| 1 | Influence of the concentration of dietary digestible calcium on growth performance,bone mineralization, plasma calcium, and abundance of genes involved in intestinal absorption of calcium in pigs from 11 to 22 kg fed diets with different concentrations of显示文摘Background: A 21-day experiment was conducted to test the hypothesis that Ca requirements to maximize growth performance expressed as the standardized total tract digestible(STTD) Ca to STTD P ratio is less than 1.40:1. The second hypothesis was that increasing dietary Ca increases plasma Ca concentration and downregulates abundance of genes related to Ca absorption(TRPV6, S100 G, and ATP2 B1) in the duodenum, and tight junction proteins(OCLN, CLDN1, and ZO1) in the duodenum and ileum.Methods: Twenty corn-soybean meal diets were formulated using a 4 × 5 factorial design with diets containing 0.16%, 0.33%, 0.42%, or 0.50% STTD P, and 0.14%, 0.29%, 0.44%, 0.59%, or 0.74% STTD Ca. Six hundred and forty pigs(initial weight: 11.1 ± 1.4 kg) were allotted to 20 diets and 5 blocks in a randomized complete block design. On day21, weights of pigs and feed left in feeders were recorded and blood, duodenal tissue, ileal mucosa, and the right femur were collected from 1 pig per pen. Abundance of m RNA was determined in duodenal and ileal tissue via quantitative RT-PCR. Data were analyzed using a response surface model.Results: The predicted maximum ADG(614 g), G:F(0.65), and bone ash(11.68 g) was obtained at STTD Ca:STTD P ratios of 1.39:1, 1.25:1, and 1.66:1, respectively, when STTD P was provided at the requirement(0.33%). If dietary STTD P was below the requirement, increasing dietary Ca resulted in reduced(P < 0.05) ADG and G:F. However, if dietary STTD P was above the requirement, negative effects(P < 0.05) on ADG and G:F of increasing STTD Ca were observed only if dietary STTD Ca exceeded 0.6%. Plasma Ca concentration was positively affected by STTD Ca over the range studied(quadratic, P < 0.01) and negatively affected by increasing STTD P(linear, P < 0.01). There was a linear negative effect(P < 0.05) of STTD Ca on the abundance of S100 G, TRPV6, OCLN, and ZO1 in duodenum, and CLDN and ZO1 in ileum.Conclusions: The STTD Ca:STTD P ratio needed to maximize growth performance of 11-to 25-kg pigs is less than1.40:1, if P is at the estimated requirement. Increasing dietary Ca reduces transcellular absorption of Ca and increases paracellular absorption of Ca. | L.Vanessa Lagos Su A.Lee Guillermo Fondevila Carrie L.Walk Michael R.Murphy Juan J.Loor Hans H.Stein | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 2 |
| 4 | Assessing the effectiveness of quarantine measures during the COVID-19 pandemic in Chile using Bayesian structural time series models显示文摘Background:With the emergence of the COVID-19 pandemic,all existing health protocols were tested under the worst health crisis humanity has experienced since the Black Death in the 14th century.Countries in Latin America have been the epicenter of the COVID-19 pandemic,with more than 1.5 million people killed.Worldwide health measures have included quarantines,border closures,social distancing,and mask use,among others.In particular,Chile implemented total or partial quarantine measures depending on the number of infections in each region of the country.Therefore,it is necessary to study the effectiveness of these quarantines in relation to the public health measures implemented by government entities at the national level.Objective:The main objective of this study is to analyze the effectiveness of national-and region-level quarantines in Chile during the pandemic based on information published by the Chilean Ministry of Health,and answers to the following question are sought:Were quarantine measures in Chile effective during the COVID-19 pandemic?Methods:The causal effect between the rates of COVID-19 infections and the population rates in Phase 1 and Phase 2 quarantines in the period from March 2020 to March 2021 in different regions of Chile were evaluated using intervention analyses obtained through Bayesian structural time series models.In addition,the Kendall correlation coefficient obtained through the copula approach was used to evaluate the comovement between these rates.Results:In 75%of the Chilean regions under study(12 regions out of a total of 16),an effective Phase 1 quarantine,which was implemented to control and reduce the number of cases of COVID-19 infection,was observed.The main regions that experienced a decrease in cases were those located in the north and center of Chile.Regarding Phase 2,the COVID-19 pandemic was effectively managed in 31%(5 out of 16)of the regions.In the southcentral and extreme southern regions of Chile,the effectiveness of these phases was null.Conclusion:The findings indicate that in the northern and central regions of Chile,the Phase 1 quarantine application period was an effective strategy to prevent an increase in COVID-19 infections.The same observation was made with respect to Phase 2,which was effective in five regions of northern Chile;in the rest of the regions,the effectiveness of these phases was weak or null. | Claudia Barría-Sandoval Guillermo Ferreira Bernardo Lagos Carola Montecino Bacigalupo | 2022 | Infectious Disease Modelling2022，7，4： | 0 |
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