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| 1 | Rehabilitation and Sustainable Use Pattern of Rocky-desertified Land in Southwest China’s Poverty-stricken Karst Mountainous Areas——A Case Study in Benggu Township, Xichou County, Yunnan, China显示文摘The rocky desert in a karst area directly causes the lack of soil, water and forest, hence leading to the poverty there. In 1990, the villagers from the Muzhe Village in Benggu Township, Xichou County, Yunnan declared a war against rocky desert in an attempt to ask the fields for more yields. They invented a distinctive land rehabilitation and sustainable use pattern called “transforming heavenand earth” that had been practiced in Southwest China’s karst areas. The key mechanism of the pattern was to develop terraced fields with well conserved soil, water and fertility by exploding rocks in the fields, building stone walls, gathering more soil, and improving soil quality and productivity for the fields in combination with building of irrigation facilities and roads, as well as with forestation and agriculture structure adjustment. The purpose of the pattern was to alleviate poverty in the karst areas by improving soil productivity and promoting agriculturaldevelopment. A typical area was studied with the help of Participatory Rural Appraisal (PRA) and the pattern was carried out there for fifteen years, have produced excellent ecological benefits and good economic benefits. Its application in the area approved that it was a sustainable land use pattern for rocky desert areas. | YANG Zisheng LIU Yansui BAO Guangjing LI Zhiguo HE Yimei | 2006 | Journal of Mountain Science2006，3，3： | 10 |
| 2 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 3 | Ginsenoside Rb1 Reduces D-GalN/LPS-induced Acute Liver Injury by Regulating TLR4/NF-κB Signaling and NLRP3 Inflammasome显示文摘Background and Aims:The effect of ginsenoside Rb1 on D-galactosamine(D-GalN)/lipopolysaccharide(LPS)-induced acute liver injury(ALI)is unknown.The aim of this study was to evaluate the effect of ginsenoside Rb1 on ALI and its underlying mechanisms.Methods:Mice were pretreated with ginsenoside Rb1 by intraperitoneal injection for 3 days before D-GalN/LPS treatment,to induce ALI.The survival rate was monitored every hour for 24 h,and serum biochemical parameters,hepatic index and histopathological analysis were evaluated to measure the degree of liver injury.ELISA was used to detect oxidative stress and inflammatory cytokines in hepatic tissue and serum.Immunohistochemistry staining,RT-PCR and western blotting were performed to evaluate the expression of toll-like receptor 4(TLR4),nuclear factorkappa B(NF-κB),and NLR family,pyrin domain-containing 3 protein(NLRP3)in liver tissue and Kupffer cells(KCs).Results:Ginsenoside Rb1 improved survival with D-GalN/LPS-induced ALI by up to 80%,significantly ameliorated the increased alanine and aspartate transaminase,restored the hepatic pathological changes and reduced the levels of oxidative stress and inflammatory cytokines altered by D-GalN/LPS.Compared to the control group,the KCs were increased in the D-GalN/LPS groups but did not increase significantly with Rb1 pretreatment.D-GalN/LPS could upregulate while Rb1 pretreatment could downregulate the expression of interleukin(IL)-1β,IL-18,NLRP3,apoptosis associated specklike protein containing CARD(ASC)and caspase-1 in isolated KCs.Furthermore,ginsenoside Rb1 inhibited activation of the TLR4/NF-κB signaling pathway and NLRP3 inflammasome induced by D-GalN/LPS administration.Conclusions:Ginsenoside Rb1 protects mice against D-GalN/LPS-induced ALI by attenuating oxidative stress and the inflammatory response through the TLR4/NF-κB signaling pathway and NLRP3 inflammasome activation. | Yimei Liu Ninghua Liu Yujing Liu Hongyu He Zhe Luo Wenjun Liu Nan Song Minjie Ju | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 2 |
| 4 | The Mode of Promoting Industrial Targeted Poverty Alleviation through Land Circulation in Western Mountainous Region of China——A Case Study of Luquan Yi and Miao Autonomous County in Yunnan Province显示文摘In the industrial targeted poverty alleviation,land circulation is a key process. Based on the national strategy of targeted poverty alleviation,this paper combined the industrial development of targeted poverty alleviation with land circulation. According to the field survey on the current situation of land circulation and promotion of the industrial poverty alleviation in the typical project area of Zhongping Village in Zhongping Town and Jiaowuying Village in Jiulong Town in Luquan Yi and Miao Autonomous County in Yunnan Province,located in the high mountain canyon area of Jinsha River in the upper reaches of the Yangtze River in the west of China. This paper summarized and analyzed the organization and operation mechanism,basic practices and main results of the land circulation and promotion of industrial poverty alleviation model in the typical project area of the county. It also summarized the innovation and successful experience of the model,and then came up with measures to further promote the implementation of the model,so as to provide necessary reference for the implementation of land circulation and industrial targeted poverty alleviation for the poverty-stricken counties in Yunnan Province and similar provinces( cities,regions). | Jing LIU Zisheng YANG Ying XIONG Yanbo HE Chonghui LU Yimei HE Renyi YANG | 2019 | Asian Agricultural Research2019，11，2： | 1 |
| 5 | Theoretical Research on Cultivated Land Ecological Compensation Based on Targeted Poverty Alleviation and Development显示文摘The effectiveness of targeted poverty alleviation is related to whether China can build a well-off society on schedule. Poverty alleviation is an arduous and urgent major issue in China,and the Party and the government have always been very concerned about and attached importance to poverty alleviation. At present,China’s poverty alleviation and development faces enormous pressures and challenges. Some poor areas actually shoulder the heavy responsibility of ecological protection in the process of national development. The contradiction between economic development and ecological protection is intensifying. Objectively,these poor areas have made outstanding contributions and great sacrifices for the country’s ecological construction. Therefore,it is necessary to balance the two goals of poverty reduction and building an ecological environment and explore a win-win path that is in line with the actual ecological protection and poverty alleviation and development in poverty-stricken areas. Ecological compensation for poverty alleviation is one of the basic contents of the ' five-batch' project of China to implement poverty alleviation. Cultivated land is a very important ecosystem on land. On the basis of studying the ecological effects of cultivated land,the implementation of cultivated land ecological compensation has become an important part of the research on ecological poverty alleviation. On the one hand,ecological compensation for cultivated land can support or promote poverty alleviation and development. On the other hand,poverty alleviation and development policies also provide practical opportunities for cultivated land ecological compensation. Carrying out research on cultivated land ecological compensation and practicing this new direction and new poverty alleviation mode is of great significance to promote and improve the construction of ecological system for cultivated land,targeted poverty alleviation and development,and ecological protection of cultivated land. On the basis of combing the national ecological poverty alleviation strategy related policies and sorting out cultivated land ecological compensation theory research,this paper discusses the new mode of cultivated land ecological compensation to assist poverty alleviation and development,reveals the main problems in the current research and practice of cultivated land ecological compensation,and puts forward some suggestions for improving the ecological compensation for cultivated land to promote poverty alleviation and development. | Shiqin YANG Zisheng YANG Leijin LONG Meiqi SHAO Yimei HE | 2019 | Asian Agricultural Research2019，11，12： | 1 |
| 6 | Spatial and Temporal Variation of Real Integrated Land Productivity of Yunnan Province显示文摘Taking Yunnan Province as an example,this paper calculated the real integrated land productivity(RILP)of 16 prefectures(cities)in Yunnan Province for the past 11 years(2009-2019),and analyzed its spatial distribution pattern.The research results show that the RILP of the whole Yunnan Province and all prefectures(cities)showed a slow upward trend.Among them,the province's RILP showed the highest increase in 2019 compared with the previous year;the RILP of all prefectures(cities)in Yunnan Province has significant spatial autocorrelation,showing obvious positive spatial agglomeration characteristics.Based on this,this paper proposes to improve the overall RILP in various regions according to local conditions and formulate countermeasures for coordinated development of various prefectures(cities). | Shuocheng LIANG Zisheng YANG Renyi YANG Yimei HE | 2021 | Asian Agricultural Research2021，13，1： | 0 |
| 7 | Mepanipyrim induces visual developmental toxicity and vision-guided behavioral alteration in zebrafish larvae显示文摘Mepanipyrim,an anilinopyrimidine fungicide,has been extensively used to prevent fungal diseases in fruit culture.Currently,research on mepanipyrim-induced toxicity in organisms is still very scarce,especially visual developmental toxicity.Here,zebrafish larvae were employed to investigate mepanipyrim-induced visual developmental toxicity.Intense light andmonochromatic light stimuli-evoked escape experiments were used to investigate vision-guided behaviors.Meanwhile,transcriptomic sequencing and real-time quantitative PCR assays were applied to assess the potential mechanisms of mepanipyrim-induced visual developmental toxicity and vision-guided behavioral alteration.Our results showed that mepanipyrim exposure could induce retinal impairment and vision-guided behavioral alteration in larval zebrafish.In addition,the grk1b gene of the phototransduction signaling pathway was found to be a potential aryl hydrocarbon receptor(AhR)-regulated gene.Mepanipyrim-induced visual developmental toxicity was potentially related to the AhR signaling pathway.Furthermore,mepanipyrim-induced behavioral alteration was guided by the visual function,and the effects of mepanipyrim on long and middle wavelength light-sensitive opsins may be the main cause of vision-guided behavioral alteration.Our results provide insights into understanding the relationship between visual development and vision-guided behaviors induced by mepanipyrim exposure. | Chao Shen Yimei Cai Jialing Li Chengyong He Zhenghong Zuo | 2023 | Journal of Environmental Sciences2023，，2： | 0 |
| 8 | A Cobalt(Ⅲ)Corrole with a Tethered Imidazole for Boosted Electrocatalytic Oxygen Reduction Reaction显示文摘Developing electrocatalysts with high activity and selectivity for the oxygen reduction reaction(ORR)is vital to promote the performance of the next-generation energy technologies,which depend on the efficiency of the catalytic reduction of dioxygen.In the structure of cytochrome c oxidases(CcOs),a histidine imidazole residue binding to the axial position of Fe plays a crucial role in facilitating the selective reduction of O_(2)to water.Inspired by nature,we herein report on the synthesis of CoIII corrole 1 tethered with an imidazole ligand as well as its electrocatalytic ORR and O_(2)binding features.As compared to the imidazolium-free analogue,complex 1 displayed remarkably boosted activity for the selective four-electron/four-proton(4e-/4H+)ORR with a half-wave potential of E1/2=0.82 V versus reversible hydrogen electrode(RHE)in 0.1 mol/L KOH solutions.Importantly,we demonstrate that the tethered axial imidazole ligand improves the O_(2)binding ability of 1 thermodynamically and dynamically,which is crucial to boost electrocatalytic ORR performance.This work presents an example to improve electrocatalytic ORR activity and selectivity of Co corroles by introducing an axial imidazole ligand to enhance the O_(2)binding and activation. | Yimei Gao Benxing Mei Yizhen Wu Qian Zhao Zijia Bao Haonan Qin Yuhan Xu Haoyuan Lv Xinyang Peng Yan He Ting Luo Ran Yao Wei Zhang Haitao Lei Rui Cao | 2023 | Chinese Journal of Chemistry2023，41，21： | 0 |
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