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| 1 | 自发性脑出血治疗指南美国心脏协会/美国卒中协会对医疗卫生专业人员发布的指南显示文摘目的本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法通过Medline进行规范的文献检索,利用证据表合并资料。撰写委员会成员通过远程电信会议讨论根据资料得出的推荐意见。采用美国心脏协会卒中委员会的证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南的草案进行发表前审阅。预期本指南在3年内完全更新。结果本文为脑出血患者的医疗诊治提供了循证指南。重点包括诊断、止血、血压管理、院内管理和护理、预防内科合并症、外科治疗、转归预测、康复、预防复发以及将来需要考虑的问题。结论脑出血是一种严重的疾病,早期积极救治可影响其转归。本指南为脑出血患者的目标导向治疗提供了一个框架。 | Lewis B. Morgenstem J. Claude Hemphill Ⅲ Craig Anderson Kyra Becker Joseph P. Broderick E. Sander Connolly Jr Steven M. Greenberg James N. Huang R. Loch Macdonald Steven R. Messe Pamela H. Mitchell Magdy Selim Rafael J. Tamargo 王玉洁(译) 王健(译) 刘相玉(译) 谢丽丽(译) | 2010 | 国际脑血管病杂志2010，，8： | 259 |
| 2 | Leptin: a multifunctional hormone显示文摘Leptin is the protein product encoded by the obese (ob)gene. It is a circulating hormone produced primarily by the adipose tissue. ob/ob mice with mutations of the gene encoding leptin become morbidly obese, infertile, hyperphagic, hypothermic,and diabetic. Since the cloning of leptin in 1994, our knowledge in body weight regulation and the role played by leptin has increased substantially. We now know that leptin signals through its receptor, OB-R, which is a member of the cytokine receptor superfamily. Leptin serves as an adiposity signal to inform the brain the adipose tissue mass in a negative feedback loop regulating food intake and energy expenditure. Leptin also plays important roles in angiogenesis, immune function, fertility and bone formation. Humans with mutations in the gene encoding leptin are also morbidly obese and respond to leptin treatment,demonstrating that enhancing or inhibiting leptin’s activities in vivo may have potential therapeutic benefits. | HUANG Lu, CAI LI(Tel: (214)-648-3340 Fax: (214)-648-9191 E-mail: li03@utsw.swmed.edu)(1 Touchstone Center for Diabetes Research1 Departments of Physiology and,2 Departments of Internal MedicineThe University of Texas Southwestern Medical Center5323 H. | 2000 | Cell Research2000，10，2： | 35 |
| 3 | Intracellular tat of human immunodeficiency virus type 1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus. Role of JAK/STAT signaling显示文摘 | Zeng, Y. Zhang, X. H. Huang, Z. Cheng, L. Yao, S. H. Qin, D. Chen, X. Y. Tang, Q. Lv, Z. G. Zhang, L. Lu, C. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 31 |
| 4 | Application and study in aluminum melt degassing technologies显示文摘The classification, characteristics and current situation of aluminum melt hydrogen-removal methods and technologies have been summarized. The latest studies and research results of aluminum melt degassing technology have been summed up. The tendency and prospect of aluminum degassing technology was discussed. | ~*H. J. Ni~(1,2), M. Y. Huang~1, Y. Zhu~1, P. Liao~1, R. Z. WU~2, B. D. Sun~2(1. Department of Mechanical Engineering, Nantong Institute of Technology, Nantong 226007, Jingsu, P. R. China 2. School of Material Science and Engineering, Shanghai Jiaotong University, Shanghai 200030, P. R. China) | 2004 | China Foundry2004，1，S1： | 27 |
| 5 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang Norden E. Shen Zheng Long Steven R. Wu Manli C. Shih Hsing H. Zheng Quanan Yen Nai-Chyuan Tung Chi Chao Liu Henry H | 1998 | Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences . 1998 (1971)1998，，1971： | 22 |
| 6 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang Norden E. Shen Zheng Long Steven R. Wu Manli C. Shih Hsing H. Zheng Quanan Yen Nai-Chyuan Tung Chi Chao Liu Henry H | 1998 | 1998 (1971)1998，，1971： | 18 |
| 7 | 抑郁症:应用MR动脉自旋标记法检测局部脑灌注变化显示文摘目的应用动脉自旋标记法(ASL)检测难治性抑郁症(RDD)、非难治性抑郁症(NDD)的局部脑灌注变化,并与健康对照组比较。方法本研究得到了当地伦理委员会批准,所有参加本研究的病人及志愿者均签署知情同意书。24例RDD、37例NDD以及42例健康对照者参加了本研究。从2006年2月-2007年7月.所有参与者均应用3TMR成像系统进行检查。对ASL和回波平面成像进行减影和平均以获得灌注加权像。采用基于体素的方法进行分析。感兴趣区放置在双侧海马、丘脑及豆状核。 | S. Lui L.M. Parkes X. Huang K. Zou R.C. Chore H. Yang 夏爽(译) 祁吉(校) | 2009 | 国际医学放射学杂志2009，32，4： | 18 |
| 8 | Effects of welding parameters and post-heat treatment on mechanical properties of friction stir welded AA2195-T8 Al-Li alloy显示文摘In this study, the effects of main welding parameters(rotation speed(ω) and welding speed(v)) on the microstructure, micro-hardness distribution and tensile properties of friction stir welded(FSW)2195-T8 Al-Li alloy were investigated. The effects of T6 post-treatments at different solution and aging conditions on the mechanical properties and microstructure characteristics of the FSW joints were also investigated. The results show that with increasing and v, both strength and elongation of the joints increase first, and then decrease with further increase of and v. All the joints under varied welding parameters show significant strength loss, and the strength reaches only 65% of the base metal. The effect of T6 post-heat treatment on the mechanical properties of the joints depends on the solution and aging conditions. Two heat treatment processes(480℃× 0.5 h quenching + 180℃× 12 h,520℃× 0.5 h quenching + 180℃× 12 h aging) are found to increase the joint strength. Furthermore,low temperature quenching(480℃) is more beneficial to the joint strength. The joint strength can reach 85% of the base metal. Whereas both low temperature aging(140℃× 56 h) and stepped aging(100℃× 12 h + 180℃× 3 h) processes decrease the joint strength. After heat treatment all the joints show decreased ductility due to the obvious grain coarsening in the nugget zone(NZ) and thermo-mechanically affected zone(TMAZ). | J. Zhang X.S. Feng J.S. Gao H. Huang Z.Q. Ma L.J. Guo | 2018 | Journal of Materials Science & Technology2018，34，1： | 16 |
| 9 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang Norden E. Shen Zheng Long Steven R. Wu Manli C. Shih Hsing H. Zheng Quanan Yen Nai-Chyuan Tung Chi Chao Liu Henry H | 1998 | Proceedings of the Royal Society A: Mathematical Physical and Engineering Sciences1998，，1971： | 15 |
| 10 | 利用拮抗细菌防治棉花黄萎病显示文摘本项目研究中,从植物根围、根表和植物内部分离到1345株细菌,并测定了他们对棉花黄萎病菌的抑菌性。118株细菌表现较强的抑菌性,抑菌率≥50%。其中25个菌株的抑菌率≥70%,93个菌株的抑菌率为50%70%。另外从棉花黄萎菌的微菌核际分离到57株细菌,其中30株细菌能显著地抑制棉花黄萎菌微菌核的菌落生长(5个菌株完全抑制微菌核的萌发和生长,15菌株的抑菌率为40%97%)。这些拮抗菌的培养滤液也能抑制棉花黄萎菌的生长。室内盆栽实验证明,应用拮抗菌处理棉花种子,有10个拮抗细菌能极显著地防治棉花黄萎病,其中4个菌株(ICB18、NCD2、CS25和CS27)的防病效果极好,防病效果为72.3%81.4%,3个菌株(C94、C28和NCD25)的防病效果为55.7%61.9%。19992000年的2年田间小区试验中,NCD2菌株对棉花黄萎病防治效果显著,并且显著优于国外商品化生防制剂TF,该菌株连续两年的防病效果平均为85.4%;另外4个菌株(ICB18、CS25、C94和C28)亦能显著防治棉花黄萎病,但防病效果与国外商品化生防制剂TF相当。在田间示范中,应用生防细菌NCD2制剂拌种后直接播种技术防治棉花黄萎病,防病效果达到51.2%。同时应用生防细菌NCD2制剂拌种育苗移栽技术防治棉花黄萎病,防病效果达到52.6%并且增产22.85%。本文同时测定了NCD2对主要大田作物的安全性,证明其对小麦、玉米、棉花、马铃薯、黄瓜、茄子和大豆等7种作物没有致病性,并且对这些作物的出苗、生长和发育没有不良影响。 | 李社增 鹿秀云 马平 高胜国 H. C. HUANG | 2005 | 山东科学2005，18，3： | 13 |
| 11 | The relative immunogenicity of DNA vaccines delivered by the intramuscular needle injection, electroporation and gene gun methods显示文摘 | Wang, S. X. | 2008 | 南京医科大学学报(自然科学版)2008，28，9： | 12 |
| 12 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang Norden E. Shen Zheng Long Steven R. Wu Manli C. Shih Hsing H. Zheng Quanan Yen Nai-Chyuan Tung Chi Chao Liu Henry H | 1998 | Proceedings of the Royal Society A: Mathematical Physical and Engineering Sciences1998，，1971： | 10 |
| 13 | Dynamics of Soil and Grain Micronutrients as Affected by Long-Term Fertilization in an Aquic Inceptisol显示文摘Micronutrient status in soils can be affected by long-term fertilization and intensive cropping.A 19-year experiment (1990-2008) was carried out to investigate the influence of different fertilization regimes on micronutrients in an Aquic Inceptisol and maize and wheat grains in Zhengzhou,China.The results showed that soil total Cu and Zn markedly declined after 19 years with application of N fertilizer alone.Soil total Fe and Mn were significantly increased mainly due to atmospheric deposition.Applications of P and organic fertilizer with incorporation of straws resulted in dramatic increases in soil total Cu,Zn,Fe,and Mn.Soil diethylenetriamine pentaacetic acid (DTPA)-extractable Cu in all treatments sharply decreased from initially 1.12 to about 0.8 mg kg -1 .The treatments with organic fertilizer had the highest soil DTPA-extractable Cu,Zn,Fe,and Mn after 19 years of cropping and fertilization,thus demonstrating the important role of organic fertilizer application in improving available micronutrient status.Cu and Zn contents in wheat grains in the no-P treatments were significantly higher than those of the treatments with P application.In addition,Fe and Mn contents in wheat grains were positively correlated with their soil DTPA-extractable concentrations.These indicated that the long-term application of organic fertilizer resulted in significant increases in soil total and available micronutrient concentrations and remarkable reduction in wheat grain Cu and Zn contents,which was due to high soil available P. | LI Ben-Yin HUANG Shao-Min WEI Ming-Bao H. L. ZHANG SHEN A-Lin XU Jian-Ming RUAN Xin-Ling | 2010 | Pedosphere2010，20，6： | 10 |
| 14 | Guidelines for the Management of Spontaneous Intracerebral Hemorrhage: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Lewis B. Morgenstern J. Claude Hemphill Craig Anderson Kyra Becker Joseph P. Broderick E. Sander Connolly Steven M. Greenberg James N. Huang R. Loch Macdonald Steven R. Messé Pamela H. Mitchell Magdy Selim Rafael J. Tamargo | 2010 | Stroke2010，，9： | 10 |
| 15 | Genome-wide Analysis of Transcriptional Variability in a Large Maize-Teosinte Population显示文摘基因表示规定在控制植物显型和改编起一个重要作用。这里,我们报导对通过 transcriptome 的基因表示变化的一个全面评价大 maize-teosinte 分析试验性的人口。染色体宽的印射识别了 25 ? 660 表示为 17 的量的特点 loci (eQTL )? 311 基因,捕获表示变化的一个崭新的范围。我们发现本地 eQTL 更经常被印射到邻近的基因,显示表示 piggybacking 的一个模式,它因而创造了共同调整的基因簇。在共同调整的基因簇以内的基因趋于有相关功能和分享的染色质修正。远 eQTL 与他们显著地在特定的功能的范畴充实的目标形成了 125 个重要远 eQTL 热点。由集成信息的不同来源,我们为许多新陈代谢的小径识别了通常认为的 trans- 管理者。我们证明 bHLH 抄写因素 R1 和 hexokinase HEX9 可能分别地为 flavonoid 生合成和 glycolysis 充当关键管理者。而且,我们证明驯服或改进显著地影响了全球基因表示,与选择指向的许多基因。特别兴趣,为生合成可能经历了的 benzoxazinoid 的 Bx 基因协调了在玉米和 teosinte 之间的 cis 规章的分叉,并且当玉米与一个不同草食动物社区传播了进适度的环境,使 Bx12 失去活性的 transposon 插入在强壮的选择下面。 | Xufeng Wang Qiuyue Chen Yaoyao Wu Zachary H. Lemmon Guanghui Xu Cheng Huang Yameng Liang Dingyi Xu Dan Li John F. Doebley Feng Tian | 2018 | Molecular Plant2018，11，3： | 7 |
| 16 | PLASMA MODEL-ONE MODEL OF ELECTROMAGNETIC RESPONSE OF MATTER显示文摘The prerequisite and mode of electromagnetic response of nano metal/dielectric films to electromagnetic wave field were suggested. With the carrier density and the reflectance, transmittance of the film, the plasma frequency and the dependence of absorptance on the frequency of electromagnetic wave field were calculated respectively. The calculated results accorded with the experimental ones, which proved the plasma resonance is one mode of electromagnetic response. | H. Du, J. Gong, C. Sun, A.L. Ji, R.F. Huang and L.S. Wen (The Department of Surface Engineering of Materials, Institute of Metal Research, The Chinese Academy of Sciences, Shenyang 110016, China) | 2001 | Acta Metallurgica Sinica(English Letters)2001，14，6： | 7 |
| 17 | NUMERICAL MODELING OF HEAVY METAL POLLUTANT TRANSPORT-TRANSFORMATION IN FLUVIAL RIVERS:A REVIEW显示文摘A detailed discussion of existing three kinds of mathematical models of heavy metal pollutant transport-transformation in fluvial rivers is presented, with an emphasis on the mathematical model of heavy metal pollutant transport-transformation dynamics. The imperfection of two kinds of mathematical models, that is, mathematical model of chemical thermodynamic equilibrium and that of chemical reaction kinetics, and the shortcoming of existing mathematical models of heavy metal pollutant transport-transformation dynamics are pointed out. Furthermore, the structure of mathematical model of heavy metal pollutant transport-transformation dynamics in fluvial rivers is suggested. Equations in the mathematical model of heavy metal pollutant transport-transformation dynamics in fluvial rivers will be discussed in the following paper. | S. L. HUANG Z. H. WAN P. SMITH | 2007 | International Journal of Sediment Research2007，22，1： | 5 |
| 18 | Posthepatectomy HBV Reactivation in Hepatitis B–Related Hepatocellular Carcinoma Influences Postoperative Survival in Patients With Preoperative Low HBV-DNA Levels显示文摘 | Gang Huang Eric C. H. Lai Wan Yee Lau Wei-ping Zhou Feng Shen Ze-ya Pan Si-yuan Fu Meng-chao Wu | 2013 | Annals of Surgery2013，，3： | 5 |
| 19 | An overview of the American trauma system显示文摘美国损伤系统被设计提供组织回答给损害。它从象在城市的社区医院里开发的原则一样在第 20 世纪的战争从美洲参与接受的教训拉它的基础。尽管在本地、州的政府水平跑,它被国家社会指导并且成为了一个世界级例子。它当前也面对 ? 有衰退偿还和提供的平等者的挑战存取喜欢所有美国人。职业社会和立法身体持续为这些问题的公平、公平的答案一起正在工作。 | Jose M. Soto Yilu Zhang Jason H. Huang Dong-Xia Feng | 2018 | Chinese Journal of Traumatology2018，21，2： | 5 |
| 20 | 5-Fluorouracil upregulates the activity of Wnt signaling pathway in CD133-positive colon cancer stem-like cells显示文摘Background and Objective:CD133-positive colon cancer stem like cells (CSLCs) are resistant to the conventional cytotoxic drug 5-fluorouracil (5-FU).Wnt signaling pathway plays important roles in colon cancer carcinogenesis and metastasis, and regulates the self-renewal capacity of CSLCs.In the present study, we explored the impact of 5-FU on Wnt signaling pathway of CD133-positive colon CSLCs, and the relation between Wnt signaling pathway and drug resistance of CD133-positive colon CSLCs.Methods:Magnetic activation cell separation was used to collect CD133-positive cells from colon cancer cell line DLD1, which was transfected with luciferase reporter for Wnt signaling activity.The activity of Wnt signaling pathway was compared between CD133-positive and CD133-negative cells.After the treatment with 1 μg/mL of 5-FU, the cell proliferation rates of DLD1 cells, CD133-positive cells, and CD133-negative cells were compared.After the treatment with 1 μg/mL and 10 μg/mL of 5-FU for 48 h, Wnt activity was compared between CD133-positive and CD133-negative cells.The expression of CD133 and cell apoptosis of CD133-positive cells was detected after exposure to 50 ng/mL of dickkopf (DKK)-1, a Wnt pathway inhibitor.Results:After the treatment with 5-FU, the cell proliferation rate of CD133-positive cells was higher than that of CD133-negative cells and the sensitivity of CD133-positive cells to 5-FU decreased.Wnt activity was higher in CD133-positive cells than in CD133-negative cells [(46.3±0.3)% vs.(33.9±2.7)%, P=0.009].After the treatment with 1 μg/mL and 10 μg/mL of 5-FU, Wnt activity of CD133-positive cells was (90.1±10.0)% (P=0.012) and (52.9±2.5)% (P=0.047), respectively, whereas that of CD133-negative cells was (35.5±3.3)% (P=0.434) and (26.5±0.4)% (P=0.046), respectively.CD133 expression in CD133-positive cells decreased from (87.2±5.3)% to (60.6±3.1)% (P=0.022) after treatment with DKK-1, whereas the cell apoptosis rate increased from (11.8±0.2)% to (28.3±0.6)% (P=0.013).Conclusions:Wnt activity is higher in CD133-positive DLD1 cells than in CD133-negative DLD1 cells.5-FU can upregulate Wnt activity of CD133-positive colon CSLCs.Blocking Wnt activity may reverse drug sensitivity of CD133-positive cells to 5-FU. | Yan-Hong Deng Xing-Xiang Pu Mei-Jin Huang Jian Xiao Jia-Ming Zhou Tong-Yu Lin Edward H. Lin | 2010 | Chinese Journal of Cancer2010，29，9： | 4 |
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