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3篇 您的检索式:作者名="Gunter Weiss"
    题名 作者 年代 出处 被引量
1Dysregulation of iron and copper homeostasis in nonalcoholic fatty liver显示文摘Elevated iron stores as indicated by hyperferritinemiawith normal or mildly elevated transferrin saturation a n d m o s t l y m i l d h e p a t i c i r o n d e p o s i t i o n a r e a characteristic finding in subjects with non-alcoholic fatty liver disease(NAFLD). Excess iron is observed in approximately one third of NAFLD patients and is commonly referred to as the 'dysmetabolic iron overload syndrome'. Clinical evidence suggests that elevated body iron stores aggravate the clinical course of NAFLD with regard to liver-related and extrahepatic disease complications which relates to the fact that excess iron catalyses the formation of toxic hydroxylradicals subsequently resulting in cellular damage. Iron removal improves insulin sensitivity, delays the onset of type 2 diabetes mellitus, improves pathologic liver function tests and likewise ameliorates NAFLD histology. Several mechanisms contribute to pathologic iron accumulation in NAFLD. These include impaired iron export from hepatocytes and mesenchymal Kupffer cells as a consequence of imbalances in the concentrations of iron regulatory factors, such as hepcidin, cytokines, copper or other dietary factors. This review summarizes the knowledge about iron homeostasis in NAFLD and the rationale for its therapeutic implications.Elmar Aigner Gunter Weiss Christian Datz 2015World Journal of Hepatology2015,7,2:6
2Effect of neoadjuvant anthracycline–taxane-based chemotherapy in different biological breast cancer phenotypes: overall results from the GeparTrio study显示文摘Jens Huober Gunter Minckwitz Carsten Denkert Hans Tesch Erich Weiss Dirk Michael Zahm Antje Belau Fariba Khandan Maik Hauschild Christoph Thomssen Bernhard H?gel Silvia Darb-Esfahani Keyur Mehta Sibylle Loibl 2010Breast Cancer Research and Treatment2010,,1:1
3Current Status of Education of Deseriptive Geometry in Europe显示文摘In this paper the importance of eometry?and raphics?for the advancement of science and knowledge in 19th century is pointed out. Klein and Müller reform of geometry syllabus in 19th century and the education situation of Geometry and Graphics in Europe during the last third of 20th century are introduced. The problems of geometry and graphics education during the next decedes and six proposals are presented.Gunter Weiss Institute for Geometry, Dresden University of Technology, Dresden D-01062, Japan 2001Computer Aided Drafting,Design and Manufacturing2001,11,1:0
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