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| 1 | 急性缺血性卒中的血管内治疗:神经介入外科学学会实践标准委员会的报告显示文摘目的总结采用血管内技术治疗急性缺血性卒中的有关证据并等级分类。方法对美国心脏协会(American Heart Association,AHA)以前发表的推荐意见进行审查并作为当前流程的基础。在此这基础上,进行系统的文献回顾以评估支持急性缺血性卒中血管内治疗的证据。根据AHA卒中委员会和牛津大学循证医学中心提出的循证医学证据分级指南进行评估。对操作安全性、技术效果以及对临床转归的影响进行特别审核。 | K A Blackham P M Meyers T A Abruzzo F C Alberquerque D Fiorella J Fraser D Frei C D Gandhi D V Heck J A Hirsch D P Hsu M Jayaraman S Narayanan C Prestigiacomo J L Sunshine 包元飞(译) 李永坤(译) 刘新峰(译) | 2012 | 国际脑血管病杂志2012，20，12： | 28 |
| 2 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 3 | Nuclear analogs of y$-lactam antibiotics I: The synthesis of 6/?-amidocyclonocardicins 显示文摘 | HECK J V CHRISRENSEN B G | 1981 | Tetra Lett1981，22，： | 1 |
| 4 | Parent and family impact of autism spectrum disorders:A review and proposed model for intervention evaluation显示文摘 | Karst JS Vaughan A Hecke V | 2012 | Clinical Child and Family Psyc2012，15，3： | 1 |
| 5 | Granular matter:A tale of tails显示文摘 | | 2005 | Nature2005，435，7045： | 1 |
| 6 | Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura 显示文摘 | Yu J Heck S Patel V | 2008 | Blood2008，112，4： | 1 |
| 7 | Homocysteins, Sadenosyl methionine and S-adenosyl homocysteine are associated with retinal microvascular abnormalities: the Hoorn Study 显示文摘 | VAN HECKE M V DEKKER J M NIJPELS G | 2008 | Clin Sci(Lond)2008，114，7： | 1 |
| 8 | Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura显示文摘 | Yu J Heck S Patel V | 2008 | Blood2008，112，4： | 1 |
| 9 | Production and characterization of slow pyrolysis biochar influence of feedstock type and pyrolysis conditions显示文摘 | Ronsse F Hecke S V Dickinson D et ol | 2013 | Global Change Biology Bioenergy2013，5，2： | 1 |
| 10 | Diabetic retinopathy is associated with mortality and cardiovascular disease incidence;the EURODIAB prospective complications study显示文摘 | van Hecke M V Dekker J M Stehouwer C D | | 0，，6： | 1 |
| 11 | Increased oxidative and nitrosative reactions during digestion could contribute to the association between well-done red meat consumption and colorectal cancer显示文摘 | HECKE T V VOSSEN E HEMERYCK L Y | 2015 | Food Chemistry2015，187，： | 1 |
| 12 | Reaching conditions for variable structure control with output feedback显示文摘 | Yallapragada S V Heck B S and Finney J D | 1996 | Journal of Guidance Control and Dynamics1996，19，4： | 1 |
| 13 | Estrogen-related receptor alpha expression and function is associated with the transcriptional coregulator AIB1 in breast carcinoma显示文摘 | HECK S ROM J THEWES V | | 0，，12： | 1 |
| 14 | Paraquat increases cyanide- insensitive respiration in murine lung epithelial cells by activating an NAD(P) H : Paraquat Oxidoreductase : Identification of the enzyme as thioredox in reductase 显示文摘 | Gray J P Heck D E Mishin V | 2007 | J Biol Chem2007，282，： | 1 |
| 15 | TRIP-Effects in Austempered Ductile Irons显示文摘 | Hecke P V Penning J | 2001 | Int Conf on TRIP-Aided High Strength Ferrous Alloys2001，，6： | 1 |
| 16 | Defective circulating CD25regulatory T cells in patients with chronic immune thrombocytopenic purpura 显示文摘 | w Yu J Heck S Patel V | 2008 | Blood2008，112，4： | 1 |
| 17 | An Open Platform for Reconfigurable Control 显示文摘 | Kannan S Sander S Guler M Heck B Prasad J V R Schrage D Vachtsevanos G | 2001 | IEEE Control System Magazine2001，，6： | 1 |
| 18 | 查看详情显示文摘 | Percec V Heck J Tomazos D Falkenberg F Blackwell H Ungar G.Jr | | 0，，： | 1 |
| 19 | Homocys- teins, sadenosyl methionine and S - adenosyl homocysteine are as- sociated with retinal microrascular abnormalities: the hoom study 显示文摘 | VAN HECKE M V DEKKER J M NIJPEL S G | 2008 | Clin Sci (Lond)2008，114，7： | 1 |
| 20 | Increased oxidative and nitrosative reactions during digestion could contribute to the association between well-done red meat consumption and colorectal cancer显示文摘 | HECKE T V VOSSEN E HEMERYCK L Y | 2015 | Food Chemistry2015，187，： | 1 |
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