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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | 2012 (9859)2012，，9859： | 3 |
| 3 | Abdominal ultrasonography of the pediatric gastrointestinal tract显示文摘Ultrasound is an invaluable imaging modality in the evaluation of pediatric gastrointestinal pathology; it can provide real-time evaluation of the bowel without the need for sedation or intravenous contrast. Recent improvements in ultrasound technique can be utilized to improve detection of bowel pathology in children: Higher resolution probes, color Doppler, harmonic and panoramic imaging are excellent tools in this setting. Graded compression and cine clips provide dynamic information and oral and intravenous contrast agents aid in detection of bowel wall pathology. Ultrasound of the bowel in children is typically a targeted exam; common indications include evaluation for appendicitis, pyloric stenosis and intussusception. Bowel abnormalities that are detected prenatally can be evaluated after birth with ultrasound. Likewise, acquired conditions such as bowel hematoma, bowel infections and hernias can be detected with ultrasound. Rare bowel neoplasms, vascular disorders and foreign bodies may first be detected with sonography, as well. At some centers, comprehensive exams of the gastrointestinal tract are performed on children with inflammatory bowel disease and celiac disease to evaluate for disease activity or to confirm the diagnosis. The goal of this article is to review up-to-date imaging techniques, normal sonographic anatomy, and characteristic sonographic features of common and uncommon disorders affecting the gastrointestinal tract in children. | Heather I Gale Michael S Gee Sjirk J Westra Katherine Nimkin | 2016 | World Journal of Radiology2016，8，7： | 3 |
| 4 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet2012，，9859： | 2 |
| 5 | Cultual practices for managing Bemisia tabaci and associated viral diseases显示文摘 | LUKO HIJI HEATHER S COSTA H S | 2001 | Crop Protection2001，20，： | 1 |
| 6 | Intravenous levetiracetam in critically ill children with status epilepticus or acute repetitive seizures 显示文摘 | Nicholas S Abend MD Heather M | 2009 | Pediatr Crit Care Med2009，10，4： | 1 |
| 7 | Oxidative stress markers are associated with persistent atrial fibrillation显示文摘 | Robert B Heather L Irfan S | 2007 | Clin Chem2007，53，9： | 1 |
| 8 | Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo:role of P-selectin显示文摘 | Vandana S D Wolfgang B Heather A M | 2005 | Blood2005，106，7： | 1 |
| 9 | Studies on the microbial populations of the rhizosphere of big sagebrush (Artemisia tridentata)显示文摘 | Antony J B Janice L S Heather M K | 2004 | Journal Indian Microbiology and Biotechnology2004，31，6： | 1 |
| 10 | The immunomodulatory agents lenalidomide and thalidomide for treatment of the myelodysplastic syndromes:A clinical practice guideline显示文摘 | Heather AL Rena B April S | 2013 | Critical Reviews in Oncology/Hematology2013，85，2： | 1 |
| 11 | The impact of nursing work envi- ronments on patient safety outcomes:the mediating role of burnout en- gagement显示文摘 | Laschinger S Heather K Leiter M P | 2006 | J Nurs Adm2006，36，5： | 1 |
| 12 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010显示文摘 | Stephen S Lim Theo Vos Abraham D Flaxman Goodarz Danaei Kenji Shibuya Heather Adair-Rohani Mohammad A AlMazroa Markus Amann H Ross Anderson Kathryn G Andrews Martin Aryee Charles Atkinson Loraine J Bacchus Adil N Bahalim Kalpana Balakrishnan John Balmes S | 2012 | The Lancet . 2012 (9859)2012，，9859： | 1 |
| 13 | Impact of nasal ventilation on survival in hypercapnic Duchenne muscular dystrophy显示文摘 | Simonds AK Muntoni F Heather S | 1998 | Thorax1998，53，： | 1 |
| 14 | Analysis of home support andventilator ma-Lfunction in 1211 wentilator dependent patients显示文摘 | Chatwin M Heather S Hanak A | 2010 | Eur RespirJ2010，35，1： | 1 |
| 15 | Evaluating form and function of regional partnerships:applying social net work analysis to the network for a healthy california,2001-2007显示文摘 | Jennifer G Marcy S Heather K F | | 0，，04： | 1 |
| 16 | Statins and risk of incident diabetes:a collabrative meta-analysis of randomised statin trials显示文摘 | NAVEED S DAVID P HEATHER M M | 2010 | Lancet2010，375，： | 1 |
| 17 | Room temperature ionic liquids as novel media for 'clean' liquid-liquid extraction显示文摘 | Jonathan G H Heather D W Richard P S | 1998 | ChemicalCommunications1998，，16： | 1 |
| 18 | Single institution experience treating 104 vestibular schwannomas with fractionated stereotactic radiation therapy or stereotactic radiosurgery显示文摘 | Bethany M. Anderson Deepak Khuntia S?ren M. Bentzen Heather M. Geye Lori L. Hayes John S. Kuo Mustafa K. Baskaya Behnam Badie Amar Basavatia G. Mark Pyle Wolfgang A. Tomé Minesh P. Mehta | 2014 | Journal of Neuro-Oncology2014，，： | 1 |
| 19 | Administration of Wine and Grape Juice Inhibits In Vivo Platelet Activity and Thrombosis in Stenosed Canine Coronary Arteries 显示文摘 | HEATHER S DEMROW B S PETER R | 1995 | Circulation1995，91，： | 1 |
| 20 | Mindfulness meditation,well-being,and heart rate variability:a preliminary investigation into the impact of intensive Vipassana meditation显示文摘 | Krygier JR Heathers JA Shahrestani S | 2013 | Int J Psychophysiol2013，89，3： | 1 |
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