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| 1 | Mucosal healing progression after acute colitis in mice显示文摘BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little studied.AIM To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced colitis.METHODS C57 BL/6 male mice were given 3.5% dextran sodium sulfate(DSS) in drinking water for 5 d. They were euthanized 2(day 7), 5(day 10), 8(day 13), and 23(day28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory and repairing factors, and evaluation of colon mucosa-adherent microbiota composition by 16 S rRNA sequencing.RESULTS The maximal intensity of colitis was concomitant with maximal alterations of intestinal barrier function and histological damage associated with goblet cell depletion in colon mucosa. It was recorded 2 d after termination of the DSStreatment, followed by a progressive return to values similar to those of control mice. Although signs of colitis were severe(inflammatory cell infiltrate, crypt disarray, increased permeability) and associated with colonic luminal alterations(hyperosmolarity, dysbiosis, decrease in short-chain fatty acid content), epithelial healing processes were launched early during the inflammatory flare with increased gene expression of certain key epithelial repair modulators, including transforming growth factor-β, interleukin(Il)-15, Il-22, Il-33, and serum amyloid A. Whereas signs of inflammation progressively diminished, luminal colonic environment alterations and microscopic abnormalities of colon mucosa persisted long after colitis induction.CONCLUSION This study shows that colon repair can be initiated in the context of inflamed mucosa associated with alterations of the luminal environment and highlights the longitudinal involvement of key modulators. | Sandra Vidal-Lletjós Mireille Andriamihaja Anne Blais Marta Grauso Patricia Lepage Anne-Marie Davila Claire Gaudichon Marion Leclerc Francois Blachier Annaig Lan | 2019 | World Journal of Gastroenterology2019，25，27： | 5 |
| 2 | Four genes encode acetylcholinesterases in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae cDNA sequences,genomic structures,mutations and in vivo expression显示文摘 | Combes D Fedon Y Grauso M | 2000 | J Mol Biol2000，300，： | 1 |
| 3 | The Nicotinic Acetylcholine Receptor Gene Family of the Malaria Mosquito, Anopheles gambiae 显示文摘 | JONES A K GRAUSO M SATTELLE D B | 2005 | Genomics2005，85，： | 1 |
| 4 | Molecular cloning and expression of a full-length cDNA encoding acetylcholinesterase in optic lobes of the squid Loligo opalescens:A new member of the cholinesterase family resistant to diisopropyl fluorophosphates显示文摘 | Talesa V Grauso M Arpagaus M | 1999 | J Neuro-chem1999，72，： | 1 |
| 5 | Relations between climatic–geomorphological parameters and sediment yield in a mediterranean semi-arid area (Sicily, southern Italy)显示文摘 | Sergio Grauso Andrea Pagano Grazia Fattoruso Piero Bonis Filippo Onori Pasquale Regina Carlo Tebano | 2008 | Environmental Geology2008，，2： | 1 |
| 6 | Four genes encode acetylcholinesterases in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae, cDNA sequences, genomic structures, mutations and in vivo expression 显示文摘 | Combes D Fedon Y Grauso M | 2000 | Journal of Molecular Biology2000，300，： | 1 |
| 7 | Flow pattern map, heat transfer and pressure drops during evaporation of R-1234ze(E) and R134a in a horizontal, circular smooth tube: experiments and assessment of predictive methods 显示文摘 | GRAUSO S MASTRULLO R MAURO A W | 2013 | International Journal of Refrigeration2013，36，2： | 1 |
| 8 | Novel Putative Nicotinic Acetylcholine Receptor Subunit Genes,Dα5,Dα6 and Dα7,in Drosophila melanogaster Identify a New and Highly Conserved Target of Adenosine Deaminase Acting on RNA-mediated A-to-I Pre-mRNA Editing显示文摘 | GRAUSO M REENAN R A CULETTO E | 2002 | Genetics2002，160，： | 1 |
| 9 | Soil erosion prediction at the basin scale using the revised universal soil loss equation (RUSLE) in a catchment of Sicily ( southern Italy) 显示文摘 | Onori F De Bonis P Grauso S | 2006 | Environmental Geology2006，50，8： | 1 |
| 10 | The Nicotinic Acetylcholine Receptor Gene Family of the Malaria Mosquito,Anopheles gambiae显示文摘 | JONES A K GRAUSO M SATTELLE D B | 2005 | Genomics2005，85，： | 1 |
| 11 | Borderline ovarian tumors: features and controcersial aspects显示文摘 | Messali EM Grauso F Balbi G | 2013 | Eur J Obstet Gynecol ReprodBiol2013，167，： | 1 |
| 12 | Borderline ovarian tumors:features and con- troversial aspects 显示文摘 | Messalli EM Grauso F | 2013 | Eur J Obstet Gyneeol Reprod Biol2013，167，1： | 1 |
| 13 | Four Genes Encode Acetylcholinesterases in the Nematodes Caenorhabditis elegans and Caenorhabditis briggsae, cDNA Sequences, Genomic Structures, Mutations and in vivo Expression显示文摘 | COMBES D FEDON Y GRAUSO M | 2000 | J Mol Biol2000，300，： | 1 |
| 14 | CO2 and propane blends: Experiments and assessment of predictive methods for flow boiling in horizontal tubes 显示文摘 | GRAUSO S MASTRULLO R MAURO A W | 2011 | Int J Refrig2011，34，4： | 1 |
| 15 | Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zinc显示文摘 | Coddou C Morales B González J Grauso M Gordillo F Bull P | 2003 | J Biol Chem2003，278，36： | 1 |
| 16 | CO2 and propane blends: experiments and assessment of predictive methods for flow boiling in horizontal tubes 显示文摘 | Grauso S Mastrullo R Manro A W | 2011 | International Journal of Refrigeration2011，34，4： | 1 |
| 17 | Lipoprotein lipase regulation by insulin and glucocorticoid in subcutaneous and omental adipose tissues of obese women and men显示文摘 | Russell CD Grauso NL | 1993 | J Clin Invest1993，92，： | 1 |
| 18 | Soil erosion prediction at the basin scale using the revised universal soil loss equation(RUSLE)in a catchment of Sicily(southern Italy)显示文摘 | Onori F De Bonis P Grauso S | | 0，，： | 1 |
| 19 | Novel putative nicotinic acetylcholine receptor subunit genes,Dα5,Dα6 and Dα7,in Drosophila melanogaster identify a new and highly conserved target of adenosine deaminase acting on RNA-mediated A-to-I pre-mRNA editing显示文摘 | Grauso M Reenan R Culetto E | 2002 | Genetics2002，160，4： | 1 |
| 20 | The nicotinic acetylcholine receptor gene family of the malaria mosquito, Anopheles gambiae 显示文摘 | Jones A K Grauso M Sattelle D B | 2005 | Genomics2005，85，： | 1 |
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