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| 1 | Portopulmonary hypertension and serum endothelin levels in hospitalized patients with cirrhosis显示文摘BACKGROUND:Cirrhosis is associated with several extrahepatic manifestations including portopulmonary hypertension (PPHT).Recent data suggest that endothelins (ETs) are related to the pathophysiology of PPHT.The study aimed to measure serum ET levels in hospitalized cirrhotic patients and to determine their association with PPHT and patient outcome.METHODS:Fifty-seven cirrhotic patients [43 males;median age 58 (28-87) years] underwent Doppler echocardiography.Patients with systolic pulmonary arterial pressure ≥40 mmHg and pulmonary acceleration time <100 ms were deemed to have PPHT.ET-1,2,and 3 serum levels were measured with an ELISA assay.All-cause mortality was recorded over a median period of 24 months.RESULTS:Nine out of 57 patients (15.8%) had PPHT.Among various clinical variables,only autoimmune hepatitis was associated with PPHT (OR=11.5;95% CI,1.58-83.4;P=0.01).ET-1 levels [9.1 (1.6-20.7) vs 2.5 (1.4-9.2) pg/mL,P=0.02] and the ET-1/ET-3 ratio [4.73 (0.9-22.4) vs 1.6 (0.3-10.7),P=0.02] were significantly higher in patients with PPHT than in those without.ET-2 and ET-3 levels did not differ between the two groups.There was no difference in survival between the two groups,although ET-1 levels were associated with an adverse outcome in Cox regression analysis (HR=1.11;95% CI,1.02-1.22;P=0.02 per unit increase in ET-1).CONCLUSION:Our data suggest that ET-1 and the ET-1/ET-3 ratio are elevated in patients with PPHT and that ET-1 is associated with a poor outcome irrespective of PPHT. | Aristotelis Tsiakalos Gregorios Hatzis Ioannis Moyssakis Aggelos Karatzaferis Panayiotis D Ziakas George E Tzelepis | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 2 | BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy显示文摘 | Cerchietti Leandro C Hatzi Katerina Caldas-Lopes Eloisi Yang Shao Ning Figueroa Maria E Morin Ryan D Hirst Martin Mendez Lourdes Shaknovich Rita Cole Philip A Bhalla Kapil Gascoyne Randy D Marra Marco Chiosis Gabriela Melnick Ari | 2010 | Journal of Clinical Investigation2010，，12： | 1 |
| 3 | The role of colongscopyin the differential hemorrhagic colitis显示文摘 | Mantzaris GJ Hatzis A Archavfis E | 1995 | Endoscopy1995，27，6： | 1 |
| 4 | The widespread expression of angiogenin in different human eeUs suggests a bio log ical funetio n not only related to angiogenesis显示文摘 | Gusse M Hatzi E | | Eur J Biochem0，226，： | 1 |
| 5 | The widespread expression of angiogenin in different human cells suggests a biological function not only related to angiogenesis显示文摘 | Gusse M Hatzi E | 1994 | Eur J Biochem1994，226，： | 1 |
| 6 | Synthesis and properties of poly ( lactic acid) 显示文摘 | ANDREOPOULOS A G HATZI E DOXASTAKIS M | 1999 | Journal of materials science : Materials in medicine1999，10，： | 1 |
| 7 | The widespread expression of angiogenin in different human cells suggests a biological function not only related to angiogenesis 显示文摘 | Moenner M Gusse M Hatzi E | 1994 | Eur J Bioehem1994，226，： | 1 |
| 8 | N-myc oncogene overexpres- sion downregulates IL-6; evidence that IL-6 inhibits angiogenesis and suppresses neurobalstoma tumor growth显示文摘 | Hatzi E Murphy C Zoephel A J | 2002 | Oncogene2002，21，22： | 1 |
| 9 | The widespread expression of angiogenin in different human cells suggests a biological function not only related to angiogenesis显示文摘 | Moenner M Gusse M Hatzi E | 1994 | Eur J Biochem1994，226，2： | 1 |
| 10 | Influence of FSHR diplotypes on ovarian response to standardgonadotropin stimulation for IVF∕ICSI显示文摘 | Lazaros L Hatzi E Xita N | 2013 | The Journal of reproductive medicine2013，58，910： | 1 |
| 11 | The widespread expression of angiogenin in different human cells suggests a biological function not only related to angiogenesis显示文摘 | MOENNER M GUSSE M HATZI E | 1994 | Eur J Biochem1994，226，2： | 1 |
| 12 | Adaptive Visual Analog Scales(AVAS)-a modifiable software program for the creation, administration, and scoring of visual analog scales显示文摘 | Marsh-Richard D M Hatzis E S Mathias C W | 2009 | Behav Res Methods2009，41，1： | 1 |
| 13 | BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy 显示文摘 | Cerchietti LC Hatzi K Caldas-Lopes E | 2010 | J Clin Invest2010，120，4： | 1 |
| 14 | CYP19 gene variants affect the assisted reproduction outcome of women with polycystie ovary syndrome显示文摘 | Lazaros L Xita N Hatzi E | 2013 | Gyneeol Endocrinol2013，29，5： | 1 |
| 15 | Angiogen in distribution in Human term placenta and expression by cultured trophoblast cells 显示文摘 | Pavlov N Hatzi E Bassaglia Y etal | 2003 | Angiongenesis2003，6，4： | 1 |
| 16 | Angiogen in distribution in human term placenta and expression by cultured trophoblast cells 显示文摘 | Pavlov N Hatzi E Bassaglia Y | 2003 | Angiongenesis2003，6，4： | 1 |
| 17 | Secretion of ribonucleases by normal and immortalized cells grown in serum-free culture conditions显示文摘 | Moenner M Hatzi E Badet J | 1997 | In Vitro Cell Dev Biol Anim1997，33，7： | 1 |
| 18 | Non - Invasive prenatal detection of paternal origin Hb lepore in a male fetus at the 7 th week of gestation显示文摘 | Lazaros L Hatzi E Bouba I | 2006 | Fetal Diagn Ther2006，21，6： | 1 |
| 19 | The role of colonoscopy in the differential diagnosis of acute severe hemorrhagic colitis 显示文摘 | Mantzaris GJ Hatzis A Arehavlis E | 1995 | Endoscopy1995，27，9： | 1 |
| 20 | Early enteral administration of immunonutrition in critically ill children:results of a blinded randomized controlled clinical trial显示文摘 | Briassoulis G Filippou O Hatzi E | 2005 | Nutrition2005，21，78： | 1 |
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