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135篇 您的检索式：作者名="Grunwald A"

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	题名	作者	年代	出处	被引量
1	Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs.	Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth	2007	World Journal of Gastroenterology2007，13，48：	4
2	Design of a magnetostrictive (MS) actuator显示文摘	Grunwald A Olabi A G	2008	Sensors and Actuators2008，144，1：	1
3	Design and application ofmagnetorheological fluid显示文摘	OLABI A G GRUNWALD A	2007	Materials and Design2007，28，：	1
4	The normative basis of (health) technology assessment and the role of ethical expertise显示文摘	Grunwald A	2004	Poiesis Prax2004，2，2：	1
5	Phosphorus in agricultral ditch soil and potential impications for water qulity显示文摘	DUNNE E J McKEE K A GRUNWALD S	2007	Journal of Soil and Water Conseration2007，62，4：	1
6	Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in the Follow-up of Differentiated Thyroid Cancer显示文摘	Grunwald F Schomburg A Bender H	1996	Eur J Nucl Med1996，23，3：	1
7	Targeting vascular endothelial growth factor (VEGF)-recep- tor-signaling in renal cell carcinoma 显示文摘	Reuter C W Morgan M A Grunwald V	2007	World J Urol2007，25，1：	1
8	A global sensitivity analysis tool for the parameters of multi-variable catchment models显示文摘	VAN GRIENSVEN A MEIXNER T GRUNWALD S	2006	Journal of Hydrology2006，324，14：	1
9	Comparative study of nail sampling techniques in onychomycosis显示文摘	Shemer A Davidovici B Grunwald MH	2009	J Dermatol2009，36，7：	1
10	Development of an environmental virtual field laboratory 显示文摘	Ramasundaram V Grunwald S Mangeot A	2005	Computers & Education2005，45，1：	1
11	Functional status of peripheral blood T-cells in ischemic stroke patients显示文摘	Vogelgesang A May VE Grunwald U	2010	PLoS One2010，5，：	1
12	Design and application of magnetorheological fluid显示文摘	OLABI A G GRUNWALD A	2007	Materials and Design2007，28，：	1
13	Recent and advances in SAW packaging显示文摘	SELMEIER P GRUNWALD R PRZADKA A	2001	IEEE Ultras Symp Proc2001，1，：	1
14	A Global Sensitivity Analysis Tool for the Parameters of Multi-variable Catchment Models显示文摘	GR1ENSVEN A MEIXNER T GRUNWALD S	2006	Journal of Hydrology2006，324，14：	1
15	A global sensitivity analysis tool for the parameters of multi-variable catchment models 显示文摘	Van Griensven A Meixner T Grunwald S	2006	Journal of Hydrology2006，324，1：	1
16	Design and Application of Magnetostrictive Materials 显示文摘	OLABI A G GRUNWALD A	2008	Materials & Design2008，29，：	1
17	Analysisof lymphocyte subsets in patients with stroke and their in-fluence on infection after stroke 显示文摘	Vogelgesang A Grunwald U LangnerS	2008	Stroke2008，39，1：	1
18	Functional status of peripheral blood T-Cells in ischemic stroke patients显示文摘	Vogelgesang A May VE Grunwald U	2010	PLoS One2010，5，1：	1
19	Analysis of lymphocyte subsets in patients with stroke and their influence on infection after stroke显示文摘	Vogelgesang A Grunwald U Langner S	2008	Stroke2008，39，1：	1
20	Dynamics of bacterial population in relation to carbon availability in a residue amended soil显示文摘	HU S J VAN BRUGGEN A H C GRUNWALD N J	1999	Applied Soil Ecology1999，13，：	1

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