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| 1 | Reovirus,isolated from SARS patients显示文摘Beijing has been severely affected by SARS, and SARS-associated coronavirus has been confirmed as its cause. However, clinical and experimental evidence implicates the possibility of co-infection. In this report, reovirus was isolated from throat swabs of SARS patients, including the first case in Beijing and her mother. Identification with the electron microscopy revealed the characteristic features of reovirus. 24 of 38 samples from other SARS cases were found to have serologic responses to the reovirus. Primers designed for reovirus have amplified several fragments of DNA, one of which was sequenced (S2 gene fragment), which indicates it as a unique reovirus (orthoreovirus). Preliminary animal experiment showed that inoculation of the reovirus in mice caused death with atypical pneumonia. Nevertheless, the association of reovirus with SARS outbreak requires to be further investigated. | DUANQing ZHUHong YANGYi LIWeihua ZHOUYusen HEJun HEKun ZHANGHaojie ZHOUTao SONGLihua GANYonghua TANHua JINBaofeng LIHuiyan ZUOTingting CHENDehui ZHANGXuemin | 2003 | Chinese Science Bulletin2003，48，13： | 16 |
| 2 | TCP1 regulates Wnt7b/β-catenin pathway through P53 to influence the proliferation and migration of hepatocellular carcinoma cells显示文摘Dear Editor,Molecular chaperones are critical mediators of oncogenesis and necessary for cell survival.1 The cytoplasmic chaperone TRiC(Tcomplex protein-1 ring complex,also known as CCT)comprises two back-to-back stacked rings,with each ring containing eight subunits(CCT1–CCT8).2 And the effects of CCT subunits on tumors may be different.However,the roles of the CCT1 subunit(also known as TCP1)in hepatocellular carcinoma(HCC)and its molecular mechanism have not been investigated thoroughly.Understanding these details can provide new ideas and strategies for treating HCC. | Nanhong Tang Xiaoling Cai Lirong Peng Hekun Liu Yuanzhong Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 3 | The effect of porosity on the mechanical properties of 3D-printed triplyperiodic minimal surface (TPMS) bioscaffold显示文摘Prevailing tissue degeneration caused by musculoskeletal maladies poses a great demand on bioscaffolds,which are artificial,biocompatible structures implanted into human bodies with appropriate mechanical properties.Recent advances in additive manufacturing,i.e.,3D printing,facilitated the fabrication of bioscaffolds with unprecedented geometrical complexity and size flexibility and allowed for the fabrication of topologies that would not have been achieved otherwise.In our work,we explored the effect of porosity on themechanical properties of a periodic cellular structure.The structure was derived from the mathematically created triply periodic minimal surface(TPMS),namely the Sheet-Diamond topology.First,we employed a series of software including MathMod,Meshmixer,Netfabb and Cura to design the model.Then,we utilized additive manufacturing technology to fabricate the cellular structures with designated scale.Finally,we performed compressive testing to deduce the mechanical properties of each cellular structure.Results showed that,in comparison with the highporosity group,the yield strength of the low-porosity group was 3 times higher,and the modulus was 2.5 times larger.Our experiments revealed a specific relationship between porosity and Young’s modulus of PLA-made Sheet-Diamond TPMS structure.Moreover,it was observed that the high-and low-porosity structures failed through distinctive mechanisms,with the former breaking down via buckling and the latter via micro-fracturing. | Zizhen Cai Zehua Liu Xiaodong Hu Hekun Kuang Jinsong Zhai | 2019 | Bio-Design and Manufacturing2019，2，4： | 1 |
| 4 | Adiponectin gene variation -4522C/T is associated with type 2 dia- betic obesity and insulin resistance in Chinese显示文摘 | Liu Hekun Chen Suyun Zhang Sizhong | 2007 | J Genet Genomics2007，34，： | 1 |
| 5 | DESI Legacy Imaging Surveys Data Release 9:Cosmological constraints from galaxy clustering and weak lensing using the minimal bias model显示文摘We present a tentative constraint on cosmological parameters Ω_(m) and σ_(8) from a joint analysis of galaxy clustering and galaxygalaxy lensing from DESI Legacy Imaging Surveys Data Release 9(DR9),covering approximately 10000 square degrees and spanning the redshift range of 0.1 to 0.9.To study the dependence of cosmological parameters on lens redshift,we divide lens galaxies into seven approximately volume-limited samples,each with an equal width in photometric redshift.To retrieve the intrinsic projected correlation function w_(p)(r_(p))from the lens samples,we employ a novel method to account for redshift uncertainties.Additionally,we measured the galaxy-galaxy lensing signal ΔΣ(r_(p))for each lens sample,using source galaxies selected from the shear catalog by applying our Fourier Quad pipeline to DR9 images.We model these observables within the flatΛCDM framework,employing the minimal bias model.To ensure the reliability of the minimal bias model,we apply conservative scale cuts:r_(p)>8 and 12 h^(-1)Mpc,for w_(p)(r_(p))and ΔΣ(r_(p)),respectively.Our findings suggest a mild tendency that S_(8)=σ_(8)√Ω_(m)/0.3increases with lens redshift,although this trend is only marginally significant.When we combine low redshift samples,the value of S8is determined to be 0.84±0.02,consistent with the Planck results but significantly higher than the 3×2 pt analysis by 2-5σ.Despite the fact that further refinements in measurements and modeling could improve the accuracy of our results,the consistency with standard values demonstrates the potential of our method for more precise and accurate cosmology in the future. | Haojie Xu Hekun Li Jun Zhang Xiaohu Yang Pengjie Zhang Min He Yizhou Gu Jian Qin Zhaozhou Li Antonios Katsianis Ji Yao Zhaoyu Wang Yirong Wang Liping Fu | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，12： | 0 |
| 6 | Experimental Study on the Penetration of Diesel and Biodiesel Spray Liquid Emerging from an Equilateral Triangular Orifice under Evaporative Conditions显示文摘This paper reports the results of an experimental study on the liquid phase characteristics of the biodiesel and diesel discharged from an equilateral triangular orifice and a circular orifice under different injection conditions by Mie-scattering imaging.The results revealed that the biodiesel liquid penetration length was longer than that of diesel under the same injection conditions.In addition,the increase of the chamber pressure was expected to enhance the interaction between air and fuel,resulting in the acceleration of the liquid phase breakup process.Moreover,with increasing chamber temperature,the liquid penetration of biodiesel was reduced less than that of diesel.This was due to the high surface tension and viscosity of biodiesel which inhibited the chamber air entrainment and suppressed the liquid breakup process.Accordingly,the higher probability of shorter diesel liquid penetration length indicated better air-fuel mixing than that of biodiesel.Besides,the triangular orifice liquid length was shorter than that of the circular orifice.And the stabilized liquid cone angle from the circular orifice was larger than that from the triangular orifice,indicating that using an equilateral triangular orifice has the potential to improve the air-fuel mixing process. | YIN Bifeng YE Ze JIA Hekun YU Shenghao DENG Weixin | 2022 | Journal of Thermal Science2022，31，5： | 0 |
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