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| 1 | 在 7T 的多原子的磁性的回声光谱学的应用显示文摘 AIM: To discuss the advantages of ultra-high field (7T) for 1H and 13C magnetic resonance spectroscopy (MRS) studies of metabolism.made at both 3 and 7T using 1H MRS. Measurements of glycogen and lipids in muscle were measured using 13C and 1H MRS respectively. RESULTS: In the brain, increased signal-to-noise ratio (SNR) and dispersion allows spectral separation of the amino-acids glutamate, glutamine and γ-aminobutyric acid (GABA), without the need for sophisticated editing sequences. Improved quantification of these me-tabolites is demonstrated at 7T relative to 3T. SNR was 36% higher, and measurement repeatability (% coefficients of variation) was 4%, 10% and 10% at 7T, vs 8%, 29% and 21% at 3T for glutamate, glutamine and GABA respectively. Measurements at 7T were used to compare metabolite levels in the anterior cingulate cortex (ACC) and insula. Creatine and glutamate levels were found to be significantly higher in the insula compared to the ACC (P < 0.05). In muscle, the increased SNR and spectral resolution at 7T enables interleaved studies of glycogen (13C) and intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) (1H) following exercise and refeeding. Glycogen levels were sig-nificantly decreased following exercise (-28% at 50% VO2 max; -58% at 75% VO2 max). Interestingly, levels of glycogen in the hamstrings followed those in the quadriceps, despite reduce exercise loading. No changes in IMCL and EMCL were found in the study. CONCLUSION: The demonstrated improvements in brain and muscle MRS measurements at 7T will increase the potential for use in investigating human metabolism and changes due to pathologies. | Mary C Stephenson Frances Gunner Antonio Napolitano Paul L Greenhaff Ian A MacDonald Nadeem Saeed William Vennart Susan T Francis Peter G Morris | 2011 | World Journal of Radiology2011，3，4： | 2 |
| 2 | Dietary supple- ments for athletes:emerging trends and recurring themes 显示文摘 | Maughan RJ Greenhaff PL Hespel P | 2011 | J Sports Sci2011，29，1： | 1 |
| 3 | Pre-operative nutrition in neck of femur trial (POINT)- carbohydrate loading in patients with fragility hip fracture:study protocol for a randomised controlled trial显示文摘 | Moppett IK Greenhaff PL Ollivere BJ | 2014 | Trials2014，15，： | 1 |
| 4 | Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis显示文摘 | Greenhaff P L | 1994 | Appl Physiol1994，266，51： | 1 |
| 5 | Influence of oral creatine supplementationin of muscle torque during repeated bouts of maximal voluntary exercise in man 显示文摘 | Casey A Short AH< | 1993 | Clin Sci1993，84，： | 1 |
| 6 | The effect of oral creatine supplementation on running performance during maximal shorter term exercise in man 显示文摘 | Viru M Greenhaff PL | 1993 | J Physiol1993，467，： | 1 |
| 7 | Effect of oral creatine supplementation on skeletal muscle phosphocreatine resynthesis 显示文摘 | GREENHAFF PL BODIN K SODERLUND K | 1994 | Ammerican Journal of Physiology1994，266，： | 1 |
| 8 | The effects of increasing exercise intensity on muscle fuel utilization in human显示文摘 | VAN LOON LJ C GREENHAFF P L CONSTANTIN-TEODOSIU D | 2001 | J Physiol2001，536，1： | 1 |
| 9 | The importance ofpyruvate availability to PDC activation and anaplerosis in human skeletal muscle显示文摘 | CONSTANT1N-TEODOSIU D SIMPSON E J GREENHAFF P L | 1999 | Am J Physiol1999，276，： | 1 |
| 10 | The effect of oral creatine supplementatioin on skeletal muscle ATP degradation during repeated bouts of maximal voluntary exercise in man 显示文摘 | Donstantin-Teodosiu D Casey A | 1994 | J Physiol1994，476，： | 1 |
| 11 | Tbe involvement of the ubiquitin proteasome system in human skeletal muscle remodelling and atrophy显示文摘 | Murton KJ Constantin D Greenhaff PL | 2008 | Biochimica et biophysica acta Molecular basis of disease2008，1782，12： | 1 |
| 12 | Comparison of the effects of pre-exercise feeding of glucose, glycerol and placebo on endurance and fuel homeostasis in man显示文摘 | M Maughan RJ and Greenhaff PL | 1986 | Eur J Appl Physiol 55: 645-6531986，，： | 1 |
| 13 | Mechanisms regulating muscle mass during disuse atrophy and rehabilitation in humans显示文摘 | Marimuthu K Murton AJ Greenhaff PL | 2011 | J Appl Physiol2011，110，2： | 1 |
| 14 | Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man显示文摘 | Greenhaff PL Casey A Short AH | 1993 | Clin Sci1993，84，： | 1 |
| 15 | The effects of increasing exercise intensity on muscle fuel utilisation in humans显示文摘 | Vanloon L J Greenhaff P L Constantin-teodosiu D | 2001 | Joumal of Physiology2001，536，： | 1 |
| 16 | Skeletal muscle carni- tine accumulation alters fuel metabolism in resting human skeletal muscle 显示文摘 | Stephens FB Constantin - Teodosiu D Laith- waite D Simpson EJ & Greenhaff PL | 2006 | J Clin Endocrinol Metab2006，91，： | 1 |
| 17 | The effects of increasing exercise intensity on muscle fuel utilisation in humans显示文摘 | van Loon LJ Greenhaff PL Constantin-Teodosiu D | | 0，，1： | 1 |
| 18 | The involvement of the ubiquitin proteasome system in human skeletal muscle remodelling and atrophy显示文摘 | Murton A J Constantin D Greenhaff PL | 2008 | Biochim Biophys Acta2008，1782，12： | 1 |
| 19 | The effect of oral creatine supplementation on skeletal muscle ATP degradation during repeated bouts of maximal voluntary exercise in man 显示文摘 | Greenhaff PL Donstantin Teodosiu D Casey A | 1994 | J Physiol1994，476，： | 1 |
| 20 | Muscle atrophy in immobilization and senescence in humans显示文摘 | Murton AJ Greenhaff PL | 2009 | Curr Opin Neurol2009，22，5： | 1 |
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