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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 3 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3hkno5xqf06w966xfw.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 4 | Elastic wave velocities in heterogeneous and porous media 显示文摘 | Wyllie M R J Gregory A R Gardner L W | 1956 | Geophysics1956，21，1： | 1 |
| 5 | Trl cells: from discovery to their clinical application 显示文摘 | Battaglia M Gregori S Bacchetta R | 2006 | Semin Immunol2006，18，： | 1 |
| 6 | Optimal capacity of p-persis- tent CSMA protocols显示文摘 | BRUNO R CONTI M GREGORI E | 2003 | IEEE Communication Letters2003，7，3： | 1 |
| 7 | Geno- type-phenotype con elation in X-linked Alport syndrome显示文摘 | BEKHEIRNIA M R REED B GREGORY M C | 2010 | Jo- urnal of the American Society of Nephrology (JASN)2010，21，5： | 1 |
| 8 | Cyclooxygenase-2 inhi-bition delays the attainment of peak woven bone formationfollowing four-point bending in the rat 显示文摘 | GREGORY L S FORWOOD M R | 2007 | Caleif Tiss2007，80，3： | 1 |
| 9 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 10 | Genetic and phenotypic (co)variances for growth and carcass traits of purebred and composite populations of beef cattle 显示文摘 | GREGORY K E CUNDIFF L V KOCH R M | 1995 | Journal of Animal Science1995，73，： | 1 |
| 11 | Aging effect on the reflectivity measurements of polychloroprene matrices containing carbon black and carbonyl-iron powder显示文摘 | Pinho M S Gregori M L Nunes R C R Soares B G | 2001 | Polymer Degradation and Stability2001，73，： | 1 |
| 12 | Im-mune evasion genes from filarial nematodes显示文摘 | Maizels R M Gomez E N* Gregory W F | 2001 | Int JParasitol2001，31，9： | 1 |
| 13 | Elastic wave velocities in heterogeneous and porous media 显示文摘 | Wyllie M R J Gregory A R and Gardner L W | 1956 | Geophysics1956，21，1： | 1 |
| 14 | Predictor-based Model Reference Adaptive Control显示文摘 | E Lavretsky R Gadient I M Gregory | 2010 | Journal of Guidance Control and Dynamics2010，33，4： | 1 |
| 15 | Coconuts in Miocene turbidites in New Zealand: possible evidence for tsunami origin of some turbidity currents 显示文摘 | Ballance P F Gregory M R Gibson G W | 1981 | Geology1981，9，12： | 1 |
| 16 | Elastic wave velocities in heterogeneous and porous media显示文摘 | Wyllie M R J Gregory A R Gardner L W | 1956 | Geophysics1956，21，1： | 1 |
| 17 | MR imaging evaluation of endometrial carcinoma:results of an NCI cooperative study显示文摘 | Hedvig H Lawrence V R Gregory M G | 1991 | Radiology1991，179，6： | 1 |
| 18 | An experimental investigation of factors affecting elastic wave velocities in porous media显示文摘 | Wyllie M R J Gregory A R and Gardner L W | 1958 | 23 (3) : 459-4931958，23，3： | 1 |
| 19 | Metastasis to the Pancreas from Breast Cancer:Difficulties in Diagnosis and Controversies in Treatment显示文摘 | Bonapasta SA Gregori M Lanza R | | 0，，： | 1 |
| 20 | Trl cells:from discovery to their clinical appfication显示文摘 | Battaglia M Gregori S Bacchetta R | 2006 | Semin Immunol2006，18，2： | 1 |
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