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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | disturbance attenuation for state delayed systems 显示文摘 | Wang Q G Lee T H | 1998 | System & Control Letters1998，33，： | 1 |
| 3 | Mechanical properties of single crystal tungsten microwhiskers characterized by nanoindentation 显示文摘 | HUANG H WU Y Q WANG S L HE Y H ZOU J HUANG B Y LIU C T | 2009 | Materials Science and Engeering A2009，53，12： | 1 |
| 4 | 显示文摘 | He J B Lin X Q Pan J | 2005 | Electroanal2005，17，18： | 1 |
| 5 | Experimental study on the performance of CO2 residential air-conditioning system with anInternal heat exchanger显示文摘 | Tao Y B He Y L Tao W Q Wu Z G | | 0，，01： | 1 |
| 6 | Emergence, circulation, and spatiotemporal phylogenetie analysis of eoxsaekievirus a6 - and coxsackievirus al0 - associated hand, foot, and mouth disease infections from 2008 to 2012 in shenzhen, china显示文摘 | He Y Q Chen L Xu W B | 2013 | J Clin Microbiol2013，51，11： | 1 |
| 7 | Anti - inflammatory effect of hydrogen - rich saline in ao rat model of regional myocardial ische- mia and reperfusion显示文摘 | ZHANG Y SUN Q HE B | 2011 | Int J Cardiol2011，148，1： | 1 |
| 8 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 9 | Severe fever with thrombocytopenia syndrome,an emerging tick-brone zoonosis显示文摘 | Liu Q He B Huang S Y | 2014 | Lancet Infect Dis2014，14，70： | 1 |
| 10 | Natural variation in GS5 plays an important role in regulating grain size and yield in rice显示文摘 | Li Y B Fan C C Xing Y Z Jiang Y H Luo L J Sun L Shao D Xu C J Li X H Xiao J H He Y Q Zhang Q F | 2011 | Nature genetics2011，2，43： | 1 |
| 11 | Improved eellulariza- tion and angiogenesis using collagen scaffolds chemically con- jugated with vascular endothelial growth factor 显示文摘 | HE Q F ZHAO Y N CHEN B | 2011 | Acta Biomater2011，7，3： | 1 |
| 12 | Robust and timely communication over highly dynamic sensor networks 显示文摘 | He T Blum B M Cao Q | 2007 | Real-Time Systems2007，37，3： | 1 |
| 13 | Enantioselective liquid-liquid extraction ofzopielonewith mandelic acid ester derivatives显示文摘 | Peng Y He Q Zuo B | 2013 | Chirality2013，25，12： | 1 |
| 14 | Thelnfluence of Diffusion on Thermogravimetric Analysis of Carbon Black Oxidation 显示文摘 | Song Q He B Yao Q | 2006 | Energy and Fuels2006，20，6： | 1 |
| 15 | Discrete time analysis of MAP/PH/1 multiclass general preemptive priority queue显示文摘 | Alfa A Liu B He Q | 2003 | Naval Research Logistics2003，50，： | 1 |
| 16 | Polyphenol-gelatin interaction显示文摘 | Shi B He X Q Haslam E | 1994 | Journal American Leather Chemists Association1994，89，4： | 1 |
| 17 | Role of 1,2-dimethoxyethane in the transformation from ethylene polymerization to trimerization using chromium tris (2-ethylhexanoate)-based catalyst system:a DFT study显示文摘 | Qi Y Dong Q Zhong L Liu Z Qiu P Cheng R He X Vanderbilt J Liu B | | 0，，07： | 1 |
| 18 | N20 and N2 production during heterotrophic nitrification by Alcaligenes faecalis strain NR 显示文摘 | Zhao B An Q He Y L | 2012 | Bioresource Technology2012，116，： | 1 |
| 19 | Carboxymethylated chitosan stimulates proliferation of Schwann cells in vitro via the activation of the ERK and Akt signaling pathways显示文摘 | He B Liu SQ Chen Q | 2011 | Eur J Pharmacol2011，667，13： | 1 |
| 20 | Reliability sensitivity of automobile components with arbitrary distribution parameters显示文摘 | Zhang Y M He X D Liu Q L Wen B C Zheng J X | 2005 | Proceedings of the Institution of Mechanical Engineers Part D-Journal of Automobile Engineering2005，219，2： | 1 |
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