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| 1 | Mycophenolate mofetil for drug-induced vanishing bile duct syndrome显示文摘Amoxicillin/clavulanate is associated with liver injury, mostly of a cholestatic pattern. While outcomes are usually benign, progression to cirrhosis and death has been reported. The role of immunosuppressive therapy for patients with a protracted course is unclear. We report the case of an elderly patient who developed prolonged cholestasis secondary to amoxicillin/clavulanate. Vanishing bile duct syndrome was confirmed by sequential liver biopsies. The patient responded to prednisone treatment, but could not be weaned off corticosteroids, even when azathioprine was added. Complete withdrawal of both prednisone and azathioprine was possible by using mycophenolate mofetil, an inosine monophosphate dehydrogenase inhibitor. Sustained remission has been maintained for more than 3 years with low-dose mycophenolate mofetil. | S Simona Jakab A Brian West Dennis M Meighan Robert S Brown Jr William B Hale | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 2 | 利拉鲁肽与格列美脲在单药治疗2型糖尿病中的比较(LEAD-3 Mono):一项随机、双盲、平行分组、52周的Ⅲ期临床试验显示文摘背景 2型糖尿病新的治疗策略,需要针对胰岛素-葡萄糖的相互作用,且同时要降低体重增加和发生低血糖的风险。本文作者旨在调查利拉鲁肽单药治疗2型糖尿病的安全性与有效性。
方法 采用双盲、双模拟、治疗一对照、平行分组的研究,746例早期2型糖尿病患者被随机分配到1次/d利拉鲁肽组[1.2mg(n=251)或1.8mg(n=247)]或格列美脲8mg组(n=248),分别治疗52周。主要结局指标为糖化血红蛋白(HbA1c)的改变程度。采用意向性治疗进行分析。该试验在ClinicalTrials.gov网站的注册编码为NTC00294723.
结果52周时,格列美脲组HbA,。下降了0.51%(s=1.20),而利拉鲁肽1.2mg组下降了0.84%(s=1.23)(差值为-0.33.95%CI-0.53~-0.13;P=0.0014),利拉鲁肽1.8mg组下降了1.14%(S=1.24)(差值为-062,95%CI-0.83—-0.42;P〈0.0001)。利拉鲁肽1.2mg组和1.8mg组各有5例和1例患者因呕吐停止治疗,而格列美脲组未出现这种情况。
结论 利拉鲁肽作为2型糖尿病的初始治疗药物安全有效,与格列美脲相比更能降低HbA1c以及体重、血压和低血糖的发生率。 | Alan Garber Robert Henry Robert Rather Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvero-Alvarez Paula M Hale, Milan Zdravkovic Bruce Bode 邓斌(译) | 2009 | 世界临床医学2009，，6： | 5 |
| 3 | Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial显示文摘 | Alan Garber Robert Henry Robert Ratner Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvera-Alvarez Paula M Hale Milan Zdravkovic Bruce Bode | 2009 | The Lancet2009，，9662： | 2 |
| 4 | Autologous transplantation of CD133 selected hematopoietic progenitor cells for treatment of relapsed acute lymphoblastic leukemia显示文摘 | BARFIELD R C HALE G A BURNETTE K | 2007 | Pediatr Blood Cancer2007，48，3： | 1 |
| 5 | New approaches to high speed civil transport multidisciplinary design and optimization 显示文摘 | ZINK P Scott DAN A DeLaurentis MARK A Hale | 2000 | IEEE2000，，： | 1 |
| 6 | Competition for fluctuating nutrient显示文摘 | Hale J KM Somolinas A S | 1983 | Journal of Mathematical Biology1983，18，3： | 1 |
| 7 | Perturbation of homoclinies and subharmonics in Duffing' s equation 显示文摘 | Hale J K Spezamiglio A | 1985 | Nonlinear Anal : TMA1985，9，： | 1 |
| 8 | Interplay between active chromatin marks and RNA- directed DNA methylation in Arabidopsis thaliana 显示文摘 | GREENBERG M V DELERIS A HALE C J | 2013 | PLoS Genet2013，9，10： | 1 |
| 9 | DetaiLed polybrominated diphenyl ether(PBDE) congener composition of the widely used penta-, octa-, and deca-PBDE technical flame-retardant mixtures显示文摘 | LA A G M J HALE R C HARVEY E | 2006 | Environ Sci Technol2006，40，： | 1 |
| 10 | Collision Induced Dissociation of Fe2^+ 显示文摘 | Loh S K Lian L Hales D A | 1988 | J Phys Chem1988，92，： | 1 |
| 11 | Optimal simultaneous structural and control design of maneuvering flexible spacecraft 显示文摘 | Hale A L Dahl W E Lisowski R J | 1984 | Journal of Guidance Control and Dynamics1984，8，1： | 1 |
| 12 | Mucin gene (MUC1) transfered dendritic cells as vaccine: results of a phase I/II clinical trial显示文摘 | Pecher G Haling A Kaiser L | 2002 | Cancer Immunol Immunother2002，51，1112： | 1 |
| 13 | TGFβ induces morphological and molecular changes similar to human anterior subcapsular cataract显示文摘 | Lovicu F J Schulz M W Hales A M | 2002 | Br J Ophthalmol2002，86，2： | 1 |
| 14 | 显示文摘 | Morales A R Belfield K D Hales J M | 2006 | Chem Mater2006，18，： | 1 |
| 15 | The market for second-hand ships: Some results on efficiency using co-integration显示文摘 | Hale C Vanags A | 1992 | Maritime Policy and Management1992，18，1： | 1 |
| 16 | Manipulation of coupled osmotic flows for stabilization of shale exposed to water- based drilling fluids 显示文摘 | vanOort E Hale A H Mody F K | 1995 | SPE 304991995，，： | 1 |
| 17 | CCR5 antagonists:bicyclic isoxazolidines as conformationally constrained N-(l)-substituted pyrolidines显示文摘 | LYNCH C L GENTRY A L HALE J J | | 0，，04： | 1 |
| 18 | The predictive capaci- ty of perceived expressed emotion as a dynamic entity of adolescents from the general community 显示文摘 | Hale WW Raaijmakers QAW vanHoof A | 2011 | Soc Psychiatry Psychiatr Epidemiol2011，46，： | 1 |
| 19 | Modeling accidents for prioritizing prevention 显示文摘 | Hale A R Ale B J M Goossensa L H J | 2007 | Reliability Engineering and System Safety2007，92，12： | 1 |
| 20 | Assessment of Scenic Beauty of the Roadside Vegetation in Northern England显示文摘 | Akbar K F Hale W H G Headley A D | 2003 | Landscape and Urban Planning2003，，63： | 1 |
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