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| 1 | Pancreatic adenocarcinoma:Outstanding problems显示文摘Pancreatic adenocarcinoma remains the fourth leading cause of cancer-related death and is one of the most aggressive malignant tumors with an overall 5-year survival rate of less than 4%.Surgical resection remains the only potentially curative treatment but is only possible for 15%-20% of patients with pancreatic adenocarcinoma.About 40% of patients have locally advanced nonresectable disease.In the past,determination of pancreatic cancer resectability was made at surgical exploration.The development of modern imaging techniques has allowed preoperative staging of patients.Institutions disagree about the criteria used to classify patients.Vascular invasion in pancreatic cancers plays a very important role in determining treatment and prognosis.There is no evidence-based consensus on the optimal preoperative imaging assessment of patients with suspected pancreatic cancer and a unified definition ofborderline resectable pancreatic cancer is also lacking.Thus,there is much room for improvement in all aspects of treatment for pancreatic cancer.Multi-detector computed tomography has been widely accepted as the imaging technique of choice for diagnosing and staging pancreatic cancer.With improved surgical techniques and advanced perioperative management,vascular resection and reconstruction are performed more frequently;patients thought once to be unresectable are undergoing radical surgery.However,when attempting heroic surgery,a realistic approach concerning the patient's age and health status,probability of recovery after surgery,perioperative morbidity and mortality and life quality after tumor resection is necessary. | Olga P Zakharova Grigory G Karmazanovsky Viacheslav I Egorov | 2012 | World Journal of Gastrointestinal Surgery2012，4，5： | 4 |
| 2 | Value of two-phase dynamic multidetector computed tomography in differential diagnosis of post-inflammatory strictures from esophageal cancer显示文摘AIM: To characterize the computed tomography(CT) findings in patients with post-inflammatory esophageal strictures(corrosive and peptic) and reveal the optimal scanning phase protocols for distinguishing postinflammatory esophageal stricture and esophageal cancer.METHODS: Sixty-five patients with esophageal strictures of different etiology were included in this study: 24 patients with 27 histopathologically confirmed corrosive strictures, 10 patients with 12 peptic strictures and 31 patients with esophageal cancer were evaluated with a two-phase dynamic contrast-enhanced MDCT. Arterial and venous phases at 10 and 35 s after the attenuation of 200 HU were obtained at the descending aorta, with a delayed phase at 6-8 min after the start of injection of contrast media. For qualitative analysis, CT scans of benign strictures were reviewed for the presence/absence of the following features: 'target sign', luminal mass, homogeneity of contrast medium uptake, concentric wall thickening, conically shapedsuprastenotic dilatation, smooth boundaries of stenosis and smooth mucous membrane at the transition to stenosis, which were compared with a control group of 31 patients who had esophageal cancer. The quantitative analysis included densitometric parameter acquisition using regions-of-interest measurement of the zone of stenosis and normal esophageal wall and the difference between those measurements(ΔCT) at all phases of bolus contrast enhancement. Esophageal wall thickening, length of esophageal wall thickening and size of the regional lymph nodes were also evaluated. RESULTS: The presence of a concentric esophageal wall, conically shaped suprastenotic dilatation, smooth upper and lower boundaries, 'target sign' and smooth mucous membrane at the transition to stenosis were suggestive of a benign cause, with sensitivities of 92.31%, 87.17%, 94.87%, 76.92% and 82.05%, respectively, and specificities of 70.96%, 89.66%, 80.65%, 96.77% and 93.55%, respectively. The features that were most suggestive of a malignant cause were eccentric esophageal wall thickening, tuberous upper and lower boundaries of stenosis, absence of mucous membrane visualization, rupture of the mucous membrane at the upper boundary of stenosis, cup-shaped suprastenotic dilatation, luminal mass and enlarged regional lymph nodes with specificities of 92.31% 94.87%, 67.86%, 100%, 97.44%, 94.87% and 82.86%, respectively and sensitivities of 70.97%, 80.65%, 96.77%, 80.65%, 54.84%, 87.10% and 60%, respectively. The highest tumor attenuation occurred in the arterial phase(mean attenuation 74.13 ± 17.42 HU), and the mean attenuation difference between the tumor and the normal esophageal wall(mean ΔCT) in the arterial phase was 23.86 ± 19.31 HU. Here, 11.5 HU of ΔCT in the arterial phase was the cut-off value used to differentiate esophageal cancer from post-inflammatory stricture(P = 0.000). The highest attenuation of postinflammatory strictures occurred in the delayed phase(mean attenuation 71.66 ± 14.28 HU), and the mean ΔCT in delayed phase was 34.03 ± 15.94 HU. Here, 18.5 HU of ΔCT in delayed phase was the cut-off value used to differentiate post-inflammatory stricture from esophageal cancer(P < 0.0001).CONCLUSION: The described imaging findings reveal high diagnostic significance in the differentiation of benign strictures from esophageal cancer. | Grigory G Karmazanovsky Svetlana A Buryakina Evgeny V Kondratiev Qin Yang Dmitry V Ruchkin Dmitry V Kalinin | 2015 | World Journal of Gastroenterology2015，21，29： | 3 |
| 3 | COVID-19 and liver injury: An ongoing challenge显示文摘The new coronavirus severe acute respiratory syndrome coronavirus 2(SARSCoV-2)was identified in December 2019,in Wuhan,China.The virus was rapidly spread worldwide,causing coronavirus disease 2019(COVID-19)pandemic.Although COVID-19 is presented,usually,with typical respiratory symptoms(i.e.,dyspnea,cough)and fever,extrapulmonary manifestations are also encountered.Liver injury is a common feature in patients with COVID-19 and ranges from mild and temporary elevation of liver enzymes to severe liver injury and,even,acute liver failure.The pathogenesis of liver damage is not clearly defined;multiple mechanisms contribute to liver disorder,including direct cytopathic viral effect,cytokine storm and immune-mediated hepatitis,hypoxic injury,and druginduced liver toxicity.Patients with underlying chronic liver disease(i.e.,cirrhosis,non-alcoholic fatty liver disease,alcohol-related liver disease,hepatocellular carcinoma,etc.)may have greater risk to develop both severe COVID-19 and further liver deterioration,and,as a consequence,certain issues should be considered during disease management.The aim of this review is to present the prevalence,clinical manifestation and pathophysiological mechanisms of liver injury in patients with SARS-CoV-2 infection.Moreover,we overview the association between chronic liver disease and SARS-CoV-2 infection and we briefly discuss the management of liver injury during COVID-19. | Ioanna Papagiouvanni Serafeim-Chrysovalantis Kotoulas Athanasia Pataka Dionisios G Spyratos Konstantinos Porpodis Afroditi K Boutou Georgios Papagiouvannis Ioanna Grigoriou Christos Vettas Ioannis Goulis | 2023 | World Journal of Gastroenterology2023，29，2： | 2 |
| 4 | RGDS peptides immobilized on titanium alloy stimulatebone cell attachment, differentiation and conferresistance to apoptosis显示文摘 | SECCHI A G GRIGORIOU V SHAPIRO IM | 2007 | J Biomed Mater Res A2007，83，3： | 1 |
| 5 | Phase Synchronization of Chaotic Oscillators by External Driving显示文摘 | Arkady S P Michael G R Grigory V O | 1997 | Physica D : Nonlinear Phenomena1997，104，34： | 1 |
| 6 | Impact of isolated teratozoospermia on the outcome of intrauterine insemination显示文摘 | Grigoriou O Pantos K Makrakis E Hassiakos D Konidaris S Creatsas G | 2005 | Fertil Steril2005，83，3： | 1 |
| 7 | Regression of endometrial hyperplasia after treatment with the gonadotrophin-releasing hormone analogue triptorelin : a prospective study 显示文摘 | Grigoris G Tryfon T Valentini T | 1999 | Human Reproduction1999，14，2： | 1 |
| 8 | A study on pitting behavior of AA2024/SiCp composites using the double cycle polarization technique显示文摘 | Grigoris E K Stefanos M S Eleni G P | 1999 | Corrosion Sci- ence1999，41，： | 1 |
| 9 | Regression of endometrial hyperplasia after treatment with the gonadotrophin releasing hormone analogue triptorelin:a prospective study显示文摘 | Grigoris G Tsalikis T Tzioufa V | 1999 | Human Reproduction1999，14，： | 1 |
| 10 | Char- acterization of a silicon thermal gas flow sensor with porous silicon thermal isolation 显示文摘 | Grigoris K Athanase A G Nassiopoulos A G | 2002 | IEEE Sensor Journal2002，2，5： | 1 |
| 11 | Fgf - 8 determines rostral- caudal polarity in the first branchial arch 显示文摘 | Tucker AS Yamada G Grigoriou M | 1999 | Development1999，126，1： | 1 |
| 12 | Fgf-8 determines rostral-caudal polarity in the first branchial arch显示文摘 | Tucker AS Yamada G Grigoriou M | 1999 | Development1999，126，1： | 1 |
| 13 | Protective effects of nanostructures of hydrated C 60 fullerene on reproductive function in streptozotocin-diabetic male rats显示文摘 | Ramazan Bal Gaffari Türk Mehmet Tuzcu Okkes Yilmaz Ibrahim Ozercan Tuncay Kuloglu Seyfettin Gür Victor S. Nedzvetsky Artem A. Tykhomyrov Grigory V. Andrievsky Giyasettin Baydas Mustafa Naziroglu | 2010 | Toxicology2010，，3： | 1 |
| 14 | A study on pitting behavior of AA2024/SiCp composites using the double cycle polarization technique显示文摘 | Stefanos M S Eleni G P | 1999 | Corrosion Science1999，41，： | 1 |
| 15 | RGDS Peptides Immobilized on Titanium Alloy Stimulate Bone Cell Attachment, Differentiation and Confer Resistance to Apoptosis显示文摘 | Seochi A G Grigoriou V Shapiro I M | 2007 | Journal of Biomedical Materials Research Part A2007，83，3： | 1 |
| 16 | Synthesis and characterisation of hexagonal molybdenum nitrides 显示文摘 | Alexey Y G Lorenz K Grigori V V | 2006 | J Solid State Chem2006，，179： | 1 |
| 17 | 在腹的外科的帮助机器人的操作的虚拟建模显示文摘 AIM:To determine the effectiveness of using multidetector computed tomography(MDCT)data in preoperative planning of robot-assisted surgery.METHODS:Fourteen patients indicated for surgery underwent MDCT using 64 and 256-slice MDCT.Before the examination,a specially constructed navigation net was placed on the patient’s anterior abdominal wall.Processing of MDCT data was performed on a Brilliance Workspace 4(Philips).Virtual vectors that imitate robotic and assistant ports were placed on the anterior abdominal wall of the 3D model of the patient,considering the individual anatomy of the patient and the technical capabilities of robotic arms.Sites for location of the ports were directed by projection on the roentgen-positive tags of the navigation net.RESULTS:There were no complications observed during surgery or in the post-operative period.We were able to reduce robotic arm interference during surgery.The surgical area was optimal for robotic and assistant manipulators without any need for reinstallation of the trocars.CONCLUSION:This method allows modeling of the main steps in robot-assisted intervention,optimizing operation of the manipulator and lowering the risk of injuries to internal organs. | Stanislav V Berelavichus Grigory G Karmazanovsky Vadim S Shirokov Valeriy A Kubyshkin Andrey G Kriger Evgeny V Kondratyev Olga P Zakharova | 2012 | World Journal of Gastrointestinal Surgery2012，4，6： | 0 |
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