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| 1 | Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E显示文摘AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant genotype.METHODS: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct sequencing.RESULTS: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/E.The comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/E.CONCLUSION: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E. | Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi Ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，41： | 3 |
| 2 | Factor analysis of risk-taking behavior in forest work 显示文摘 | Inoue K Gotoh E Ishigaki I Hasegawa T | 1999 | Journal of Forest Research1999，4，3： | 1 |
| 3 | Isothermal imidization of an aromatic polyimide precursor studied by fluorescence spectroscopy显示文摘 | Hasegawa M Arai H Mira I | 1990 | Polym J1990，22，10： | 1 |
| 4 | Implication ofcardiac remodeling in heart failare - mechanisms and therapeutic strategies 显示文摘 | Takano H Hasegawa H Nagai T Komuro I | 2003 | Intern Med2003，42，6： | 1 |
| 5 | Enzymatic method for the simultaneous determination of hyaluronan and chondroitin sulfates using high-performance liquid chromatography 显示文摘 | Koshiishi I Takenouchi M Hasegawa T | 1998 | Anal Biochem1998，265，： | 1 |
| 6 | Effect of map strength on polarization mode dispersion in dispersion-managed soliton systems显示文摘 | Hirooka T Hasegawa A | 2000 | IEEE Photon Technol Lett2000，12，11： | 1 |
| 7 | Genetic improvement of heavy metal tolerance in plants by trander of the yeast metallothionein gene(CUP1)显示文摘 | Hasegawa I Terada E Sunairi M | 1997 | Plant Soil1997，196，： | 1 |
| 8 | Clinical evaluation of low molecular weight heparin (FR-860)on disseminated intravascular coagulation(DIC)-a multicenter cooperative double-blind trial in comparison with heparin显示文摘 | Saguragawa I Hasegawa H Maki M | 1993 | Thromb Res1993，72，： | 1 |
| 9 | Implica-tion of cardiac remodeling in heart failare-mechanismsand therapeutic strategies 显示文摘 | Takano H Hasegawa H Nagai T Komuro I | 2003 | Intern Med2003，42，6： | 1 |
| 10 | Genetic variants of human beta-defensin-1 and chronic obstructive pulmonary disease显示文摘 | Matsushita I Hasegawa K Nakata K | 2002 | Biochem Biophys Res Commun2002，291，1： | 1 |
| 11 | Cationic Polymerization of Alkyl-1,3-Butadienes 显示文摘 | Hasegawa K I Asami R Higashimura T | 1977 | Macromolecules1977，10，3： | 1 |
| 12 | Vapor Phase Preparation of Micro-coiled Carbon Fibers by Metal Powder Catalyzed Pyrolysis of Acetylene Containing a Small Amount of Phosphorus Impurity显示文摘 | Motojima S Hasegawa I Kagiya S | 1995 | Carbon1995，33，： | 1 |
| 13 | Ambroxol-induced modification of ion transport in human airway Calu-3 epithelia显示文摘 | Hasegawa I Niisato N Iwasaki Y | 2006 | Biochem Biophys Res Commun2006，343，2： | 1 |
| 14 | Color and translucency of in vivonatural central incisors显示文摘 | Hasegawa A Ikeda I Kawaguchi S | 2000 | J Prosthet Dent2000，83，4： | 1 |
| 15 | Reconstruction using a three - dimensional orbitozygomatic skeletal mod- el of titanium meshplate and soft - tissue flee flap transfer following totol maxillectomy 显示文摘 | Nakayama B Hasegawa Y Hyodo I | 2004 | Plast Reconstr Surg2004，114，3： | 1 |
| 16 | Reconstruction using a three-dimensional orbitezygomatic skeletal model of titanium mesh plate and soft-tissue free flap transfer following total maxillectomy显示文摘 | Nakayama B Hasegawa Y Hyodo I | 2004 | Plast Reconstr Surg2004，114，3： | 1 |
| 17 | Increased Macrolide Resistance of Myeoplasma pneumoniae in Pediatric Patient with Community- Acquired Pneumonia显示文摘 | Morozumi M : I wata S: Hasegawa K | 2008 | Antimicrobial Agents and Chemotherapy2008，，： | 1 |
| 18 | NSCAS Performance Training Journal显示文摘 | Hasegawa I | 2004 | Fitness Management2004，，11： | 1 |
| 19 | Reconstruction using a three-dimensional orbitozygomatic skeletal model of titanium mesh plate and soft-tissue free flap transfer following total maxillectomy显示文摘 | Nakayama B Hasegawa Y Hyodo I | 2004 | Plast Reconstr Surg2004，114，3： | 1 |
| 20 | Psychosocial stress augments tumor development through beta-adrenergic activation in mice显示文摘 | Hasegawa H Saiki I | 2002 | Jpn J Cancer Res2002，93，7： | 1 |
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