|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Carotid Intima-media Thickness Measurements: Relations with Atherosclerosis, Risk of Cardiovascular Disease and Application in Randomized Controlled Trials显示文摘INTRODUCTION Cardiovascular disease (CVD) is the leading cause of death worldwide and contributes considerably to morbidity[1-3] The underlying cause is atherosclerosis.[4] The development of new preventive therapies is one of the steps to control the CVD epidemic.It is increasingly demanded that promising therapies be evaluated in trials using cardiovascular (CV) morbidity and mortality (M and M) as a primary outcome.[5] | Michiel L Bots Gregory W Evans Charles H Tegeler Rudy Meijer | 2016 | Chinese Medical Journal2016，，2： | 15 |
| 2 | 中国老年心房颤动优化抗凝管理注册研究一年结果显示文摘目的研究旨在探讨合并多种疾病的老年心房颤动(房颤)患者的优化抗凝管理策略。方法中国老年房颤患者优化抗栓管理注册研究(ChiOTEAF研究)是一项前瞻性、多中心、真实世界的注册研究。2014年10月至2018年12月在全国44家中心招募老年房颤患者,随访1年的血栓栓塞、出血、急性冠状动脉综合征和全因死亡发生情况。使用Cox风险比例模型分析抗凝治疗对血栓、出血及全因死亡复合临床事件的影响。结果本研究共招募7073例房颤患者,其中6148例完成1年随访,年龄(74.3±10.5)岁,年龄范围65~92岁,其中女患者占39.4%(2422/6148)。非维生素K拮抗剂口服抗凝药(NOACs)、华法林和抗血小板药物的使用率分别为23.5%(1444/6148)、21.1%(1300/6148)和41.0%(2521/6148)。48.6%(2988/6148)患者同时存在CHA2DS2-VASc和HAS-BLED评分高危,49.6%(3052/6148)患者HAS-BLED评分≥3。42.3%(2601/6148)患者有跌倒风险,34.2%(2102/6148)患者合并心力衰竭,17.3%(1064/6148)患者年龄≥85岁,14.3%(878/6148)合并慢性肾脏病/肝病,9.0%(555/6148)合并恶性肿瘤。校正基线特征后,房颤合并CHA2DS2-VASc和HAS-BLED高危、HAS-BLED≥3、跌倒风险、慢性肾脏病/肝病、年龄≥85岁等患者,抗凝治疗较抗血小板治疗降低急性心肌梗死、缺血性脑卒中、脑出血和全因死亡的复合终点事件风险(均P<0.05)。结论权衡血栓及出血风险后,老年高危房颤患者抗凝治疗降低临床不良事件。 | 郭豫涛 王玉堂 单兆亮 时向民 奚国荣 王浩 Lip Gregory Y H | 2020 | 中华心律失常学杂志2020，24，4： | 13 |
| 3 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 4 | 静脉血栓栓塞显示文摘静脉血栓栓塞,包括深静脉血栓形成与肺动脉栓塞,普通可见,在医院和院外均可进行治疗主要危险因素包括年龄、近期手术(特别是整形手术)、癌症及血栓形成倾向已确立的治疗有普通肝素、低分子量肝素。 | Andrew D Blann Gregory Y H Lip 刘仁斌(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 6 |
| 5 | State of the science and challenges of breeding landscape plants with ecological function显示文摘Exotic plants dominate esthetically-managed landscapes,which cover 30–40 million hectares in the United States alone.Recent ecological studies have found that landscaping with exotic plant species can reduce biodiversity on multiple trophic levels.To support biodiversity in urbanized areas,the increased use of native landscaping plants has been advocated by conservation groups and US federal and state agencies.A major challenge to scaling up the use of native species in landscaping is providing ornamental plants that are both ecologically functional and economically viable.Depending on ecological and economic constraints,accelerated breeding approaches could be applied to ornamental trait development in native plants.This review examines the impact of landscaping choices on biodiversity,the current status of breeding and selection of native ornamental plants,and the interdisciplinary research needed to scale up landscaping plants that can support native biodiversity. | H Dayton Wilde Kamal J K Gandhi Gregory Colson | 2015 | Horticulture Research2015，2，1： | 2 |
| 6 | Aflatoxin Exposure and Viral Hepatitis in the Etiology of Liver Cirrhosis in The Gambia, West Africa显示文摘 | Kuniholm Mark H Lesi Olufunmilayo A Mendy Maimuna Akano Aliu O Sam Omar Hall Andrew J Whittle Hilton Bah Ebrima Goedert James J Hainaut Pierre Kirk Gregory D | 2008 | Environmental Health Perspectives2008，，11： | 2 |
| 7 | Silkbased biomaterials显示文摘 | FRANK Diaz DAVID L Kaplan | 2003 | Biomaterials2003，，24： | 1 |
| 8 | Formation velocity and density-The diagnostic basis for stratigraphic traps 显示文摘 | Gardner G H F Gardner L W Gregory A R | 1974 | Geophysics1974，39，6： | 1 |
| 9 | Relative importance of charge neutralization and precipitation on coagulation of kaolin with PACI: effect of sulfate ion 显示文摘 | Wang D S Tang H Gregory J | 2002 | Environmental Science & Tech nology2002，36，： | 1 |
| 10 | Silk-based biomaterials 显示文摘 | Gregory H Frank D Caroline J | 2003 | Biomaterials2003，24，3： | 1 |
| 11 | Oxygen isotope exchange kinetics of mineral pairs in closed and open systems: applications to problems of hydrothermal alteration of igneous rocks and Precambrian iron formations显示文摘 | GREGORY R T CRISS R E TAYLOR H P Jr | 1989 | Chem Geol1989，75，： | 1 |
| 12 | A Tutorial on Visual Servo Control显示文摘 | Seth H Gregory D H Peter I C | 1996 | IEEE Trans on Robotics and Automation1996，12，65： | 1 |
| 13 | Medical Therapy for Pulmonary Arteri- al Hypertension: updated ACCP evidence-based clinical practice guidelines 显示文摘 | David B Steve H Gregory S | 2004 | Chest2004，126，17： | 1 |
| 14 | Silk-based biomaterials显示文摘 | Gregory H Altman Frank Diaz Caroline Jakuba Tara Calabro Rebecca L Horan Jingsong Chen Helen Lu John Richmond David L Kaplan | 2002 | Biomaterials2002，，3： | 1 |
| 15 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 16 | Diffusion of ions in sea water and in deep-sea sediments显示文摘 | Li Y H Gregory S | 1974 | Geochimica et Cosmochimica Acta1974，38，5： | 1 |
| 17 | Gennetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy显示文摘 | Furuya H Fernandez-Salguero P Gregory W | 1995 | Pharmacogenetics1995，5，6： | 1 |
| 18 | The P21 inhibitor of cyclyin dependent kinases control DNA replication by interaction with PCAN 显示文摘 | SHOU W GREGORY G H DARID S | 1994 | Nature1994，369，： | 1 |
| 19 | Isolation and structure of urogastrone and its relation- ship to epidermal growth factor 显示文摘 | Gregory H | 1975 | Nature1975，257，5524： | 1 |
| 20 | Assessment of liver fibrosis by Transient Elastography in Persons with Hepatitis C Virus Infection or HIV-Hepatitis C Virus Coinfection显示文摘 | Gregory D Kirk Jacquie Astemborski Shruti H Mehta | 2009 | Clin infect Dis2009，48，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员