | 2003 | Lancet2003，361，9358： | 1 |
| 10 | Low-temperature synthesis of LiV3 O, nanosheets as an anode material with high power density for aqueous lithium-ion batteries显示文摘 | Heli H Yadegari H Jabbari A | 2011 | Materials Chemistry and Physics2011，126，3： | 1 |
| 11 | Ion-pair high performance liquid chromatographic study of the hydrolysis behaviour of reactive fluomtriazinic dyes显示文摘 | ZOTOU A EI Frherjadis I HELI M | 2002 | Dyes and Pigments2002，53，3： | 1 |
| 12 | Skeletal stability of Le Fort Ⅰ osteotomy in patients with isolated cleft palate and bilateral cleft lip and palate显示文摘 | Heli(o)vaara A Ranta R Hukki J | 2002 | Int J Oral Maxillofac Surg2002，31，4： | 1 |
| 13 | Stainless steel as bipolar plate material for polymer electrolyte membrane fuel cells显示文摘 | WANG Heli SWEIKART Mary Ann TURNER John A | 2003 | J Power Sources2003，115，： | 1 |
| 14 | Transforming learning and knowledge ereation on the shop Floor显示文摘 | Virkunen J Heli A | 2004 | Human Resoures Development and Management2004，4，1： | 1 |
| 15 | Adsorption of human serum albumin onto glassy carbon surface-applied to albumin-modified electrode: mode of protein-ligand interactions显示文摘 | HELI H SATTARAHMADY N MOOSAVI-MOVAHEDI A A | 2007 | J Electroanal Chem2007，610，1： | 1 |
| 16 | Ion-pair high performance liquid chromatographic study of the hydrolysis behaviour of reactive fluorotriazinie dyes 显示文摘 | Zotou A Eleftheriadis I Heli M | 2002 | Dyes Pigm2002，53，4： | 1 |
| 17 | Vitamin D status and the risk of lung cancer:a cohort study in Finland显示文摘 | KILKKINEN A KNEKT P HELI VAARA M | 2008 | Cancer Epidemiol Biomarkers Prev2008，17，11： | 1 |
| 18 | Quantification and characterizadon of microbial populations associated with spoiled, vacuumpacked Vienna sausages显示文摘 | HELY A CLOETE T E HOLZAPFEL W H | 1991 | Food Microbiology1991，8，2： | 1 |
| 19 | A study of the elec- trocatalytic oxidation of aspirin on a nickel hydroxide- modified nickel electrode 显示文摘 | MAJDI S JABBARI A HELI H | 2007 | J Solid State Electr2007，11，5： | 1 |
| 20 | Turner, stainless steel as bipolar plate material for polymer electrolyte membrane fuel cell 显示文摘 | Wang Heli Mary Ann Swei Kart John A | 2003 | Journal of Sources2003，115，： | 1 |
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