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| 1 | Coronary artery calcium score on low-dose computed tomography for lung cancer screening显示文摘AIM: To evaluate the feasibility of coronary artery calcium score(CACS) on low-dose non-gated chest CT(ngCCT).METHODS: Sixty consecutive individuals(30 males; 73 ± 7 years) scheduled for risk stratification by means of unenhanced ECG-triggered cardiac computed to-mography(gCCT) underwent additional unenhanced ngCCT. All CT scans were performed on a 64-slice CT scanner(Somatom Sensation 64 Cardiac, Siemens, Germany). CACS was calculated using conventional methods/scores(Volume, Mass, Agatston) as previ-ously described in literature. The CACS value obtained were compared. The Mayo Clinic classification was used to stratify cardiovascular risk based on Agatston CACS. Differences and correlations between the two methods were compared. A P-value < 0.05 was considered sig-nificant.RESULTS: Mean CACS values were significantly higher for gCCT as compared to ngCCT(Volume: 418 ± 747 vs 332 ± 597; Mass: 89 ± 151 vs 78 ± 141; Agatston: 481 ± 854 vs 428 ± 776; P < 0.05). The correlation between the two values was always very high(Volume: r = 0.95; Mass: r = 0.97; Agatston: r = 0.98). Of the 6 patients with 0 Agatston score on gCCT, 2(33%) showed an Agatston score > 0 in the ngCCT. Of the 3 patients with 1-10 Agatston score on gCCT, 1(33%) showed an Agatston score of 0 in the ngCCT. Overall, 23(38%) patients were reclassified in a different car-diovascular risk category, mostly(18/23; 78%) shifting to a lower risk in the ngCCT. The estimated radiation dose was significantly higher for gCCT(DLP 115.8 ± 50.7 vs 83.8 ± 16.3; Effective dose 1.6 ± 0.7 mSv vs 1.2 ± 0.2 mSv; P < 0.01).CONCLUSION: CACS assessment is feasible on ngCCT; the variability of CACS values and the associated re-stratification of patients in cardiovascular risk groups should be taken into account. | Teresa Arcadi Erica Maffei Nicola Sverzellati Cesare Mantini Andrea I Guaricci Carlo Tedeschi Chiara Martini Ludovico La Grutta Filippo Cademartiri | 2014 | World Journal of Radiology2014，6，6： | 4 |
| 2 | New advances in radiomics of gastrointestinal stromal tumors显示文摘Gastrointestinal stromal tumors(GISTs)are uncommon neoplasms of the gastrointestinal tract with peculiar clinical,genetic,and imaging characteristics.Preoperative knowledge of risk stratification and mutational status is crucial to guide the appropriate patients’treatment.Predicting the clinical behavior and biological aggressiveness of GISTs based on conventional computed tomography(CT)and magnetic resonance imaging(MRI)evaluation is challenging,unless the lesions have already metastasized at the time of diagnosis.Radiomics is emerging as a promising tool for the quantification of lesion heterogeneity on radiological images,extracting additional data that cannot be assessed by visual analysis.Radiomics applications have been explored for the differential diagnosis of GISTs from other gastrointestinal neoplasms,risk stratification and prediction of prognosis after surgical resection,and evaluation of mutational status in GISTs.The published researches on GISTs radiomics have obtained excellent performance of derived radiomics models on CT and MRI.However,lack of standardization and differences in study methodology challenge the application of radiomics in clinical practice.The purpose of this review is to describe the new advances of radiomics applied to CT and MRI for the evaluation of gastrointestinal stromal tumors,discuss the potential clinical applications that may impact patients’management,report limitations of current radiomics studies,and future directions. | Roberto Cannella Ludovico La Grutta Massimo Midiri Tommaso Vincenzo Bartolotta | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 3 | Health effects of air pollution:a Southern European perspective显示文摘Objective:To summarize the main updated evidence about the health effects of air pollution,with a special focus on Southern Europe.Data sources:Literature was obtained through PubMed Central and the official websites of European Agencies and Scientific Societies.Study selection:Recent shreds of evidence about the health effects of air pollution coming from international reports and original research were collected and described in this review.Results:Air pollution is an avoidable risk factor that causes a huge burden for society,in terms of death,health disorders,and huge socio-economic costs.The southern European countries face a more threatening problem because they experience the effects of both anthropogenic pollutants and natural dusts(particulate matter[PM]).The European Environment Agency reported the number of premature deaths in the 28 countries of the European Union attributable to air pollutant exposure in the year 2016:374,000 for PM2.5,68,000 for nitrogen dioxide,and 14,000 for ozone.In Italy,time series and analytical epidemiological studies showed increased cardiorespiratory hospital admissions and mortality,as well as increased risk of respiratory diseases in people living in urban areas.Conclusions:Based on abundant evidence,the World Health Organization,which hosts the Global Alliance against Chronic Respiratory Diseases(GARD),the scientific respiratory societies,and the patients’associations,as well as others in the health sector,must increase their engagement in advocacy for clean air policies. | Giovanni Viegi Sandra Baldacci Sara Maio Salvatore Fasola Isabella Annesi-Maesano Francesco Pistelli Laura Carrozzi Stefania La Grutta Francesco Forastiere | 2020 | Chinese Medical Journal2020，，13： | 2 |
| 4 | Drugs to be avoided in patients with long QT syndrome:Focus on the anaesthesiological management显示文摘Long QT syndrome incidence is increasing in general population.A careful pre-,peri-and post-operative management is needed for patients with this syndrome because of the risk of Torsades de Pointes and malignant arrhythmias.The available data regarding prevention of lethal Torsades de Pointes during anesthesia in patients with long QT syndrome is scant and conflicting:only case reports and small case series with different outcomes have been published.Actually,there are no definitive guidelines on pre-,peri-and post-operative anesthetic management of congenital long QT syndrome.Our review focuses on anesthetic recommendations for patients diagnosed with congenital long QT syndrome furnishing some key points for preoperative optimization,intraoperative anesthetic agents and postoperative care plan,which could be the best for patients with c-long QT syndrome who undergo surgery. | Giovanni Fazio Federica Vernuccio Giuseppe Grutta Giuseppe Lo Re | 2013 | World Journal of Cardiology2013，5，4： | 2 |
| 5 | Prevalence of myocardial bridging and correlation with coronary atherosclerosis studied with 64-slice CT coronary angiography显示文摘 | La Grutta L Runza G Lo Re G | | 0，，： | 1 |
| 6 | Prevalence of myoear dial bridging and correlation with coronary atherosclerosis studied with 64-slice CT coronary angiography显示文摘 | La Grutta L Runza G Lo Re G | 2009 | Radiol Med2009，114，7： | 1 |
| 7 | Non invasive ima- ging of myocardial infarction with computed tomography and magnetic resonance显示文摘 | Midiri M La Grutta L Grassedonio E | 2015 | Curt Vasc Pharmacol2015，13，1： | 1 |
| 8 | Strength of Bolted Joints in Composites under Concentrated Moment显示文摘 | Miskioglu I | 2000 | Journal of Composite Materials2000，34，15： | 1 |
| 9 | A cross-sectional study assessing the relationship between BMI,asthma,atopy,and eNO among schoolchildren显示文摘 | Cibella F Cuttitta G La Grutta S | | 0，，： | 1 |
| 10 | Diagnostic accuracy of 64-slice CT in the assessment of coronary stents显示文摘 | F. Cademartiri A. Palumbo E. Maffei L. Grutta G. Runza F. Pugliese M. Midiri N. R. A. Mollet W. B. Meijboom A. Menozzi L. Vignali C. Reverberi D. Ardissino G. P. Krestin | 2007 | La radiologia medica2007，，4： | 1 |
| 11 | Prevalence of anatomical variants and coronary anomalies in 543 consecutive patients studied with 64-slice CT coronary angiography显示文摘 | Cademartiri F La Grutta L Malagò R | 2008 | Eur Radiol2008，18，4： | 1 |
| 12 | Safety of sublingual-swal- low immunotherapy in children aged 3 to 7 years显示文摘 | Fiocchi A Pajno G La Grutta S | 2005 | Ann Allergy Asthma Immunol2005，95，3： | 1 |
| 13 | Nitric oxide and glutamate interaction in the control of cortical and hippocampal excitability显示文摘 | Ferraro G Montalbano ME La Grutta V | 1999 | Epilepsia1999，40，7： | 1 |
| 14 | Nitric oxide and glutamate interaction in the control of cortical and hippocampal excitability显示文摘 | Ferraro G Montalbano ME Grutta VL | 1999 | Epilepsia1999，40，7： | 1 |
| 15 | Multiple in vitro and in vi- vo regulatory effects of budesonide in CIM + T lymphocyte subpop- ulations of allergic asthmatics 显示文摘 | Pace E Di Sano C La Grutta S | 2012 | PLoS One2012，7，48： | 1 |
| 16 | CD4+ IL-13+ cells in pe- ripheral blood well correlates with the severity of atopicdermatitis in children显示文摘 | Grutta SL Richirsa P Pizzolanti G | 2005 | Allergy2005，60，3： | 1 |
| 17 | Imaging techniques for the vulnerable coronary plaque 显示文摘 | Cademartiri F La Grutta L Palumbo A | 2009 | Radiol Med2009，112，5： | 1 |
| 18 | Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years显示文摘 | Fiocchi A Pajno G La Grutta S | 2005 | Ann Allergy Asthma Immunol2005，95，3： | 1 |
| 19 | Non-invasive markers of airway inflammation and remodeling in childhood asthma 显示文摘 | Gagliardo R La Grutta S Chanez P | 2009 | Pediatric Allergy and Immunology2009，20，8： | 1 |
| 20 | Prevalence of myocardial bridging and correlation with coronary atherosclerosis studied with 64-slice CT coronary angiograpby 显示文摘 | La Grutta L Ruaza G Lo ReG | 2009 | Radiol Med2009，114，7： | 1 |
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