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| 1 | Shaping the Firm' S External Search Strategy 显示文摘 | Granero A C Jurado J V Alegre J | 2014 | Innovation Management Policy and Prac- tices2014，16，3： | 1 |
| 2 | Levels of metals in soils of A-lcaláHenares,Spain:human health risks显示文摘 | Granero S Domingo J L | 2002 | EnvironmentInternational2002，28，： | 1 |
| 3 | PCDDs and PCDFs in Food Samples from Catalonia,Spain:An Assessment of Dietary Intake显示文摘 | Schuhmacher M Granero S | 1999 | Chemosphere1999，38，15： | 1 |
| 4 | Stability of valacyclovir:implications for its oral bioavailability显示文摘 | Granero GE Amidon GL | 2006 | Int J Pharm2006，317，1： | 1 |
| 5 | Trace element municipal solid waste incinerator: Human health risk显示文摘 | Schuhmacher M Meneses M Granero pollution of soils collected near a S | 1997 | Bulletin of Environmental Contamination and Toxicology1997，59，6： | 1 |
| 6 | Congener profile of PCDD/Fs in soil and vegetation samples collected near to a municipal waste incinerator显示文摘 | DOMINGO J L GRANERO S SCHUMACHER M | 2001 | Chemosphere2001，43，4567： | 1 |
| 7 | Rapid in vivo dissolution of ketoprofen: implications on the biopharmaceutics classification system显示文摘 | GRANERO GE RAMACHANDRAN C AMIDON GL | 2006 | Pharmazie2006，61，8： | 1 |
| 8 | Monitoring metals in the vicinity of a municipal waste incinerator: temporal variation in soils and vegetation 显示文摘 | Meneses M Llobet J M Granero S | 1999 | Science of the Total Environment1999，226，23： | 1 |
| 9 | Macrocephaly the first manifestation of glutaric aciduria type I: the importance of early diagnosis显示文摘 | Martinez Granero MA Garcia Perez A Martinez-Pardo M | 2005 | Neurologia2005，20，5： | 1 |
| 10 | 查看详情显示文摘 | Granero L Mico V Zalevsky Z Garcia J | | 0，，： | 1 |
| 11 | 查看详情显示文摘 | Granero L Zzlevsky Z Mico V | | 0，，： | 1 |
| 12 | Atmosphericdeposition of PCDD/Fs near an old municipal solid wasteincinerator: levels in soil and vegetation 显示文摘 | Schuhmachera M Granero S Rivera J | 2000 | Chemosphere2000，40，6： | 1 |
| 13 | Antiglycation and antioxidant activities of the crude extract and saponin fraction of Tribulus terrestris before and after microcapsule release显示文摘Objective:The present study investigated antiglycation and antioxidant activities of crude dry extract and saponin fraction of Tribulus terrestris.It also developed a method of microencapsulation and evaluated antiglycation and antioxidant activities of crude dry extract and saponin fraction before and after microcapsule release.Methods:Antiglycation activity was determined by relative electrophoretic mobility(REM),free amino groups and inhibition of advanced glycation end-product(AGE)formation.Antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl(DPPH),ferric ion-reducing antioxidant power(FRAP),nitric oxide(NO)and thiobarbituric acid reactive species(TBARS)tests.Microcapsules were prepared using maltodextrin as wall material and freeze-drying as encapsulation technique.Morphological characterization of microcapsules was evaluated by scanning electron microscopy,and encapsulation efficiency and microcapsule release were determined by total saponins released.Antiglycation and antioxidant assays were performed using crude dry extract and saponin fraction of T.terrestris before and after release.Results:Saponin fraction showed an increase of 32.8%total saponins.High-performance liquid chromatography-mass spectrometry analysis showed the presence of saponins in the obtained fraction.Antiglycation evaluation by REM demonstrated that samples before and after release presented antiglycation activity similar to bovine serum albumin treated with aminoguanidine.Additionally,samples inhibited AGE formation,highlighting treatment with saponin fraction after release(89.89%).Antioxidant tests demonstrated antioxidant activity of the samples.Crude dry extract before encapsulation presented the highest activities in DPPH(92.00%)and TBARS(32.49%)assays.Saponin fraction before encapsulation in FRAP test(499μmol Trolox equivalent per gram of dry sample)and NO test(15.13μmol nitrite formed per gram of extract)presented the highest activities.Conclusion:This study presented antiglycation activity of crude dry extract and saponin fraction of T.terrestris,besides it demonstrated promising antioxidant properties.It also showed that the encapsulation method was efficient and maintained biological activity of bioactive compounds after microcapsule release.These results provide information for further studies on antidiabetic and antiaging potential,and data for new herbal medicine and food supplement formulations containing microcapsules with crude extract and/or saponin fraction of T.terrestris. | Célia Cristina Malaguti Figueiredo Amanda da Costa Gomes Filipe Oliveira Granero Joao Luiz Bronzel Junior Luciana Pereira Silva Valdecir Farias Ximenes Regildo Márcio Goncalves da Silva | 2022 | Journal of Integrative Medicine2022，20，2： | 1 |
| 14 | Salsolinol and ethanol-derived exci- tation of dopamine mesolimbie neurons : new insights 显示文摘 | POLACHE A GRANERO L | 2013 | Front Behav Neurosci2013，7，： | 1 |
| 15 | Ternary complexes of Flurbiprofen with HP-β-CD and ethanolamines characterization and transdermal delivery显示文摘 | MAITRE M M LONGHI M R GRANERO G G | 2007 | Drug Dev Ind pharm2007，33，3： | 1 |
| 16 | The bicompletion of the Hausdorff quasi-uniformity显示文摘 | Hans-Peter A Künzi Romaguera S Sánchez Granero M A | 2009 | Topology Appl2009，156，： | 1 |
| 17 | Local salsolinol modulates dopamine extracellular levels from rat nucleus accumbens shell/core differences显示文摘 | HIPLITO L SNCHEZ-CATALN MJ GRANERO L | 2009 | Neurochem Int2009，55，4： | 1 |
| 18 | Kinetics of zinc transport in vitro in rat small intestine and colon:interaction with copper 显示文摘 | Condomina J Zornoza-Sabina T Granero L | 2002 | Eur J Pharm Sci2002，16，： | 1 |
| 19 | Levels of metals in soils of Alcaa de Henares,Spain:human health risks显示文摘 | Granero S D J L | 2002 | Environment International2002，28，： | 1 |
| 20 | Computerized analysis of respiratory sounds during COPD exacerbations显示文摘 | Sanchez Morillo D Astorga Moreno S Fernandez Granero MA | 2013 | Comput Biol Med2013，43，7： | 1 |
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