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| 1 | Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts显示文摘The accumulation and aggregation of alpha-synuclein(α-syn)in several tissue including the brain is a major pathological hallmark in Parkinson’s disease(PD).In this study,we show that α-syn can be taken up by primary human cortical neurons,astrocytes and skin-derived fibroblasts in vitro.Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function,leading to cellular degeneration and cell death,provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. | Nady Braidy Wei-Ping Gai Ying Hua Xu Perminder Sachdev Gilles J Guillemin Xing-Mai Jiang J William O Ballard Martin P Horan Zhi Ming Fang Beng H Chong Daniel Kam Yin Chan | 2013 | Translational Neurodegeneration2013，2，1： | 4 |
| 2 | Pancreatite chronique calcifiante chez un tuberculeux renal:pancreatojejunostomie seion une technique originale显示文摘 | Guillemin P Bessot M | 1957 | Mem Acad Chir Paris1957，83，3： | 1 |
| 3 | Cross-culture adaptation of health-related quality of life measures: literature review and proposed guidelines 显示文摘 | Guillemin F Bombardier C Beaton D | 1993 | J Clin Epidemiol1993，46，12： | 1 |
| 4 | How to assess musculoskeletal conditions assessment of disease activity显示文摘 | Guillemin F | 2003 | Best Pract Res Clin Rheumatol2003，17，3： | 1 |
| 5 | Guidelines for the process of cross-cultural adaptation of self-report measures 显示文摘 | Beaton DE Bombardier C Guillemin F | 2000 | Spine ( Phila Pa 1976 )2000，25，： | 1 |
| 6 | Segregation analysiaandvariance components analysis of bone mineral density in healthy families显示文摘 | Morrison R Jouanny P Guillemin F | 1995 | J Bone Miner Res1995，10，： | 1 |
| 7 | Microglia macrophages,perivascularmacrophages,and pericytes:a review of function and identification显示文摘 | Guillemin GJ Brew BJ | 2004 | J Leukoc Biol2004，75，3： | 1 |
| 8 | Somatostatin:Physiological and clinical significance显示文摘 | Guillemin R Gerich JE | | 0，，： | 1 |
| 9 | Guidelines for the process of cross - cultural adaptation of self - report measures 显示文摘 | Beaton DE Bombardier C Guillemin F | 2000 | Spine2000，25，24： | 1 |
| 10 | Fatigue in multiple sclerosis is related to disability, depression and quality of life显示文摘 | Pittion-Vouyovitch S Debouverie M Guillemin F | 2006 | J Neurol Sci2006，243，12： | 1 |
| 11 | Gmde-lines for the process of cross - cultural adaptation of self -report measures显示文摘 | Beaton D E Bcnnkardier C Guillemin F | 2000 | Spine2000，25，24： | 1 |
| 12 | Chronic calcifying pancreatitis in renal tuberculosis: pancreatojejunostomy using an original technic显示文摘 | Guillemin P Bessot M | 1957 | Mere Acad Chir (Paris)1957，83，2728： | 1 |
| 13 | Anthrax 显示文摘 | Dixon TC Meselson M Guillemin J | 1999 | N Engl J Med1999，341，11： | 1 |
| 14 | Guidelines for the process of cross-cultural adaptation of self-report measures 显示文摘 | Beaton DE Bombardier C Guillemin F | 2000 | Spine (Phila Pa 1976)2000，25，24： | 1 |
| 15 | Guidelines for the process of cross-cultural adaptation of self-report measures显示文摘 | Beaton DE Bombardier C Guillemin F Ferraz MB | 2000 | Spine (Phila Pa 1976)2000，25，24： | 1 |
| 16 | Prevalence of impairments, disabilities, handicaps and quality of life in the general population: a review of recent literature 显示文摘 | Barbotte E Guillemin F Chau N | 2001 | Bull World Health Organ2001，79，11： | 1 |
| 17 | Humoral hypothalamic control of anterior pituitary:a study with combined tissue cultures显示文摘 | Guillemin R Rosenberg B | | 0，，05： | 1 |
| 18 | Radiograpraphic scoring methods as outcome measures in rheumatoid arthritis: properties and advan- tages显示文摘 | Boini S Guillemin F | 2001 | Ann Rheum Dis2001，60，9： | 1 |
| 19 | Bias and preci- sion in visual analogue scales: a randomized controlled trial 显示文摘 | Paul-Dauphin A Guillemin F Virion J M | 1999 | Am J Epidemiology1999，150，10： | 1 |
| 20 | Multivariate analysis of predictors of cerebral vasospasm occurrence after aneurysmal subarachnoid hemorrhage 显示文摘 | Charpentier C Audibert G Guillemin F | 1999 | Stroke1999，30，7： | 1 |
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