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| 1 | Stroke mechanisms and outcomes of isolated symptomatic basilar artery stenosis显示文摘background While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively,the prevalence,natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis(ISBAS)remain unknown.Methods We reviewed our prospective institutional database to identify patients with≥50% symptomatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or posterior cerebral arteries.Stroke mechanism,collateral circulation,and degree and length of stenosis were analysed.The primary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or death.Other outcome variables included modified Rankin Scale(mRS)score on discharge and last follow-up.results Of 6369 patients with AIS/TIA,91(1.43%)had ISBAS.Seventy-three(80.2%)patients presented with AIS and 18(19.8%)with TIA.Twenty-nine(31.9%)were women and the median age was 66.8±13.6 years.The mean follow-up time was 2.7 years.The most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by perforator occlusion(28.7%)and flow-dependent/hypoperfusion(15.1%).The percentage of stenosis was lower in patients who had favourable outcome compared with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p=0.007).Kaplan-Meier curves showed higher recurrence/death rates in patients with≥80% stenosis,mid-basilar location and poor collateral circulation.Approximately 13% of patients with ISBAS presented with complete BA occlusion.Conclusion ISBAS is an uncommon(1.43%)cause of TIA and AIS.Men in their 60s are mostly affected,and artery-to artery embolism is the most common stroke mechanism.Mid-basilar location,≥80% stenosis and poor collateral circulation are important factors associated with worse prognosis. | Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez Jorge A Roa David M Hasan Colin Derdeyn Biyue Dai Harold Adams Enrique Leira | 2019 | Stroke & Vascular Neurology2019，4，4： | 10 |
| 2 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 3 | Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial显示文摘 | Femke Mol Norah M van Mello Annika Strandell Karin Strandell Davor Jurkovic Jackie Ross Kurt T Barnhart Tamer M Yalcinkaya Harold R Verhoeve Giuseppe C M Graziosi Carolien A M Koks Ingmar Klinte Lars Hogstr?m Ineke C A H Janssen Harry Kragt Annemieke Hoek | 2014 | The Lancet2014，，： | 2 |
| 4 | Comparison of the efficacy and safety of rosuvastatin versus atorvastatin , simvastatin , and pravastatin across doses (STELLAR * * STELLAR = Statin Therapies for Elevated Lipid Levels compared Across doses to Rosuvastatin. Trial)显示文摘 | Peter H Jones Michael H Davidson Evan A Stein Harold E Bays James M McKenney Elinor Miller Valerie A Cain James W Blasetto | 2003 | The American Journal of Cardiology2003，，2： | 2 |
| 5 | Acinetobacter calcoaceticus genes involved in biosynthesis of the coenzyme pyrrolo-quinoline-quinone:nuleotide sequence and expression in Escherichia coli K-12显示文摘 | Goosen N Harold P A H Rene G M H | 1989 | J Bacteriol1989，171，1： | 1 |
| 6 | Usability analysis with Markov models 显示文摘 | Thimbleby Harold Cairns Paul A Jones Matt | 2001 | ACM Transactions on Computer-Human Interaction2001，8，2： | 1 |
| 7 | Isolation of anticoag ulant fractions from crude fucoidin显示文摘 | Georg F S Harold A W George M | 1957 | Experimental Biology and Medicine1957，94，2： | 1 |
| 8 | Flow and transport through clay membrane barriers显示文摘 | MICHAEL A MALUSIS CHARLES D SHACKELFORD HAROLD W OLSEN | 2003 | Engineering Geology2003，70，： | 1 |
| 9 | The Property Rights Paradigm显示文摘 | AEMEN A ALCHIAN HAROLD DEMSETZ | 1973 | The Journal of Economic History1973，33，3： | 1 |
| 10 | Differen- tial regulation of the oxidative llb-hydroxysteroid dehydrogenase activity in testis and liver显示文摘 | Nwe K H H Harold A Morat P B | 2000 | Ster- oids2000，65，1： | 1 |
| 11 | Acoustic,aerodynamic,and perceptual analyses of the voice of cochlear-implanted children显示文摘 | HAROLD A GUERRERO L MICHEL M | 2013 | J Voice2013，27，： | 1 |
| 12 | Influence of curingtemperature on the volatile components of peanuts显示文摘 | J A Singleon Harold E Pattee Elizabeth B Johns | 1971 | Agric Food hem1971，19，1： | 1 |
| 13 | Numerical Simulation and Experimental Analysis of Gas/Solid Flow Systems: 1999 Fluor-Daniel Plenary Lecture 显示文摘 | Harold A | 2001 | Powder Technology2001，，119： | 1 |
| 14 | TGF-β stimulation and inhibition of cell proliferation:new mechanistic insights 显示文摘 | Harold L Moses Edmund Y Yang Jennifer A Pletepol | 1990 | Cell1990，63，： | 1 |
| 15 | Wafer-Level Mechanical Characterization of Silicon Nitride MEMS显示文摘 | Kaushik A Harold Kahn | 2005 | Journal of Microelectromechanical Systems2005，14，2： | 1 |
| 16 | Morphological and separation performance study of polysulfone/titanium dioxide(PSF/TiO2 ) ultrafiltration membranes for humic acid removal显示文摘 | Harold N A A Ismail A F Matsuura T | 2011 | Desalination2011，273，1： | 1 |
| 17 | Site Qual:an Integrated Mea-sure of Web site quality显示文摘 | Harold W Webb Linda A Webb | | 0，，06： | 1 |
| 18 | Market power in water markets显示文摘 | Erik A Harold H | 2011 | Journal of Environmental Economics and Management2011，10，2： | 1 |
| 19 | The transient behavior of cascade thermoelectric heat pumps 显示文摘 | Richard P Bywaters Harold A Blum | 1970 | Energy Conversion1970，10，4： | 1 |
| 20 | Transmission-line properties of parallel wide strips by a conformal-nmpping approxhnation显示文摘 | Harold A Wheeler | 1964 | IEEE Trans- actions on Microwave Theory and Techniques1964，12，3： | 1 |
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