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您的检索式：作者名="Guoke Tang"
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| 1 | Formulation of pH-responsive PEGylated nanoparticles with high drug loading capacity and programmable drug release for enhanced antibacterial activity显示文摘In the current global crisis of antibiotic resistance,delivery systems are emerging to combat resistant bacteria in a more efficient manner.Despite the significant advances of antibiotic nanocarriers,many challenges like poor biocompatibility,premature drug release,suboptimal targeting to infection sites and short blood circulation time are still challenging.To achieve targeted drug delivery and enhance antibacterial activity,here we reported a kind of pH-responsive nanoparticles by simply self-assembly of an amphiphilic poly(ethylene glycol)-Schiff-vancomycin(PEG-Schiff-Van)prodrug and free Van in one drug delivery system.The acid-liable Schiff base furnished the PEG-Schiff-Van@Van with good storage stability in the neutral environment and susceptible disassembly in response to faintly acidic condition.Notably,on account of the combination of physical encapsulation and chemical conjugation of vancomycin,these nanocarriers with favorable biocompatibility and high drug loading capacity displayed a programmed drug release behavior,which was capable of rapidly reaching high drug concentration to effectively kill the bacteria at an early period and continuously exerting an bacteria-sensitive effect whenever needed over a long period.In addition,more Schiff-base moieties within the PEG-Schiff-Van@Van nanocarriers may also make great contributions on promoting the antimicrobial activity.Using this strategy,this system was designed to have programmable structural destabilization and sequential drug release due to changes in pH that were synonymous with bacterial infection sites,thereby presenting prominent antibacterial therapy both in vitro and in vivo.This work represents a synergistic strategy on offering important guidance to rational design of multifunctional antimicrobial vehicles,which would be a promising class of antimicrobial materials for potential clinical translation. | Dawei Li Guoke Tang Hui Yao Yuqi Zhu Changgui Shi Qiang Fu Fei Yang Xing Wang | 2022 | Bioactive Materials2022，7，10： | 1 |
| 2 | The dielectric behavior and efficient microwave absorption of doped nanoscale LaMnO_(3)at elevated temperature显示文摘LaMnO_(3)perovskite has great potential in microwave absorption at high temperature due to its complex doping effect and super stability.The current research mainly focuses on the doping ratio regulation,while the mechanism of doping effect at high temperature is still lack of sufficient investigation.In this work,La1−xSrxMn1−yFeyO_(3)(LaMnO_(3),La_(0.7)Sr_(0.3)MnO_(3),and La_(0.7)Sr_(0.3)Mn_(0.8)Fe_(0.2)O_(3))nanostructures with different doping sites were successfully prepared by the solid phase reaction method.Then,the high temperature dielectric test samples were obtained by mixing with cordierite(2MgO·2Al_(2)O_(3)·5SiO_(2)(MAS)).The results showed that the temperature dependence of Mn ion spin state had a significant impact on the high temperature dielectric behavior of La_(1−x)Sr_(x)Mn_(1−y)FeyO_(3).Particularly,when the thickness is only 1.9 mm,La_(0.7)Sr_(0.3)Mn_(0.8)Fe_(0.2)O_(3)/MAS can achieve the widest bandwidth of 4.2 GHz covered the entire X-band(8.2–12.4 GHz)and a minimum reflection loss(RL)value of−17.99 dB at 500℃.In order to improve the operating temperature of La_(0.7)Sr_(0.3)Mn_(0.8)Fe_(0.2)O_(3)/MAS,a cellular array structure was designed by using computer simulation technology(CST)software to introduce magnetic loss.When the outer length of the hexagon is 1 mm and the coating thickness is 1.9 mm,the widest bandwidth covers the X-band and the minimum RL value is−15.35 dB at 800℃.Therefore,La_(0.7)Sr_(0.3)Mn_(0.8)Fe_(0.2)O_(3)has a great prospect as an efficient high temperature microwave absorber. | Zhigang Mu Guoke Wei Hang Zhang Lu Gao Yue Zhao Shaolong Tang Guangbin Ji | 2022 | Nano Research2022，15，8： | 1 |
| 3 | pH-responsive delivery of H_(2) through ammonia borane-loaded mesoporous silica nanoparticles improves recovery after spinal cord injury by moderating oxidative stress and regulating microglial polarization显示文摘Imbalance of oxidative and inflammatory regulation is themain contributor to neurofunctional deterioration and failure of rebuilding spared neural networks after spinal cord injury(SCI).As an emerging biosafe strategy for protecting against oxidative and inflammatory damage,hydrogen(H_(2))therapy is a promising approach for improving the microenvironment to allow neural regeneration.However,achieving release of H_(2) at sufficient concentrations specifically into the injured area is critical for the therapeutic effect of H_(2).Thus,we assembled SiO_(2)@mSiO_(2) mesoporous silica nanoparticles and loaded them with ammonia borane(AB),which has abundant capacity and allows controllable release of H_(2) in an acid-dependent manner.The release of H_(2) from AB/SiO_(2)@mSiO_(2) was satisfactory at pH 6.6,which is approximately equal to the microenvironmental acidity after SCI.After AB/SiO_(2)@mSiO_(2) were intrathecally administered to ratmodels of SCI,continuous release of H_(2) fromthese nanoparticles synergistically enhanced neurofunctional recovery,reduced fibrotic scar formation and promoted neural regeneration by suppressing oxidative stress reaction.Furthermore,in the subacute phase of SCI,microglia were markedly polarized toward the M2 phenotype by H_(2) via inhibition of TLR9 expression in astrocytes.In conclusion,H_(2) delivery through AB/SiO_(2)@mSiO_(2) has the potential to efficiently treat SCI through comprehensivemodulation of the oxidative and inflammatory imbalance in themicroenvironment. | Yi Liu Yeying Wang Bing Xiao Guoke Tang Jiangming Yu Weiheng Wang Guohua Xu Xiaojian Ye | 2021 | Regenerative Biomaterials2021，8，6： | 0 |
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