|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 欧洲新生儿呼吸窘迫综合征防治指南-2010版显示文摘呼吸窘迫综合征(RDS)是由于肺表面活性物质(PS)缺乏及肺结构发育不成熟所致,多见于早产儿,自然病程为生后当时或很快发病,并在生后2d内进行性恶化,如不及时治疗,因进行性缺氧和呼吸衰竭而死亡,存活者,在生后2—4d病情开始改善。胎龄越小,RDS发生率越高,2006年EuroNeoStat的数据显示:胎龄23~25周的早产儿RDS发生率为91%, | Sweet DG Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 袁琳(翻译) 陈超(审校) | 2011 | 中华儿科杂志2011，49，1： | 137 |
| 2 | 欧洲新生儿呼吸窘迫综合征防治共识指南:2016版显示文摘新生儿呼吸窘迫综合征(RDS)是早产儿的重要疾病,尽管治疗手段不断成熟,低龄早产儿存活率逐渐增高,但支气管肺发育不良(BPD)发病率也随之升高,其中部分原因是减少了出生后激素的使用.2006年以来,来自欧洲许多国家的新生儿专家每3年一次回顾最新文献,就RDS或有RDS风险早产儿的防治达成共识,立志于改善欧洲新生儿的预后.欧洲RDS防治指南2007年开始发布,2010年和2013年进行了更新,期间获得了欧洲围产医学学会的大力支持.RDS是由于肺表面活性物质(PS)缺乏导致生后早期出现呼吸窘迫,典型临床表现随着防治手段的改进发生了巨大变化. | DavidG.Sweet Virgilio Carnielli Gorm Greisen Mikko Hallman Eren Ozek Richard Plavka Ola Didrik Saugstad Umberto Simeoni Christian P. Speer Maximo Vento Gerard H. A. Visser Henry L. Halliday | 2017 | 中华儿科杂志2017，55，3： | 90 |
| 3 | 欧洲早产儿呼吸窘迫综合征防治共识指南(2013版)显示文摘本次指南更新包括了自2010年以来Cochrane系统评价和医学文献中的最新证据,并采纳了一种新的证据评估分级系统(GRADE)。以往关于早期肺表面活性物质和持续气道正压通气治疗的推荐目前拥有了更坚定的循证依据。对产房复苏、稳定生命体征等内容进行了较大扩充。生命体征稳定后的氧疗目前仍存在一定的争议,但是在获得更多的证据之前,血氧饱和度的目标范围不应低于90%,支持治疗对于超早早产儿仍然极为重要。指南对其他注意事项进行了缩减。 | Sweet D Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 王敏婕 袁琳 陈超 | 2014 | 中华儿科杂志2014，52，10： | 34 |
| 4 | 欧洲新生儿呼吸窘迫综合征防治共识显示文摘呼吸窘迫综合征(RDS)是由于肺表面活性物质(PS)缺乏及肺结构发育不成熟所致,多见于早产儿,自然病程为出生当时或生后很快发病,并在生后2d内进行性恶化,如不及时治疗,因进行性缺氧和呼吸衰竭而死亡。存活者出生后2—4d病情开始改善。RDS临床表现早期出现呼吸窘迫如紫绀、呻吟、吸凹和呼吸急促,然后进一步发展为呼吸衰竭,血气分析结果可提示呼吸衰竭的严重性。胸部X线典型的毛玻璃样改变和支气管充气征可以确诊。Vermont Oxford新生儿协作网对RDS的定义为: | Sweet D Bevilacqua G Carnielli V Greisen G Plavka R Didrik Saugstad O Simeoni U Speer CP Valls-I-Soler A Halliday H 袁琳(译) 陈超(译) 杜立中(校) | 2008 | 中华儿科杂志2008，46，1： | 17 |
| 5 | A structural and data-driven approach to engineering a plant cytochrome P450 enzyme显示文摘Functional manipulation of biosynthetic enzymes such as cytochrome P450 s(or P450 s) has attracted great interest in metabolic engineering of plant natural products.Cucurbitacins and mogrosides are plant triterpenoids that share the same backbone but display contrasting bioactivities.This structural and functional diversity of the two metabolites can be manipulated by engineering P450 s.However,the functional redesign of P450 s through directed evolution(DE) or structure-guided protein engineering is time consuming and challenging,often because of a lack of high-throughput screening methods and crystal structures of P450 s.In this study,we used an integrated approach combining computational protein design,evolutionary information,and experimental data-driven optimization to alter the substrate specificity of a multifunctional P450(CYP87 D20)from cucumber.After three rounds of iterative design and evaluation of 96 protein variants,CYP87 D20,which is involved in the cucurbitacin C biosynthetic pathway,was successfully transformed into a P450 mono-oxygenase that performs a single specific hydroxylation at C11 of cucurbitadienol.This integrated P450-engineering approach can be further applied to create a de novo pathway to produce mogrol,the precursor of the natural sweetener mogroside,or to alter the structural diversity of plant triterpenoids by functionally manipulating other P450 s. | Dawei Li Yongshuo Ma Yuan Zhou Junbo Gou Yang Zhong Lingling Zhao Lida Han Sergey Ovchinnikov Ling Ma Sanwen Huang Per Greisen Yi Shang | 2019 | Science China(Life Sciences)2019，62，7： | 5 |
| 6 | European Consensus Guidelines on the Management of Neonatal Respiratory Distress Syndrome in Preterm Infants - 2013 Update显示文摘 | Sweet David G Carnielli Virgilio Greisen Gorm Hallman Mikko Ozek Eren Plavka Richard Saugstad Ola D Simeoni Umberto Speer Christian P Vento Maximo Halliday Henry L | 2013 | Neonatology2013，，4： | 3 |
| 7 | Acute pain induces insulin resistance in humans显示文摘 | Greisen J Juhl CB Grfte T | 2001 | Anesthesiology2001，95，3： | 1 |
| 8 | PCR primers and probesfor the 16SrRNA gene of most species of pathogenic bacteria, including bacteria found in cerebrospinal fluid显示文摘 | Greisen K Loeffelholz M Purohit A | 1994 | Journal of clinical microbiology1994，32，2： | 1 |
| 9 | Earlyeventsin canine distemper demyelinating encephalomyelitis显示文摘 | SUMMERS B A GREISEN H A APPEL M J G | 1979 | Acta Neuropathologica1979，52，： | 1 |
| 10 | Acute pain induces insulin resistance in humans显示文摘 | Greisen J Juhl CB Grofte T | 2001 | Anesthesiology2001，95，3： | 1 |
| 11 | The European guidelines for prevention and treatment of neonatal respiratory distress syndrome 显示文摘 | Sweet D G Carnielli V Greisen G | 2010 | Neonatology2010，97，4： | 1 |
| 12 | European consensusguidelines on the management of neonatal respiratory distress syn-drome in preterm infants-2013 update 显示文摘 | Sweet DG Camielli V Greisen G | 2013 | Neonatology2013，103，4： | 1 |
| 13 | European consensusguidelines on the management of neonatal respiratorydistress syndrome in preterm infants-2010 update显示文摘 | Sweet DG Carnielli V Greisen G | 2010 | Neonatology2010，97，4： | 1 |
| 14 | The SafeBoosC phase IIrandomised clinical trial : a treatment guideline for targeted near-infrared-derived cerebral tissue oxygenation versus standard treatment in extremelypreterm infants显示文摘 | Pellicer A Greisen G Benders M | 2013 | Neonatology2013，104，3： | 1 |
| 15 | Effects of leptin on basal and FSH stimulated steroidogenesis in human granulosaluteal cells 显示文摘 | Ledet T Moller N Christiansen JS Petersen K Ovesen P | 2000 | Acta Obstet Gynecol Scand2000，79，11： | 1 |
| 16 | Europearl consensus guidelines on the management of neonatal respiratory distress syndrome in pre- term ilffants - 2010 update 显示文摘 | Sweet DG Camielli V Greisen G | 2010 | Neonatology2010，97，4： | 1 |
| 17 | Follow-up of neonateswith total serum bilirubin levels ≥25 mg/dL:a danish populationbased study显示文摘 | Vandborg PK Hansen BM Greisen G | 2012 | Pediatrics2012，130，1： | 1 |
| 18 | European consensus guide lines on the management of neonatal respiratory distress syndrome in- proterm infants-2010 update显示文摘 | Sweet DG Carnielli V Greisen G | 2010 | Neonatology2010，97，4： | 1 |
| 19 | European consensus guide-lines on the management of neonatal respiratory distress syndrome in pmterm infants-2010 update 显示文摘 | SWEET D G CARNIELLI V GREISEN G | 2010 | Neonatology2010，97，4： | 1 |
| 20 | Surfactant therapy and nasal continuous positive airway pressure for newborns with respiratory distress syndrome 显示文摘 | Verder H Robertson B Greisen G | 1994 | N Engl J Med1994，331，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员