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| 1 | Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin显示文摘The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal hyperplasia.Similarly,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the skin.However,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains unknown.Here,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T cells.This activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/LFA-1.Naive T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 cells.In particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/CD2.The latter molecule initiated STAT1 signaling and IFN γproduction in T cells.Costimulation of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin disease.Consequently,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases. | Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag | 2020 | Cellular & Molecular Immunology2020，17，4： | 4 |
| 2 | Interleukin:a common endogenous mediator of information and the local shwqrtzman reaction显示文摘 | Beck G Habicht G S Benach J L | 1986 | J Immunol1986，136，： | 2 |
| 3 | Anthropometric reference data for international use:recommendations from a World Health Organization Expert Committee显示文摘 | DE ONIS M HABICHT J P | 1996 | A J Clin Nutr1996，64，： | 1 |
| 4 | Diversity of Sulfur Isotope Fractionations by Sulfate-Reducing Prokaryotes显示文摘 | Detmers J Brüchert V Habicht K S | 2001 | Applied and Environmental Microbiology2001，67，2： | 1 |
| 5 | Quantum chemical analysis of structure-activity relationships in nonsteroidal anti-inflammatory drugs 显示文摘 | Mahler E L Habicht J Brnne K | 1982 | Mol Pharmacol1982，22，3： | 1 |
| 6 | Sulfur isotope fraction- ation during bacterial reduction and disproportionation of thiosul- fate and sulfite 显示文摘 | Habicht K Canfield D E Ret hemeier J | 1998 | Geochimica et Cosmochimica Acta1998，62，15： | 1 |
| 7 | Capillary C4d deposition in kidney allografts: a specific marker of alloantibody-dependent graft injury显示文摘 | Bohmig G A Exner M Habicht A Schillinger M Lang U Kletzmayr J | 2002 | J Am Soc Nephrol2002，13，： | 1 |
| 8 | SulfurIsotope Fractionation During Bacterial Reduction andDisproportionation of Thiosulfate and Sulfite 显示文摘 | Habicht K S Canfield D E Rethmeier J | 1998 | Geochimica et Cosmochimica Acta1998，62，15： | 1 |
| 9 | An in vitro digestion/Caco-2 cell culture system accurately predicts the effects of ascorbic acidand polyphenolic compounds on iron bioavailability in humans显示文摘 | YUN S HABICHT J P MILLER D D | 2004 | Journalof Nutrition2004，134，10： | 1 |
| 10 | Diagnosis and treatment of invasive pulmonary aspergillosis in neutropenic patients显示文摘 | REICHENBERGER F HABICHT J M GRATWOHL A | 2002 | Eur Respir J2002，19，4： | 1 |
| 11 | Diagnostic yield of bronchoscopy in histologically proven invasive pulmonary aspergillosis显示文摘 | REICHENBERGER F HABICHT J MATT P | 1999 | Bone Marrow Transplant1999，24，11： | 1 |
| 12 | Anthropometric reference data for international use: Recommendation from a world health organization expert committee显示文摘 | de ONIS M HABICHT J | 2009 | Am J Clin Nutr2009，64，4： | 1 |
| 13 | Equity in Public Sector Primary Health Care:The Role of Service Organization in Indonesia显示文摘 | BERMAN P DANIEL G S Habicht J | 1989 | Economic Development and Cultural Change1989，，4： | 1 |
| 14 | Quantum chemical analysis of structure-activity relationships in nonsteroidal anti-inflammatory drugs显示文摘 | Mehler E L Habicht J Brune K | 1982 | Mol Pharmacol1982，22，3： | 1 |
| 15 | Lung resection for invasive pulmonary aspergillosis in neutropenic patients with hematologic diseases显示文摘 | Reichenberger F Habicht J Kaim A | 1998 | Am J Respir Crit Care Med1998，158，3： | 1 |
| 16 | An in vitrodigestion/Caco-2 cell culture system accurately predicts theeffects of ascorbic acid and polyphenolic compounds on ironbioavailability in humans 显示文摘 | Yun S Habicht J P Miller D D | 2004 | Journal of Nutrition2004，134，10： | 1 |
| 17 | Quantification of antidiabetic extracts and compounds in bitter gourd varieties显示文摘 | Habicht S D Kind V Rudloff S Borsch C Mueller A S Pallauf J Yang R Y Krawinkel M B | | 0，，： | 1 |
| 18 | Moderately and highly polymorphic microsatellites provide discordant estimates of population divergence in sockeye salmon,Oncorhynchus nerka显示文摘 | Olsen JB Habicht C Reynolds J Seeb JE | | 0，，： | 1 |
| 19 | The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant mode 显示文摘 | Ueno T Habicht A Clarkson M R Albin M J Yamaura K Boenisch O | 2008 | J Clin Invest2008，118，： | 1 |
| 20 | Physical adsorption on ferroelectric surfaces: photoinduced and thermal effects 显示文摘 | HABICHT S NEMANICHL R J GRUVERMAN A | 2008 | Nanotechnology2008，19，49： | 1 |
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