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| 1 | Renewable Energy Transmission by HVDC Across the Continent:System Challenges and Opportunities显示文摘Rapid development of renewable energy in China is driving a major shift in the characteristics and control requirements of the electricity grid.Since the best renewable energy resources are far away from load centers in the east and southeast,transmission over long distances is required.Over 20 high-voltage DC(HVDC)transmission lines,with a combined capacity exceeding 150 GW,are in operation or are currently under construction.This rapid expansion of new generation and transmission capacities based on power electronics starts to change the characteristics of the grid,especially in areas where they concentrate,creating new stability problems and operational challenges.New system theories and technologies are required to support the development and operation of a future grid that relies more and more on power electronics.This paper highlights the characteristics of power electronics as used in renewable energy generation and HVDC transmission systems,discusses the impacts of these power-electronics-based assets on grid stability and operational requirements,and identifies opportunities for the development of both new system theories and system technologies to support a national energy policy that emphasizes the use of clean energy. | Jian Sun Mingjie Li Zhigang Zhang Tao Xu Jingbo He Haijiao Wang Guanghui Li | 2017 | CSEE Journal of Power and Energy Systems2017，3，4： | 43 |
| 2 | Deformation mechanism and excavation process of large span intersection within deep soft rock roadway显示文摘The FLAC3D software was used to simulate and analyze numerically the displacement, stress and plastic zone distribu-tion characteristics of a large span intersection in a deep soft rock roadway after the surrounding rock was excavated. Our simula-tion results show that there are two kinds of dominating factors affecting roadway stability at points of intersection, one is the angle between horizontal stress and axial direction of the roadway and the other are the angles at the points of intersection. These results are based on a study we carried out as follows: first, we analyzed the failure mechanism of a large span intersection and then we built a mechanical model of a rock pillar at one of the points of intersection. At the end of this analysis, we obtained the failure characteristics of the critical parts on the large span intersection. Given these failure characteristics, we proposed a new supporting method, i.e., a Double-Bolt Control Technology (DBCT). By way of numerical simulation, DBCT can effectively control the deformation of the surrounding rock at the points of intersection in roadways. | LI Guofeng, HE Manchao, ZHANG Guofeng, TAO Zhigang Institute of Geotechnical Engineering, China University of Mining & Technology, Beijing 100083, China | 2010 | Mining Science and Technology2010，20，1： | 24 |
| 3 | Forming Limit Stress Diagram Prediction of Aluminum Alloy 5052 Based on GTN Model Parameters Determined by In Situ Tensile Test显示文摘常规形成限制图(FLD ) 被描述为主要紧张对次要的紧张的一个阴谋。然而, FLD 依赖于形成历史和紧张路径。在现在的学习,形成的限制基于压力的图(FLSD ) 被采用了预言铝合金(AA ) 的破裂限制 5052-O1 表。Nakazima 测试被组成的公式从修改 Gurson-Tvergaard-Needleman (GTN ) 模型导出的塑料模仿。一在里面 situ 有扫描电子显微镜(SEM ) 的张力的测试被建议决定在 GTN 的参数当模特儿。损坏进化被观察并且记录,并且 GTN 模型的参数通过在 AA5052-O1 的三个损坏阶段数空部分被识别。根据试验性的结果,原来的空体积部分,潜在的起核心作用的虚空的体积部分,批评空体积部分,在材料的最后的失败的空体积部分是被分配 0.002 918, 0.024 9, 0.030 103, 0.048 54 分别地。压力和紧张在快克前在最后装载的步被获得。AA5052-O1 的 FLSD 和 FLD 被阴谋。与试验性的 Nakazima 测试和单轴的张力的测试相比,预言的结果显示出一个好协议。参数决定了由在 situ,张力的测试能为可锻的金属被用于形成的限制的研究。 | HE Min LI Fuguo WANG Zhigang | 2011 | Chinese Journal of Aeronautics2011，24，3： | 20 |
| 4 | TRPV1 activation improves exercise endurance and energy metabolism through PGC-1α upregulation in mice显示文摘 | Zhidan Luo Liqun Ma Zhigang Zhao Hongbo He Dachun Yang Xiaoli Feng Shuangtao Ma Xiaoping Chen Tianqi Zhu Tingbing Cao Daoyan Liu Bernd Nilius Yu Huang Zhencheng Yan Zhiming Zhu | 2012 | Cell Research2012，22，3： | 18 |
| 5 | Effect of Reclamation Time and Land Use on Soil Properties in Changjiang River Estuary,China显示文摘The objective of this study is to analyze soil physical and chemical properties,soil comprehensive functions and impact factors after different years of reclamation.Based on the survey data taken from 216 soil sampling points in the Fengxian Reclamation Area of the Changjiang (Yangtze) River Estuary,China in April 2009 and remotely sensed TM data in 2006,while by virtue of multivariate analysis of variance (MANOVA),geo-statistical analysis (GA),prin-cipal component analysis (PCA) and canonical correspondence analysis (CCA),it was concluded that:1) With the in-crease in reclamation time,soil moisture,soil salinity,soil electric conductivity and soil particle size tended to decline,yet soil organic matter tended to increase.Soil available phosphorous tended to increase in the early reclamation period,yet it tended to decline after about 49 years of reclamation.Soil nitrate nitrogen,soil ammonia nitrogen and pH changed slightly in different reclamation years.Soil physical and chemical properties reached a steady state after about 30 years of reclamation.2) According to the results of PCA analysis,the weighted value (0.97 in total) that represents soil nutrient factors (soil nitrate nitrogen,soil organic matter,soil available phosphorous,soil ammonia nitrogen,pH and soil particle size) were higher than the weighted value (0.48 in total) of soil limiting factors (soil salinity,soil elec-tric conductivity and soil moisture).The higher the F value is,the better the soil quality is.3) Different land use types play different roles in the soil function maturity process,with farmlands providing the best contribution.4) Soil physi-cal and chemical properties in the reclamation area were mainly influenced by reclamation time,and then by land use types.The correlation (0.1905) of the composite index of soil function (F) with reclamation time was greater than that with land use types (-0.1161). | SUN Yongguang LI Xiuzhen ülo MANDER HE Yanlong JIA Yue MA Zhigang GUO Wenyong XIN Zaijun | 2011 | Chinese Geographical Science2011，21，4： | 17 |
| 6 | Effect of sintering temperature in argon atmosphere on microstructure and properties of 3D printed alumina ceramic cores显示文摘Alumina ceramics with different sintering temperatures in argon atmosphere were obtained using stereolithography-based 3D printing.The effects of sintering temperature on microstructure and physical and mechanical properties were investigated.The results show that the average particle size,shrinkage,bulk density,crystallite size,flexural strength,Vickers hardness,and nanoindentation hardness increased with the increase in sintering temperature,whereas the open porosity decreased with increasing sintering temperature.No change was observed in phase composition,chemical bond,atomic ratio,and surface roughness.For the sintered samples,the shrinkage in Z direction is much greater than that in X or Y direction.The optimum sintering temperature in argon atmosphere is 1350℃with a shrinkage of 3.0%,3.2%,and 5.5%in X,Y,and Z directions,respectively,flexural strength of 26.7 MPa,Vickers hardness of 198.5 HV,nanoindentation hardness of 33.1 GPa,bulk density of 2.5 g/cm^3,and open porosity of 33.8%.The optimum sintering temperature was 70℃higher than that sintering in air atmosphere when achieved the similar properties. | He LI Yongsheng LIU Yansong LIU Qingfeng ZENG Kehui HU Zhigang LU Jingjing LIANG | 2020 | Journal of Advanced Ceramics2020，9，2： | 13 |
| 7 | Effects of dietary yeast nucleotides on growth, non-specific immunity intestine growth and intestinal microbiota of juvenile hybrid tilapia Oreochromis niloticus ♀ × Oreochromis aureus ♂显示文摘This study investigated the effect of dietary supplementation of yeast nucleotides on the growth, nonspecific immunity, intestine growth and intestinal microbiota of juvenile hybrid tilapia. Tilapia(initial average weight of 8.02 g) was fed test diets supplemented with a yeast-originated nucleotide mixture(0,0.15, 0.30, 0.60, and 1.20 g/100 g diet) for 8 weeks. Fish fed the diet with 0.60% nucleotide had significantly higher weight gain than the control group(P < 0.05). Feed efficiency was improved in the fish fed 0.60 and 1.20% nucleotide compared with that in the control group. The optimal doses of nucleotides supplementation for growth and feed efficiency of fish were determined as 0.63 and 0.81%, respectively.Intestinal growth was improved in the 0.30 and 0.60% groups, as indicated by significant increase in intestine length. The fish fed 0.60 and 1.20% nucleotide showed higher super oxide dismutase(SOD)activity and lower malondialdehyde(MDA) level in the liver than the control fish, indicating enhancement of the anti-oxidant status. Serum lysozyme activity was significantly increased in the 0.15 and 0.3%nucleotide supplementation groups, suggesting an enhancement effect on the non-specific immune response. Lastly, dietary nucleotides supplementation exerted moderate influence on the intestinal microbiota of hybrid tilapia. A reduction in the cumulative abundance of putative butyrate-producing species was observed in the intestinal microbiota of fish fed diets with 0.60% nucleotide compared with the control, implying an interaction between dietary nucleotides and butyrate production. Briefly, dietary supplementation with 0.60% nucleotide improve the growth performance, immune activity and intestine growth in tilapia. | Li Xu Chao Ran Suxu He Jianli Zhang Jun Hu Yalin Yang Zhenyu Du Yanou Yang Zhigang Zhou | 2015 | Animal Nutrition2015，，3： | 12 |
| 8 | Antibiotic growth promoter olaquindox increases pathogen susceptibility in fish by inducing gut microbiota dysbiosis显示文摘Low dose antibiotics have been used as growth promoters in livestock and fish. The use of antibiotics has been associated with reduced pathogen infections in livestock. In contrast, antibiotic growth promoter has been suspected of leading to disease outbreaks in aquaculture. However, this phenomenon is circumstantial and has not been confirmed in experimental conditions. In this study,we showed that antibiotic olaquindox increased the susceptibility of zebrafish to A. hydrophila infection. Olaquindox led to profound alterations in the intestinal microbiota of zebrafish, with a drastic bloom of Enterobacter and diminishing of Cetobacterium. Moreover, the innate immune responses of zebrafish were compromised by olaquindox(P<0.05). Transfer of microbiota to GF zebrafish indicated that while the immuo-suppression effect of olaquindox is a combined effect mediated by both OLA-altered micro biota and direct action of the antibiotic(P<0.05), the increased pathogen susceptibility was driven by the OLA-altered microbiota and was not dependent on direct antibiotic effect. Taken together, these data indicate that low level of OLA induced gut microbiota dysbiosis in zebrafish, which led to increased pathogen susceptibility. | suxu he quanmin wang shuning li chao ran xiaoze guo zhen zhang zhigang zhou | 2017 | Science China(Life Sciences)2017，60，11： | 10 |
| 9 | Progress of regional oceanography study associated with western boundary current in the South China Sea显示文摘Recent progress of physical oceanography in the South China Sea (SCS) associated with the western boundary current (WBC) and eddies is reviewed in this paper. It includes Argo observations of the WBC, eddy detection in the WBC based on satellite images, cross-continental shelf exchange in the WBC, eddy-current interaction, interannual variability of the WBC, air-sea interaction, the SCS throughflow (SCSTF), among others. The WBC in the SCS is strong, and its structure, variability and dynamic processes on seasonal and interannual time scales are yet to be fully understood. In this paper, we summarize progresses on the variability of the WBC, eddy-current interaction, air-sea interaction, and the SCSTF achieved in the past few years. Firstly, using the drifting buoy observations, we point out that the WBC becomes stronger and narrower after it reaches the central Vietnam coast. The possible mechanisms influencing the ocean circulation in the northern SCS are discussed, and the dynamic mechanisms that induce the countercurrent in the region of northern branch of WBC in winter are also studied quantitatively using momentum balance. The geostropic component of the WBC was diagnosed using the ship observation along 18°N, and we found that the WBC changed significantly on interannual time scale. Secondly, using the ship observations, two anti-cyclonic eddies in the winter of 2003/2004 in the northern SCS, and three anti-cyclonic eddies in the summer of 2007 along 18°N were studied. The results show that the two anti-cyclonic eddies can propagate southwestward along the continental shelf at the speed of first Rossby wave (~0.1 ms-1 ) in winter, and the interaction between the three anti-cyclonic eddies in summer and the WBC in the SCS is preliminarily revealed. Eddies on the continental shelf of northern SCS propagated southeastward with a maximum speed of 0.09 ms-1 , and those to the east of Vietnam coast had the largest kinetic energy, both of which imply strong interaction between eddy activity and WBC in the SCS. Thirdly, strong intraseasonal variability (ISV) of sea surface temperature (SST) near the WBC regions was found, and the ISV signal of SST in winter weakens the ISV signal of latent heat flux by 20%. Fourthly, the long-term change of SCSTF volume transport and its connection with the ocean circulation in the Pacific were discussed. | WANG DongXiao LIU QinYan XIE Qiang HE ZhiGang ZHUANG Wei SHU YeQiang XIAO XianJun HONG Bo WU XiangYu SUI DanDan | 2013 | Chinese Science Bulletin2013，58，11： | 10 |
| 10 | NK cell education via nonclassical MHC and non-MHC ligands显示文摘生来的杀手(NK ) 房间教育,为完成功能的成熟和自我忍耐的一个过程,被在自我专业 histocompatibility 建筑群一级(MHC-I ) 之间的相互作用以前定义分子和他们的特定的禁止的受体。在过去的几年,种证据在 NK 房间教育加亮 nonclassical MHC-I 和 non-MHC-I 分子的重要角色。此处,我们考察 NK 房间教育的当前的知识,与 nonclassical MHC-I- 和 non-MHC-I-dependent 教育的一个特别焦点,并且把他们与古典 MHC-I-dependent 教育理论作比较。另外,我们更新并且由介绍限制模型扩大这个理论,重估数量和质量控制,并且阐明,讨论 cis 和 trans 特征在肿瘤和病毒感染的 NK 房间教育的冗余性。 | Yuke He Zhigang Tian | 2017 | Cellular & Molecular Immunology2017，14，4： | 9 |
| 11 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 12 | Pressure sintering of W-15wt.%Cu alloys prepared by mechanical alloying as a subsequent densification treatment method显示文摘The sintered W-15wt.%Cu alloys fabricated by mechanical alloying were re-sintered under pressure to increase the density and improve the properties of these alloys. The pressure was applied vertically along the axis of the sintered sample. Properties such as density, hardness, and bending strength were measured. The microstructures of the sintered bod- ies were observed. The results showed that the subsequent pressure sintering could increase the density of the sintered W-15wt.%Cu alloys. Their hardness, bending strength, and some other physical properties were also improved by this sub- sequent densification treatment. | LI Zhigang JIA Chengchang SUN Lan HE Yuntao FAN Shimin | 2006 | Rare Metals2006，25，2： | 8 |
| 13 | Principles of the roof cut short-arm beam mining method (110 method) and its mining-induced stress distribution显示文摘Since the 1960 s, mining science and technology in China has experienced two technical innovations, i.e.the ‘‘Masonry Beam Theory(MBT)' and ‘‘Transfer Rock Beam Theory(TRBT)'. Based on those theories, the conventional mining method(being called the 121 mining method) was established, consisting of excavating two tunnels with a pillar left for mining a working panel. However, with increasing mining depth,engineering geological disasters in the underground caverns have been frequently encountered. In addition, the use of the coal-pillar mining results in a large amount of coal resources unexploited. In order to address the problems above, the ‘‘Roof Cut Short-Arm Beam Theory(RCSBT), being called the 110 mining method)' was proposed by He Manchao in 2008. The 110 mining method features the mining of one coal seam panel, excavating necessarily only one roadway tunnel and leaving no pillars. Realization of the 110 mining method includes the following steps:(1) directional pre-splitting roof cutting,(2) supporting the roof by using high Constant Resistance Large Deformation bolt/cable(CRLD), and(3) blocking gangue by hydraulic props. This paper presents an overview of the principles, techniques and application of the 110 mining method. Special emphasis is placed on the numerical simulation of the geostress distribution found in the mining panel using the 110 method compared to that of the 121 method. In addition, the stress distribution on the ‘‘short beam' left by the roof cutting when performing the 110 method was also investigated using both numerical simulation and theoretical formulation. | Tao Zhigang Song Zhigang He Manchao Meng Zhigang Pang Shihui | 2018 | International Journal of Mining Science and Technology2018，28，3： | 8 |
| 14 | Frontsand strong currents of the upper southeast Indian Ocean显示文摘从卫星高度表导出的水道学的数据, ADCP 速度和海平面异例联合在东南印度洋被分析了。结果在区域在这些前面以内象水流的特征一样显示出主要海洋锋的地点和取向。两倍副热带的前面沿着 120 ° E 在节被观察,它与以前经常观察的正面的结构冲突 -- NorthSubtropical 前面(NSTF ) 和向南副热带的前面(SSTF ) 合并进单个 STF between110 °~ 1 15 ° E。Subantarctic 前面(SAF ) ,由 out-of-phase 影响了两倍旋涡,邂逅 48 ° S 在 120 °和 127 ° E 之间的三次。在 SAF 以内的表面流被这些旋涡的因地球自转而引起的效果加强直到 105.4 cm/s。而且,旋涡可以引起强壮的水流在 SAF 以内分开进二个分支。SAF 和主要极锋(PF1 ) 能在在 140 °和 145 ° E 之间的纬度与 about0.3 °的分离距离在 ADCP 数据个别地被识别,尽管他们不能在 thelow 决定独立被识别水道学的数据。不同 thermohaline 特征围绕天极深海(CDW ) 并且在在东南印度洋的南部的 AntarcticCircumpolar 当前的前面(SACCF ) 的形成的修改的围绕天极的深水(MCDW ) 结果。在它跑过伊丽莎白·特劳甘德公主以后,它一致地沿着 Kerguelen 高原的东方胁腹向北方转弯与一点季节变异 60 ° S 向北严厉地变得向南方。在东南 IndianOcean 的 ACC 的 SAF,主要 PF 和 SACCF 的地点和取向能被分发比由水道学的数据从 ADCP 数据导出的水流更精确识别,这被显示出,因为这些前面被强壮的水流通常伴随。然而, STF 和第二等的 PF 的地点和取向是更困难的通过当前的数据被鉴别,自从这二前面没被任何喷气通常伴随。第二等的 PF 通常是的 and 在上面的海洋和后者的开始几百米限制了的 STF 被 2 ℃的北终点经常决定等温。 | HE Zhigang DONG Zhaoqian YUAN Xiaojun | 2006 | Acta Oceanologica Sinica2006，25，2： | 7 |
| 15 | Effect of typhoon with extreme precipitation on mountain reservoir drinking water treatment: a case study in Ningbo, China显示文摘Due to frequent drinking water pollution accidents in the past decade, it is common that mountain reservoirs were used as the source of drinking water in China. However, some coastal areas frequently suffer from typhoon with extreme precipitation, which results in the water quality deterioration of the reservoirs. The influence of typhoons with extreme precipitation on Jiaokou reservoir and the emergency treatment process of Maojiaping water treatment plant in the past three typical typhoons with extreme precipitation from the year of 2012-2015 were studied. It was found that the degradation of water quality, such as the increase of turbidity and bacteria index, may not merely appear during the events, but last for several days. Changing the dosage of water purification agent, such as coagulant and disinfectant at right time and place may be an efficient emergency water treatment process. Based on the analysis of water quality variation rule during and after the events, it was also found that emergency treatment can be fully prepared before the arrival of a typhoon with extreme precipitation. And in order to better respond to the typhoon with extreme precipitation, several suggestions are also proposed in this paper as follows: establishing vegetated buffers at right place, such as macrophanerophytes,shrub or herbage, increasing investments in infrastructure management, merging or cancelling the small-scale water treatment plants, preparing adequate water purification agent before the typhoon comes, etc. | Wei Chen Zhengxie Zhou Jianrong He Hui Tao Zhigang Liu | 2017 | Chinese Journal of Population,Resources and Environment2017，15，2： | 7 |
| 16 | Kinetic characteristics of liquid phase sintering of mechanically activated W-15wt%Cu powder显示文摘The kinetic characteristics of W grain growth operated by diffusion controlled Oswald ripening (DOR) during liquid phase sintering were studied. A liquid phase sintering of W-15wt%Cu was carried out by pushing compacts into a furnace at the moment when the temperature increased to 1340°C for different sintering times. The results show that liquid phase sintering produces the compacts with considerably low relative density and inversely, rather high homogeneity. On the basis of the data extracted from the SEM images, the kinetic equation of W grain growth, G n = G 0n+ kt, is determined in which the grain growth exponent n is 3 and the grain growth rate constant k is 0.15 μm3/s. The cumulative normalized grain size distributions produced by different sintering times show self-similar. The cumulative distribution function is extracted from the curves by non-linear fitting. In addition, the sintering kinetic characteristics of W-15wt%Cu compacts were also investigated. | Zhigang Li Chengchang Jia Yuntao He Liliang Chen | 2006 | Journal of University of Science and Technology Beijing2006，13，4： | 7 |
| 17 | Compensation excavation method control for large deformation disaster of mountain soft rock tunnel显示文摘In recent years,the mine tunneling method and the new Austrian tunneling method have been considered the main theories of tunneling approaches in China.It is difficult for the traditional technique to overcome the large deformation problems imposed by complex geological conditions of mountain soft rock tunneling.Hence,the compensation excavation method has been proposed to solve this issue under the consideration that all damage in tunneling originates from the excavation.It uses supportive strategies to counteract the excavation effects successfully.This paper provides an overview of the fundamental ideas of the compensation excavation method,methodologies,and field applications.The scientific validity and feasibility of the compensation excavation method were investigated through the practical engineering study of the Muzhailing and Changning tunnels. | Manchao He Qiru Sui Mengnan Li Zhijiao Wang Zhigang Tao | 2022 | International Journal of Mining Science and Technology2022，32，5： | 6 |
| 18 | From Green Super Rice to green agriculture:Reaping the promise of functional genomics research显示文摘Producing sufficient food with finite resources to feed the growing global population while having a smaller impact on the environment has always been a great challenge.Here,we review the concept and practices of Green Super Rice(GSR)that have led to a paradigm shift in goals for crop genetic improvement and models of food production for promoting sustainable agriculture.The momentous achievements and global deliveries of GSR have been fueled by the integration of abundant genetic resources,functional gene discoveries,and innovative breeding techniques with precise gene and whole-genome selection and efficient agronomic management to promote resource-saving,environmentally friendly crop production systems.We also provide perspectives on new horizons in genomic breeding technologies geared toward delivering green and nutritious crop varieties to further enhance the development of green agricul-ture and better nourish the world population. | Sibin Yu Jauhar Ali Shaochuan Zhou Guangjun Ren Huaan Xie Jianlong Xu Xinqiao Yu Fasong Zhou Shaobing Peng Liangyong Ma Dingyang Yuan Zefu Li Dazhou Chen Ruifeng Zheng Zhigang Zhao Chengcai Chu Aiqing You Yu Wei Susong Zhu Qiongyao Gu Guangcun He Shigui Li Guifu Liu Changhua Liu Chaopu Zhang Jinghua Xiao Lijun Luo Zhikang Li Qifa Zhang | 2022 | Molecular Plant2022，15，1： | 6 |
| 19 | Intrinsic control of axon regeneration显示文摘Spinal cord injury disrupts the connections between the brain and spinal cord, often resulting in the loss of sensory and motor function below the lesion site. The most important reason for such permanent functional deficits is the failure of injured axons to regenerate after injury. In principle, the functional recovery could be achieved by two forms of axonal regrowth: the regeneration of lesioned axons which will reconnect with their original targets and the sprouting of spared axons that form new circuits and compensate for the lost function. Our recent studies reveal the activity of the mammalian target of rapamycin (mTOR) pathway, a major regulator of new protein synthesis, as a critical determinant of axon regrowth in the adult retinal ganglion neurons[1]. In this review, I summarize current understanding of the cellular and molecular mechanisms that control the intrinsic regenerative ability of mature neurons. | Zhigang He F.M. Kirby Neurobiology Center, Children’s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. | 2010 | The Journal of Biomedical Research2010，24，1： | 6 |
| 20 | Viscous-Flow-Based Analysis of Wave Near-Trapped in a Four-Cylinder Structure显示文摘The hydrodynamic analysis of multi-floating bodies is important and widely used in marine engineering. In this study, we systematically simulated the wave diffraction problem of a fixed vertical four-cylinder structure in regular waves in the time domain in a viscous numerical wave tank. The hydrodynamic interaction of waves with a bottom-mounted structure consisting of four vertical cylinders arranged at the corners of a square shows a complicated interference phenomenon. In this paper, we illustrate and analyze the run-up around the structure and the corresponding wave forces. To investigate the viscous effect on the near-trapping phenomenon, we pay particular attention to investigating the waves near-trapped inside the four-cylinder structure,and make a comparative study of the viscous-and inviscid-flow solutions with the experimental measurements. The results show that the maximum wave elevation occurs on the inner side of the leeside cylinder, and that the wave elevations on the outer side of the cylinders are lower than those on the inner side. We can conclude that viscosity has an obvious damping effect on wave elevations inside the structure. The cylinders show a tendency to drift apart from each other when the near-trapping phenomenon occurs. | Zhengke Wang Guanghua He Zhigang Zhang Yanghan Meng | 2018 | Journal of Marine Science and Application2018，17，3： | 5 |
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