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| 1 | Path planning for mobile robot using self-adaptive learning particle swarm optimization显示文摘As a challenging optimization problem, path planning for mobile robot refers to searching an optimal or near-optimal path under different types of constrains in complex environments. In this paper, a self-adaptive learning particle swarm optimization(SLPSO) with different learning strategies is proposed to address this problem. First, we transform the path planning problem into a minimisation multi-objective optimization problem and formulate the objective function by considering three objectives: path length, collision risk degree and smoothness. Then, a novel self-adaptive learning mechanism is developed to adaptively select the most suitable search strategies at different stages of the optimization process, which can improve the search ability of particle swarm optimization(PSO). Moreover, in order to enhance the feasibility of the generated paths, we further apply the new bound violation handling schemes to restrict the velocity and position of each particle. Finally, experiments respectively with a simulated robot and a real robot are conducted and the results demonstrate the feasibility and effectiveness of SLPSO in solving mobile robot path planning problem. | Guangsheng LI Wusheng CHOU | 2018 | Science China(Information Sciences)2018，61，5： | 46 |
| 2 | Response of soil heat-water processes to vegetation cover on the typical permafrost and seasonally frozen soil in the headwaters of the Yangtze and Yellow Rivers显示文摘The response of soil temperature and moisture to vegetative cover in the active layer of permafrost and seasonally frozen soil were assessed and compared. Soil temperature and moisture, under a range of vegetation covers (92%, 65% and 30%) in the permafrost and vegetation covers (95%, 70%―80%, 40%―50% and 10%) in the seasonally frozen soil, were measured on a daily basis. A decline in vege-tation cover led to a decrease in the integral of freezing depth of active permafrost layer, but an increase in seasonally frozen soil. The maximum invasion depth and duration of the negative isotherm during the frozen period and of the positive isotherm during the non-frozen period clearly increased when vegetation cover declined. With a reduction of vegetation cover, the soil moisture in the active layer of the permafrost decreased for depths of 0.20―0.60 m, but increased for depths of 0.60―0.80 m, while for seasonally frozen soil, soil moisture of the entire profile (0.10―1.20 m) increased. Variation in vegetation cover alters soil heat-water processes, but the response to it is different between permafrost and seasonally frozen soil. | HU HongChang WANG GenXu WANG YiBo LIU GuangSheng LI TaiBing REN DongXing | 2009 | Chinese Science Bulletin2009，54，7： | 18 |
| 3 | Transmutation of ancient settlements and environmental changes between 6000-2000 aBP in the Chaohu Lake Basin, East China显示文摘Based on the temporal-spatial distribution features of ancient settlement sites from the middle and late Neolithic Age to the Han dynasty in the Chaohu Lake Basin of Anhui Province,East China,using the methods of GIS combined with the reconstructed paleoenvironment by the records of lake sediment since Holocene,the transmutation of ancient settlements with response to environmental changes in this area has been discussed.Studies show that the main feature of transmutation of ancient settlements from the middle and late Neolithic Age to the Han Dynasty was that the distribution of settlements in this area changed from high altitudes to low ones and kept approaching the Chaohu Lake with the passage of time.These could be the response to the climate change from warm-moist to a relatively warm-dry condition during the middle Holocene,leading to the lake level fluctuations.The large area of exposed land provided enough space for human activities.These indicate that the above changes in geomorphologic evolution and hydrology influenced by climate conditions affected the transmutation of ancient settlements greatly.The distribution pattern of settlement sites was that the number of sites in the west was more than in the east.This pattern may be related to the geomorphologic conditions such as frequent channel shifting of the Yangtze River as well as flood disasters during the Holocene optimum.Therefore,climate change was the inducement of the transmutation of ancient settlements in the Chaohu Lake Basin,which exerted great influence on the distribution,expansion and development of the ancient settlements. | WU Li WANG Xinyuan ZHOU Kunshu MO Duowen ZHU Cheng GAO Chao ZHANG Guangsheng LI Lan LIU Li HAN Weiguang | 2010 | Journal of Geographical Sciences2010，20，5： | 16 |
| 4 | Environmental changes during early-middle Holocene from the sediment record of the Chaohu Lake,Anhui Province显示文摘A typical lake sediment core is obtained from the Chaohu Lake in the lower reaches of the Yangtze River,Anhui Province,China.The timing scale is constrained by AMS 14 C dating method.Climate proxies such as pollen and grain size in the core are analyzed to reconstruct the environment changes at this site approximately between 9870 and 2170 cal.a BP.The results indicate that at the research area, the climate in the early-middle Holocene had evolved through 3 stages.From 9870 to 6040 cal.a BP, proxy records show a warm and dry climate with low water levels after the late-glacial period.During this stage,cool and dry events occurred at about 8910 and 6060-6030 cal.a BP.Then,between 6040 and 4860 cal.a BP,the climate was humid and vegetation was more flourishing in the Chaohu Lake Valley.The Holocene Optimum occurred at 5840-5500 cal.a BP in the Chaohu Lake,showing the best condition of water and heat.Elm Decline occurred at the period of 5380-4930 cal.a BP.Since 4860 cal.a BP,the climate was warm and dry through 2170 cal.a BP as shown in both pollen spectrum and grain-size histories.Two obvious dry events occurred in 3760 and 2170 cal.a BP,respectively.At 2170 cal.a BP,the water level of the Chaohu Lake reached the lowest as the lakebed possibly exposed. Such lake sediment observations are consistent with the historical records in this area. | XinYuan Wang GuangSheng Zhang Li Wu XiHui Zhang EnLou Zhang XiaYun Xiao QingFeng Jiang | 2008 | Chinese Science Bulletin2008，53，S1： | 15 |
| 5 | Spore-pollen-climate factor transfer function and paleoenvironment reconstruction in Dajiuhu,Shennongjia,Central China显示文摘The identified results of 121 surface sediment spore-pollen samples in Shennongjia and meteorological data base of 30 years(January,1971―December,2000)of 7 meteorological stations around Dajiuhu, Shennongjia are used in this study.Selecting 55 species of common spore-pollen with the method of space fitting and stepwise regression we construct the pollen climate factor transfer function of annual mean tem- perature:T=7.649-2.33097X Abies -0.10873X Betula -0.17352X Compositae -0.13176X Cruciferae +0.13356XEuphorbiaceae -0.83069X Campanulaceae +1.96494XPyrrosia+0.38411XPteris+2.77741XSelaginella+0.04439XMonolites.We had reconstructed annual mean temperature series by use of the sporo-pollen samples concentra-tion percentage in peat section with 297 cm thickness in Dajiuhu since 15.753 kaBP.The temperature series reflect well the character of climatic change since the late glacial,which indicates extreme cold climate event of the Oldest Dryas,the Older Dryas,the Younger Dryas and the 8.2 kaBP,the same to the climate fluctuations of Bolling Warm Period and Allerod Warm Period,and the character of temperature change fluctuating frequently at the transition age from the late glacial to the Holocene.The reconstructed temperature also indicate Holocene Optimum,late Holocene warm-dry climate,and the character of climatic change in Dajiuhu in the last 1 ka.The conclusion is that the sporo-pollen samples have important climatic significance to surface sediment and the section of Dajiuhu,Shennongjia and important reference value to studying climatic change during the last glaciation by the temperature transfer function and reconstructed temperature series. | ZHU Cheng CHEN Xing ZHANG GuangSheng MA ChunMei ZHU Qing LI ZhongXuan XU WeiFeng | 2008 | Chinese Science Bulletin2008，53，S1： | 15 |
| 6 | Laboratory simulation on acoustic well-logging with phased array transmitter显示文摘Two small scale acoustic phased arrays with 4 elements have been designed and assembled in the laboratory. Experiments have been carried out with them. It is found that both directivity and radiation lobe width of the phased array can be regulated by changing the time delay between the input signals on neighboring elements. Results measured are in good agreement with those calculated. By using the phased array as an acoustic transmitter and hydrophone as a receiver, small scale acoustic well-logging simulations have been carried out both on an aluminum model well and on a concrete one. Experimental results show that, by increasing the time delay of the input signals on neighboring elements, the steered radiation angle of the phased array becomes larger and larger, and generation conditions of the refracted compressional wave and the refracted shear wave are reached successively, and the refracted compressional wave, the refracted shear wave and the Stoneley wave axe strengthened, respectively. Therefore, by choosing element spacing of a phased array and acoustic wave frequency appropriately, the main radiation lobe of the phased array can be widened to cover the first critical angle of all kinds of formations, which makes it possible to apply phased array acoustic well-logging in any formation continuously without regulating directivity of the phased array. | QIAO Wenxiao CHEN Xuelian DU Guangsheng FANG Jun LI Gang(Faculty of Natural Resources and Information Technology, University of Petroleum Beijing 102249) | 2003 | Chinese Journal of Acoustics2003，22，4： | 14 |
| 7 | Comparison of Postoperative Pain Following Laser-assisted Subepithelial Keratectomy and Transepithelial Photorefractive Keratectomy:a Prospective,Random Paired Bilateral Eye Study显示文摘Purpose:To compare postoperative pain following laser-assisted subepithelial keratectomy(LASEK) and transepithelial photorefractive keratectomy(T-PRK, two-step surgery) and alleviate postoperative subjective pain.Methods:.Thirty patients(60 eyes) with myopia or myopic astigmatism were consecutively recruited into this prospective,randomized paired study..Patients underwent LASEK in one eye,and T-PRK in the other. The degree of pain was rated on a scale of 0-10 on postoperative days 1,2 and 3..Uncorrected visual acuity(UCVA) and subepithelial corneal haze were assessed at postoperative 1 and 3 months.Results:.The pain was relieved on the 4th postoperative day in all patients,.healing of corneal epithelium was observed at4-5 days after surgery and contact lenses were removed promptly.At postoperative 1 day,.the mean subjective pain score in the LASEK group was 3.2±1.88 and 4.43±1.61 in TPRK group(P=0.008).No significant difference was found between two groups on postoperative 2 and 3 days. At postoperative 3 months, the percentage of UCVA ≥0.8 in the LASEK group was 100% and 96.7% in the T-PRK group.(P =0.24),93.3% of patients in the LASEK with UCVA ≥1.0 and 90%in the T-PRK group(P=0.64). In the LASEK group, the value of corneal haze was 0.26 ±0.21 and 0.27 ±0.25 in the T-PRK group(P=0.877).Conclusion:.Good visual acuity was obtained in both groups at postoperative 3 months. Compared with those in the T-PRKgroup, patients undergoing had less discomfort in the LASEK group, which may be associated with corneal epithelial activity. The changing curve of subjective pain in the T-PRK group was relatively flat and stable at postoperative 3 days. | Dongmei Wang Guangsheng Chen Liusong Tang Qiaoling Li | 2014 | Eye Science2014，29，3： | 14 |
| 8 | A Mitochondria-Targeted PPR Protein Restores pol Cytoplasmic Male Sterility by Reducing orF224 Transcript Levels in Oilseed Rape显示文摘 | Liu, Zhi Yang, Zonghui Wang, Xiang Li, Kaidi An, Hong Liu, Jie Yang, Guangsheng Fu, Tingdong Yi, Bin Hong, Dengfeng | 2016 | Molecular Plant2016，9，7： | 14 |
| 9 | Toward a general evaluation model for soil respiration (GEMSR)显示文摘Soil respiration is an important component of terrestrial carbon budget. Its accurate evaluation is es- sential to the study of terrestrial carbon source/sink. Studies on soil respiration at present mostly focus on the temporal variations and the controlling factors of soil respiration, but its spatial variations and controlling factors draw less attention. Moreover, the evaluation models for soil respiration at present include only the effects of water and heat factors, while the biological and soil factors controlling soil respiration and their interactions with water and heat factors have not been considered yet. These models are not able to accurately evaluate soil respiration in different vegetation/terrestrial ecosystems at different temporal and spatial scales. Thus, a general evaluation model for soil respiration (GEMSR) including the interacting meteorological (water and heat factors), soil nutrient and biological factors is suggested in this paper, and the basic procedure developing GEMSR and the research tasks of soil respiration in the future are also discussed. | ZHOU GuangSheng, JIA BingRui, HAN GuangXuan & ZHOU Li Key Laboratory of Vegetation and Environmental Change, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China | 2008 | Science China(Life Sciences)2008，51，3： | 12 |
| 10 | Stability analyses of vertically exposed cemented backfill:A revisit to Mitchell's physical model tests显示文摘Mitchell's solution is commonly used to determine the required strength of vertically exposed cemented backfill in mines. Developed for drained backfill, Mitchell model assumed a zero friction angle for the backfill. Physical model tests were performed. Good agreements were obtained between the required strengths predicted by the analytical solution and experimental results. However, it is well-known that zero friction angle can only be possible in terms of total stresses when geomaterials are submitted to unconsolidated and undrained conditions. A revisit to Mitchell's physical model tests reveals that both the laboratory tests performed for obtaining the shear strength parameters of the cemented backfill and the box stability tests were conducted under a condition close to undrained condition. This explains well the good agreement between Mitchell's solution and experimental results. Good agreements are equally obtained between Mitchell's experimental results and FLAC3 D numerical modeling of shortterm stability analyses of exposed cemented backfill. | Liu Guangsheng Li Li Yang Xiaocong Guo Lijie | 2016 | International Journal of Mining Science and Technology2016，26，6： | 11 |
| 11 | Experimental investigation on aero-heating of rudder shaft within laminar/turbulent hypersonic boundary layers显示文摘The aero-heating of the rudder shaft region of a hypersonic vehicle is very harsh, as the peak heat flux in this region can be even higher than that at the stagnation point. Therefore, studying the aero-heating of the rudder shaft is of great significance for designing the thermal protection system of the hypersonic vehicle. In the wind tunnel test of the aero-heating effect, we find that with the increase of the angle of attack of the lifting body model, the increasement of the heat flux of the rudder shaft is larger under laminar flow conditions than that under turbulent flow conditions. To understand this, we design a wind tunnel experiment to study the effect of laminar/turbulent hypersonic boundary layers on the heat flux of the rudder shaft under the same wind tunnel freestream conditions. The experiment is carried out in the ?2 m shock tunnel(FD-14 A) affiliated to the China Aerodynamics Research and Development Center(CARDC). The laminar boundary layer on the model is triggered to a turbulent one by using vortex generators, which are 2 mm-high diamonds. The aero-heating of the rudder shaft(with the rudder) and the protuberance(without the rudder) are studied in both hypersonic laminar and turbulent boundary layers under the same freestream condition. The nominal Mach numbers are 10 and 12, and the unit Reynolds numbers are2.4 × 10~6 m^(-1) and 2.1 × 10~6 m-1. The angle of attack of the model is 20°, and the deflection angle of the rudder and the protuberance is 10°. The heat flux on the model surface is measured by thin film heat flux sensors, and the heat flux distribution along the center line of the lifting body model suggests that forced transition is achieved in the upstream of the rudder. The test results of the rudder shaft and the protuberance show that the heat flux of the rudder shaft is lower in the turbulent flow than that in the laminar flow, but the heat flux of the protuberance is the other way around,i.e., lower in the laminar flow than in the turbulent flow. The wind tunnel test results is also validated by numerical simulations. Our analysis suggests that this phenomenon is due to the difference of boundary layer velocities caused by different thickness of boundary layer between laminar and turbulent flows, as well as the restricted flow within the rudder gap. When the turbulent boundary layer is more than three times thicker than that of the laminar boundary layer, the heat flux of the rudder shaft under the laminar flow condition is higher than that under the turbulent flow condition. Discovery of this phenomenon has great importance for guiding the design of the thermal protection system for the rudder shaft of hypersonic vehicles. | Qiang LI Liang NIE Kouli ZHANG Yu LI Suyu CHEN Guangsheng ZHU | 2019 | Chinese Journal of Aeronautics2019，32，5： | 11 |
| 12 | Forecast of Flood in Chaohu Lake Basin of China Based on Grey-Markov Theory显示文摘Flood is one kind of unexpected and the most common natural disasters, which is affected by many factors and has complex mechanism. At home and abroad, there is still no mature theory and method used for the long-term forecast of natural precipitation at present. In the present paper the disadvantages of grey GM (1, 1) and Markov chain are ana- lyzed, and Grey-Markov forecast theory about flood is put forward and then the modifying model is developed by making prediction of Chaohu Lake basin. Hydrological law was conducted based on the theoretical forecasts by grey system GM (1, 1) forecast model with improved Markov chain. The above method contained Stat-analysis, embodying scientific approach, precise forecast and its reliable results. | LI Xiang WANG Xinyuan SHAO Wei XIA Linyi ZHANG Guangsheng TIAN Bing LI Wenda PENG Peng | 2007 | Chinese Geographical Science2007，17，1： | 10 |
| 13 | Textural Evolution of AZ31B Magnesium Alloy Sheets Undergoing Repeated Unidirectional Bending at Room Temperature显示文摘In this paper, repeated unidirectional bending (RUB), was applied to improve the texture of AZ31B magnesium alloy sheets so as to enhance their stamping properties. The samples undergoing RUB were annealed at different temperatures. The mechanical properties, formability, textural components and microstructure of the samples before and after RUB were characterized and compared. It was found that the basal textural component was reduced dramatically by RUB, and that (12ˉ12) and (12ˉ11) textural components appeared. Annealing has a great effect on the mechanical properties of samples undergoing RUB. The plasticity and stamping formability of samples were greatly improved by RUB and annealing at 260?C for 1 h, and elongation to fracture and Erichsen value were increased to 38% and 67%, respectively. | Guangsheng Huang Wei Xu Guangjie Huang Hongcheng Li Bo Song | 2009 | Journal of Materials Science & Technology2009，25，3： | 9 |
| 14 | Spatiotemporal dynamic simulation of grassland carbon storage in China显示文摘Based on the Terrestrial Ecosystem Model(TEM 5.0), together with the data of climate(temperature, precipitation and solar radiation) and environment(grassland vegetation types, soil texture, altitude, longitude and latitude, and atmospheric CO2 concentration data), the spatiotemporal variations of carbon storage and density, and their controlling factors were discussed in this paper. The results indicated that:(1) the total carbon storage of China's grasslands with a total area of 394.93×104 km2 was 59.47 Pg C. Among them, there were 3.15 Pg C in vegetation and 56.32 Pg C in soil carbon. China's grasslands covering 7.0–11.3% of the total world's grassland area had 1.3–11.3% of the vegetation carbon and 9.7–22.5% of the soil carbon in the world grasslands. The total carbon storage increased from 59.13 to 60.16 Pg C during 1961–2013 with an increasing rate of 19.4 Tg C yr^(-1).(2) The grasslands in the Qinghai-Tibetan Plateau contributed most to the total carbon storage during 1961–2013, accounting for 63.2% of the total grassland carbon storage, followed by Xinjiang grasslands(15.8%) and Inner Mongolia grasslands(11.1%).(3) The vegetation carbon storage showed an increasing trend, with the average annual growth rate of 9.62 Tg C yr^(-1) during 1961–2013, and temperature was the main determinant factor, explaining approximately 85% of its variation. The vegetation carbon storage showed an increasing trend in most grassland regions, however, a decreasing trend in the central grassland in the southern China, the western and central parts of the Inner Mongolian grasslands as well as some parts on the Qinghai-Tibetan Plateau. The soil carbon storage showed a significantly increasing trend with a rate of 7.96 Tg C yr^(-1), which resulted from the interaction of more precipitation and low temperature in the 1980 s and 1990 s. Among them, precipitation was the main determinant factor of increasing soil carbon increases of China's grasslands. | ZHANG Li ZHOU GuangSheng JI YuHe BAI YongFei | 2016 | Science China Earth Sciences2016，59，10： | 8 |
| 15 | Variation of net primary productivity and its drivers in China’s forests during 2000-2018显示文摘Background:Net primary productivity(NPP)in forests plays an important role in the global carbon cycle.However,it is not well known about the increase rate of China’s forest NPP,and there are different opinions about the key factors controlling the variability of forest NPP.Methods:This paper established a statistics-based multiple regression model to estimate forest NPP,using the observed NPP,meteorological and remote sensing data in five major forest ecosystems.The fluctuation values of NPP and environment variables were extracted to identify the key variables influencing the variation of forest NPP by correlation analysis.Results:The long-term trends and annual fluctuations of forest NPP between 2000 and 2018 were examined.The results showed a significant increase in forest NPP for all five forest ecosystems,with an average rise of 5.2 gC·m-2·year-1 over China.Over 90%of the forest area had an increasing NPP range of 0-161 gC·m-2·year-1.Forest NPP had an interannual fluctuation of 50-269 gC.m-2·year-1 for the five major forest ecosystems.The evergreen broadleaf forest had the largest fluctuation.The variability in forest NPP was caused mainly by variations in precipitation,then by temperature fluctuations.Conclusions:All five forest ecosystems in China exhibited a significant increasing NPP along with annual fluctuations evidently during 2000-2018.The variations in China’s forest NPP were controlled mainly by changes in precipitation. | Yuhe Ji Guangsheng Zhou Tianxiang Luo Yakir Dan Li Zhou Xiaomin Lv | 2020 | Forest Ecosystems2020，7，2： | 8 |
| 16 | A detailed investigation of low latitude tweek atmospherics observed by the WHU ELF/VLF receiver:Ⅰ. Automatic detection and analysis method显示文摘As a dispersive wave mode produced by lightning strokes, tweek atmospherics provide important hints of lower ionospheric(i.e., D-region) electron density. Based on data accumulation from the WHU ELF/VLF receiver system, we develop an automatic detection module in terms of the maximum-entropy-spectral-estimation(MESE) method to identify unambiguous instances of low latitude tweeks.We justify the feasibility of our procedure through a detailed analysis of the data observed at the Suizhou Station(31.57°N, 113.32°E) on17 February 2016. A total of 3961 tweeks were registered by visual inspection;the automatic detection method captured 4342 tweeks, of which 3361 were correct ones, producing a correctness percentage of 77.4%(= 3361/4342) and a false alarm rate of 22.6%(= 981/4342).A Short-Time Fourier Transformation(STFT) was also applied to trace the power spectral profiles of identified tweeks and to evaluate the tweek propagation distance. It is found that the fitting accuracy of the frequency–time curve and the relative difference of propagation distance between the two methods through the slope and through the intercept can be used to further improve the accuracy of automatic tweek identification. We suggest that our automatic tweek detection and analysis method therefore supplies a valuable means to investigate features of low latitude tweek atmospherics and associated ionospheric parameters comprehensively. | RuoXian Zhou XuDong Gu KeXin Yang GuangSheng Li BinBin Ni Juan Yi Long Chen FuTai Zhao ZhengYu Zhao Qi Wang LiQing Zhou | 2020 | Earth and Planetary Physics2020，4，2： | 7 |
| 17 | Influence of heating rate on reactivity and surface chemistry of chars derived from pyrolysis of two Chinese low rank coals显示文摘A series of char samples were derived from pyrolysis of two typical low-rank coals in China(Shengli lignite and Shenmu bituminous coal) at low, medium and fast heating rates, respectively, to the same pyrolysis temperature 750 °C. Then these chars were characterized by means of thermogravimetric analysis and Fourier transform infrared spectrometer with the aim to investigate the influence of heating rate in pyrolysis process on gasification reactivity and surface chemistry of them. Besides, a homogeneous model was used to quantitatively analyze the activation energy of gasification reaction. The results reveal that Shengli lignite and its derived chars behave higher gasification reactivity and have less content of oxygen functional groups than Shenmu coal and chars. Meanwhile, chars derived from Shengli lignite at 50 °C/min and Shenmu coal at 200 °C/min have the greatest gasification reactivity, respectively. The oxygen functional groups in Shengli lignite are easily thermo-decomposed, and they are less affected by the heating rate, while that in Shenmu coal have a significant change with the variation of heating rate.In addition, there is no good correlation between the change of oxygen functional groups and that of the gasification reactivity of the derived chars from pyrolysis at different heating rates. | Liang Dingcheng Xie Qiang Li Guangsheng Cao Junya Zhang Jun | 2018 | International Journal of Mining Science and Technology2018，28，4： | 6 |
| 18 | Structure and Anti-influenza A(H1N1) Virus Activity of Three Polysaccharides from Eucheuma denticulatum显示文摘Three polysaccharides(EW,EH and EA) were prepared from a red alga Eucheuma denticulatum by sequential extraction with cold water,hot water and sodium hydroxide water solution.Their monosaccharide compositions,relative molecular mass and structural characterization were determined by gas chromatography,high performance 1iquid chromatography,fourier transform infrared spectroscopy and nuclear magnetic resonance spectroscopy methods.EW was hybrid ι/κ/ν-carrageenan(70 ι/17κ/13ν-carrabiose),EH was mainly ι-carrageenan,and EA was mainly α-1,4-Glucan(88%) but mixed with small amount of ι-carrageenan(12%).The relative molecular mass of EW,EH and EA was 480,580 and 510 kDa,respectively.The anti-influenza A(H1N1) virus activity of these three polysaccharides was evaluated using the Madin-Darby canine kidney cells model.EW showed good anti-H1N1 virus activity,its IC 50 was 276.5 μg mL-1,and the inhibition rate to H1N1 virus was 52% when its concentration was 250 μg mL-1.The IC 50 of ι-carrageenan EH was 366.4 μg mL-1,whereas EA showed lower anti-H1N1 virus activity(IC 50 >430 μg mL-1).Available data obtained give positive evidence that the hybrid carrageenan EW from Eucheuma denticulatum can be used as potential anti-H1N1 virus inhibitor in future. | YU Guangli LI Miaomiao WANG Wei] LIU Xin ZHAO Xiaoliang LV Youjing LI Guangsheng JIAO Guangling ZHAO Xia | 2012 | Journal of Ocean University of China2012，11，4： | 5 |
| 19 | A new concept and preliminary study of variable hypersonic inlet with fixed geometry based on shockwave control显示文摘The inlet plays a significant role in the hypersonic airbreathing propulsion. A fixed-geometry inlet is troubled by low air-capture ratio and large additional drag while operating below the design Mach number. Whereas a variable-geometry inlet can maximize performance, but adds weight and complexity to the propulsion system. Based on a fluidic shock shape control technique, this paper proposes a new concept of variable hypersonic inlet with fixed geometry, gives the realization scheme, and conducts a preliminary validation. The results show that the control of the external shock system and the effective throat area can be achieved by the self-provided high pressure fluid of the inlet. For an inlet with an operating Mach-number region of 4 to 6, the shock-on-lip condition can be maintained from Mach 5 to Mach 6 with the maximum expense of 1.8% secondary flow ratio, result- ing in 20% extra captured mass flow and 8% less forebody drag at low Mach num- bers compared with conventional fixed-geometry inlets. Thus, the performance enhancement by using the proposed variable inlet can substantially benefit the acceleration process of hypersonic vehicles at low Mach numbers. | TAN HuiJun CHEN Zhi LI GuangSheng | 2007 | Science China(Technological Sciences)2007，50，5： | 5 |
| 20 | Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes:a pilot study显示文摘Mesenchymal stem cells(MSC)have been used in clinical trials for severe diabetes,a chronic disease with high morbidity and mortality.Bone marrow is the traditional source of human MSC,but human term placenta appears to be an alternative and more readily available source.Here,the therapeutic effect of human placenta-derived MSC(PD-MSC)was studied in type 2 diabetes patients with longer duration,islet cell dysfunction,high insulin doses as well as poor glycemic control in order to evaluate the safety,efficacy and feasibility of PD-MSC treatment in type 2 diabetes(T2D).Ten patients with T2D received three intravenous infusions of PDSC,with one month interval of infusion.The total number of PDSC for each patient was(1.22–1.51)×10^(6)/kg,with an average of 1.35×10^(6)/kg.All of the patients were followed up after therapy for at least 3 months.A daily mean dose of insulin used in 10 patients was decreased from 63.7±18.7 to 34.7±13.4 IU(P<0.01),and the C-peptide level was increased from 4.1±3.7 ng/mL to 5.6±3.8 ng/mL(P<0.05)respectively after therapy.In 4 of 10 responders their insulin doses reduced more than 50%after infusion.The mean levels of insulin and C-peptide at each time point in a total of 10 patients was higher after treatment(P<0.05).No fever,chills,liver damage and other side effects were reported.The renal function and cardiac function were improved after infusion.The results obtained from this pilot clinical trial indicate that transplantation of PD-MSC represents a simple,safe and effective therapeutic approach for T2D patients with islet cell dysfunction.Further large-scale,randomized and well-controlled clinical studies will be required to substantiate these observations. | Ranhua JIANG Zhibo HAN Guangsheng ZHUO Xiaodan QU Xue LI Xin WANG Yuankang SHAO Shimin YANG Zhong Chao HAN | 2011 | Frontiers of Medicine2011，5，1： | 5 |
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