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| 1 | Current protective strategies in liver surgery显示文摘During liver resection surgery for cancer or liver transplantation,the liver is subject to ischaemia (reduction in blood flow) followed by reperfusion (restoration of blood flow),which results in liver injury [ischemiareperfusion (IR) or IR injury]. Modulation of IR injury can be achieved in various ways. These include hypothermia,ischaemic preconditioning (IPC) (brief cycles of ischaemia followed by reperfusion of the organ before the prolonged period of ischaemia i.e. a conditioning response),ischaemic postconditioning (conditioning after the prolonged period of ischaemia but before the reperfusion),pharmacological agents to decrease IR injury,genetic modulation of IR injury,and machine perfusion (pulsatile perfusion). Hypothermia decreases the metabolic functions and the oxygen consumption of organs. Static cold storage in University of Wisconsin solution reduces IR injury and has prolonged organ storage and improved the function of transplanted grafts. There is currently no evidence for any clinical advantage in the use of alternate solutions for static cold storage. Although experimental data from animal models suggest that IPC,ischaemic postconditioning,various pharma-cological agents,gene therapy,and machine perfusion decrease IR injury,none of these interventions can be recommended in clinical practice. This is because of the lack of randomized controlled trials assessing the safety and efficacy of ischaemic postconditioning,gene therapy,and machine perfusion. Randomized controlled trials and systematic reviews of randomized controlled trials assessing the safety and efficacy of IPC and various pharmacological agents have demonstrated biochemical or histological improvements but this has not translated to clinical benefit. Further well designed randomized controlled trials are necessary to assess the various new protective strategies in liver resection. | Kurinchi S Gurusamy Hector D Gonzalez Brian R Davidson | 2010 | World Journal of Gastroenterology2010，16，48： | 7 |
| 2 | Long term properties under marine exposure of steel fiber reinforced concrete containing PFA 显示文摘 | MANGAT D S GURUSAMY K | 1988 | Materials and Structures1988，21，125： | 1 |
| 3 | Targeted delivery of low moleculardrugs using chitosan and its derivatives显示文摘 | Jae H P Gurusamy S Kwangmeyung K | 2010 | Advanced Drug Delivery Revie-ws2010，62，： | 1 |
| 4 | Chloride diffusion in steelfiber reinforced marine concrete显示文摘 | MANGAT D S GURUSAMY K | 1988 | Cement and Concrete Research1988，18，3： | 1 |
| 5 | Long-term properties of steel fibre reinforced marine concrete 显示文摘 | MNGAT P S GURUSAMY K | 1987 | Materials and structures1987，20，118： | 1 |
| 6 | T-tube drainage versus primary closure after open common bile duct explora- tion 显示文摘 | GURUSAMY K S KOTI R DAVIDSON B R | 2013 | Cochrane Database Syst Rev2013，21，00： | 1 |
| 7 | Long term properties under marine exposure of steel fiber reinforced concrete containing PFA显示文摘 | MANGAT D S GURUSAMY K | 1988 | Materials and Structures1988，24，5： | 1 |
| 8 | Meta-analysis of randomized eontrolled trials on the safety and effectiveness of day-case laparo- scopic cholecystectomy显示文摘 | Gurusamy K Junnarkar S Farouk M | 2008 | Br J Surg2008，95，2： | 1 |
| 9 | Chloride diffusion in steel fiber reinforced marine eoncrete显示文摘 | MANGAT P S GURUSAMY K | 1998 | Cement and Concrete Research1998，17，3： | 1 |
| 10 | Three dimensional two dimensional imaging for laparoscopic :holecystectomy显示文摘 | Gurusamy KS Sahay S Davidson BR | 2011 | Cochrane Database Syst Rev2011，19，1： | 1 |
| 11 | Cardioprotection by resveratrol:a novel mechanism via autophagy involving the m TORC2 pathway显示文摘 | Gurusamy N Lekli I Mukherjee S | 2010 | Cardiovasc Res2010，86，1： | 1 |
| 12 | Three dimensional versus two dimensional imaging for laparoscopic cholecystectomy显示文摘 | Gurusamy KS Sahay S Davidson BR | 2011 | Cochrane Database Syst Rev2011，，00： | 1 |
| 13 | UK guidelines for the mangement of acute panceatitis 显示文摘 | Gurusamy K S Farouk M Tweedie J H | 2005 | Gut2005，54，3： | 1 |
| 14 | Arthroplasty with and (without bone cement) for proximal femoral fractures in aduhs显示文摘 | Parker MJ Gurusamy KS Azegami S | 2010 | Cochrance Database Syst Rev2010，6，4： | 1 |
| 15 | Chloride diffusion in steel fiber reinforced marine concrete显示文摘 | MANGAT P S GURUSAMY K | 1987 | Cement and Concrete Research1987，17，3： | 1 |
| 16 | Permissible crack widths in steel fi- bre reinforced marine concrete显示文摘 | Mangat P S Gurusamy K | 1987 | Materials and structures1987，20，5： | 1 |
| 17 | Effect of cavity depth on stresses in a restored tooth显示文摘 | Goel VK Khera SC Gurusami S | 1992 | J Prosthet Dent1992，67，2： | 1 |
| 18 | Three dimensional versus two dimensional imaging for laparoscopic chole- cystectomy显示文摘 | Gurusamy K Sahay S Davidson B | 2011 | Cochrane Database Syst Rev2011，19，1： | 1 |
| 19 | Methods to decrease blood loss and transfusion requirements for liver transplantation显示文摘 | GURUSAMY K S PISSANOU T PIKHART H | 2011 | Cochrane Database Syst Rev2011，，： | 1 |
| 20 | Effect of ADRB2 (adrenergic receptor 132) gene polymorphisms on the occurrence of asthma and on the response to nebulized salbutamol in South Indian patients with bronchial asthma显示文摘 | Shah NJ Vinod Kumar S Gurusamy U | 2015 | J Asthma2015，52，8： | 1 |
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