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| 1 | Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis显示文摘AIM: To investigate the antif ibrotic effects of peginterferon- alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological f ibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of f ibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.CONCLUSION: Peginterferon-alpha 2b exerts anti- f ibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antif ibrotic strategy. | Ilker Tasci Mehmet Refik Mas Sevil Atalay Vural Salih Deveci Bilgin Comert Gunay Alcigir Nuket Mas Cemal Akay Mithat Bozdayi Cihan Yurdaydin Hakan Bozkaya Ozden Uzunalimoglu Ahmet Turan Isik Harun M Said | 2007 | World Journal of Gastroenterology2007，13，23： | 7 |
| 2 | Self cleaning photoactive TiO2 coatings on SLS glasses by sol-gel dip coating显示文摘 | Sam E D Urgen M Tepehan F Z Gunay V | 2004 | Key Engineering Materials2004，，： | 1 |
| 3 | Identification of genom-ic heterogeneity among lactococcus lactis strains by plasmid profi-ling ,PFGE and 16s rDNA sequence analysis显示文摘 | Gunay - Esiyok 0 Akcelik N Akcelik M | 2014 | Pol J Microbiol2014，63，2： | 1 |
| 4 | Investigation of the effect of rake angle on main cutting forces 显示文摘 | Gunay M Aslan E Korkut I | 2004 | International Journal of Machine Tools and Manufacture2004，44，9： | 1 |
| 5 | Management of pa- tients with recurrent hepatocellular carcinoma following living donor liver transplantation: A single center experi- ence显示文摘 | Gunay Y Guler N Akyyildiz M | 2014 | Gulf J Oncolog2014，1，15： | 1 |
| 6 | Simple Polyol Route to Synthesize Heptanoic Acid Coated Magnetite ( Fes 04 ) Nanopatticles 显示文摘 | Gunay M Kavas H Baykal A | 2013 | Materials Research Bulletin2013，48，3： | 1 |
| 7 | Primary lipoma of the adrenal gland显示文摘 | Gunay L M Bas K K Uygur M C | 2011 | Am Surg2011，77，9： | 1 |
| 8 | Identification of EMG signals using discriminant analysis and SVM classifier 显示文摘 | ALKAN A GUNAY M | 2012 | Expert Systems with Applications2012，9，1： | 1 |
| 9 | Hsp70, hsCRP and oxidative stress in patients with acute coronary syn- dromes显示文摘 | Amanvermez R Acar E Gunay M | 2012 | Basic Med Sci2012，12，2： | 1 |
| 10 | Preoperative evaluation of hilar vessel anatomy with 3D computerized tomography in living kidney donors显示文摘 | Tombul ST Aki FT Gunay M | 2008 | Transplant Proc2008，40，1： | 1 |
| 11 | Environmental protection of geothermal waters and travertines at pamukkale, Turkey显示文摘 | S Simsek G Gunay H Elhatip M Ekmekci | 2000 | Geothermics2000，2945，： | 1 |
| 12 | Tubeless mini percutaneous neph- rolithotomy in infants and preschool children: A preliminary report 显示文摘 | Bilen CY Gunay M Ozden E etal | 2010 | J Urol2010，184，6： | 1 |
| 13 | and Testing 显示文摘 | Frankfurter G M and Gunay E Management Buyouts and Anticipated Gains to Shareholders -Theory | 1993 | International Review of Financial Analysis1993，2，： | 1 |
| 14 | Molecular defects that affect platelet dense granules显示文摘 | Gunay -Aygun M Huizing M Gahl WA | 2004 | Semin Thromb Hemost2004，30，5： | 1 |
| 15 | The levels of some antioxdant vitamins,glutathione peroxidase and lipoperoxidase during the anaesthesia of dogs显示文摘 | Naziroglu M Gunay C | 1999 | Cell Biochem Funct1999，17，3： | 1 |
| 16 | Tubeless mini percutaneous nephrolithotomy in infants and preschool children:apreliminary report显示文摘 | Bilen C Y Gunay M Ozden E | 2010 | J Urol2010，184，6： | 1 |
| 17 | Preoperative evaluation of hilar vessel anatomy with 3-D computerized tomography in liv- ing kidney donors 显示文摘 | Tombul ST Aki FT Gunay M | 2008 | Transplant Proc2008，40，： | 1 |
| 18 | Preoperative evaluation of hilar vessel anatomy with 3D computerized tomography in living kidney donors显示文摘 | Tombul S T Aki F T Gunay M | 2008 | Transplant Proc2008，40，1： | 1 |
| 19 | Effects of static magnetic field on specific adenosine-5'-triphosphatase activities and bioelectrical and biomechanical properties in the rat diaphrag muscle显示文摘 | ITEGGIN M GUNAY I LOGOLU G | 1995 | Bioelectromagnetics1995，16，3： | 1 |
| 20 | Reliability and reproduc- ibility of classifieations for distal radius fractures 显示文摘 | Kueuk L Kumbaraci M Gunay H | 2013 | Acta Orthop Traumatol Turc2013，47，3： | 1 |
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