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| 1 | Cardiac implications of thrombotic thrombocytopenic purpura显示文摘Thrombotic thrombocytopenic purpura(TTP) is a multisystem disorder that essentially can affect any organ in the human body. The hallmark of the pathogenesis in TTP is the large von Willebrand factor multimers on plateletmediated micro-thrombi formation, leading to microvascular thrombosis.Autopsy studies showed that cardiac arrest and myocardial infarction are the most common immediate causes of death in these patients. Clinical manifestations of cardiac involvement in TTP vary dramatically, from asymptomatic elevation of cardiac biomarkers, to heart failure, MI and sudden cardiac death. There is limited knowledge about optimal cardiac evaluation and management in patients with TTP. The absence of typical cardiac symptoms,combined with complicated multi-organ involvement in TTP, may contribute to the under-utilization of cardiac evaluation and treatment. Prompt diagnosis and timely initiation of effective therapy could be critically important in selected cases. Based on our experience and this review of the literature, we developed several recommendations for focused cardiac evaluation for patients with acute TTP:(1) patients with suspected or confirmed TTP should be screened for the potential presence of cardiac involvement with detailed history and physical,electrocardiogram and cardiac enzymes;(2) clinical deterioration of TTP patients warrants immediate cardiac reevaluation;(3) TTP patients with clinical evidence of cardiac involvement should be monitored for telemetry, cardiac biomarkers and evaluated with transthoracic echocardiography. These patients require urgent targeted TTP treatment as well as cardiac-specific treatment. Aspirin therapy is indicated for all TTP patients. Since epicardial coronary artery involvement is rare, cardiac catheterization is usually not required, given the high risk for hemorrhage and kidney injury;(4) we recommend evidence-based medical therapy for ischemic symptoms and heart failure. TTP patients with evidence of cardiac involvement would also benefit from routine cardiology follow up during remission. | Szymon L Wiernek Bo Jiang Gregory M Gustafson Xuming Dai | 2018 | World Journal of Cardiology2018，10，12： | 2 |
| 2 | The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system显示文摘 | Sandrine Funes Joseph A Hedrick Galya Vassileva Lisa Markowitz Susan Abbondanzo Andrei Golovko Shijun Yang Frederick J Monsma Eric L Gustafson | 2003 | Biochemical and Biophysical Research Communications2003，，： | 2 |
| 3 | Elevated plasma homocysteine concentration in elderly patients with mental illness is mainly related to the presence of vascular disease and not the diagnosis 显示文摘 | Nilsson K Gustafson L Hultberg B | 2007 | Dement Geriatr Cngn Disord2007，24，3： | 1 |
| 4 | Sub-Hertz relative frequency stabilization of two-diode laser-pumped Nd: YAG lasers locked to a Fabry-Perot interferometer 显示文摘 | Eric K Gustafson Robert L Byer | 1992 | IEEE Journal of Quantum Electronics1992，28，4： | 1 |
| 5 | The complete nucleotide sequence of RNA beta from the type strain of Barley stripe mosaic virus显示文摘 | Gustafson G Armour S L | 1986 | Nucleic Acids Research1986，14，9： | 1 |
| 6 | Microstructure of model cermets with high Mo or W content显示文摘 | LINDAHL P GUSTAFSON P ROLANDER U STALS L ANDREN H O | 1999 | International Journal of Refractory Metals & Hard Materials1999，17，6： | 1 |
| 7 | Elevated plasma homo- cysteine level is not primarily related to alzheimer's disease 显示文摘 | Nilsson K Gustafson L Hultberg B | 2012 | Dement Geriatr Cogn Disord2012，34，2： | 1 |
| 8 | Reevaluating amdahl's law 显示文摘 | Gustafson J L | 1988 | Communications of the ACM1988，31，5： | 1 |
| 9 | Post-Kombolgie metasomatism at Jabiluka,Northern Territory,Australia,and its significance in the formation of high-grade uranium mineralization in lower proterozoic rocks显示文摘 | Gustafson L B Curtis L W | | 0，，1： | 1 |
| 10 | Plasma homocysteine and vascular disease in psychogeriatric patietlts 显示文摘 | Nilsson K Gustafson L Huhberg B | 2006 | Dement Geriatr Cogn Disord2006，21，3： | 1 |
| 11 | Reevaluating amdahl's law显示文摘 | Gustafson J L | 1988 | Commu- nications of the ACM1988，，31： | 1 |
| 12 | Cyclization kinetics ofpolyacrylonitrile显示文摘 | BELTZ L A GUSTAFSON R R | 1996 | Carbon1996，34，5： | 1 |
| 13 | Frontotemporal lobar degeneration:a consensus on clinical diagnostic criteria显示文摘 | Neary D Snowden J S Gustafson L | 1998 | Neurology1998，51，： | 1 |
| 14 | Plasma homocys-teine and vascular disease in psychogeriatric patiehts显示文摘 | Nilsson K Gustafson L Huhberg B | | 0，，03： | 1 |
| 15 | Subjective memory complaints, neuropsychological performance and psychiatric variables in memory clinic attendees: A 3-year follow-up study 显示文摘 | Elfgren C Gustafson L Vestberg S | 2010 | Arch Gerontol Geriatr2010，51，3： | 1 |
| 16 | A statistical grouting decision method based on water pressure tests for the tunnel construction stage-A case study显示文摘 | HERNQVIST L GUSTAFSON G FRANSSON A | 2013 | Tunnelling and underground space technology2013，，33： | 1 |
| 17 | Psychological wellbeing 3 years after severe-stroke显示文摘 | Lofgren B Gustafson Y Nyberg L | 1999 | Stroke1999，30，： | 1 |
| 18 | Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria 显示文摘 | Neary D Snowden JS Gustafson L | 1998 | Neurology1998，51，： | 1 |
| 19 | Toward a better parallel performance metric 显示文摘 | Sun X H Gustafson J L | 1991 | Parallel Computing1991，17，10： | 1 |
| 20 | Plasmahomocysteineis ele rated in elderly patients with memory complaints and vascular disease 显示文摘 | Nilsson K Gustafson L Huhberg B | 2007 | Dement Geriatr Cogn Disord2007，23，5： | 1 |
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