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	题名	作者	年代	出处	被引量
1	Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine.	Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o\|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer	2005	World Journal of Gastroenterology2005，11，44：	2
2	A soluble form of TRAP (CD40ligand) is rapidly released after T cell activation显示文摘	Graf D Muller S KorThauer U	1995	Eur J Immunol1995，，：	2
3	Brain natriuretic peptide levels predict functional capacity in patients with chronic heart failure显示文摘	Kruger S Graf J Kunz D		0，，04：	1
4	Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM显示文摘	Korthauer U Graf D Mages HW	1993	Nature1993，361，：	1
5	Clinical aspects of renal transplantation in polycycstic kidney disease 显示文摘	Stiasny B Ziebell D Graf S	2003	Clin Nephrol2003，58，1：	1
6	Cell fate determination during tooth develop- ment and regeneration 显示文摘	Mitsiadis TA Graf D	2009	Birth Defects Res C Embryo Today2009，87，3：	1
7	The IL-1 family member 7b translo-cates to the nucleus and down-regulates proinflammatory cyto-kines显示文摘	Sharma S’ Kulk N Nold MF Graf R Kim SH Reinhardt D Dinarello CA Bufler P	2008	J Immunol2008，180，8：	1
8	Absolute measurement of the resonator length of the free electron laser at the S DALINAC with a modulated semiconductor laser显示文摘	Genz H Gerstner K Graf H D	2003	Nuclear Instruments and Methods in Physics Research A2003，498，：	1
9	Use of procalcitonin to shorten antibiotic treatment duration in septic patients 显示文摘	Nobre V Harbarth S Graf J D	2008	Am J Respir Crit Care Med2008，177，5：	1
10	Prenatal diagnosis of fetal lymphocytes in the maternal blood显示文摘	Graf D Pan JW	1972	Obstet Gynecol1972，40，：	1
11	Molecular basis of down regulation of G-Protein-Coupled inward rectifying K^+ current in chronic human atrial fibrillation显示文摘	Dobrev D Graf E Wettwer E	2001	Circulation2001，104，：	1
12	Phase separation and the superfluid transition in liquid He^3 - He^4 mixtures 显示文摘	Graf E H Lee D M Reppy J D	1967	Physical Review Letters1967，19，8：	1
13	Mitogen activated protein kinase activate is involved in platelet derived growth factor directed migration by vascular smooth muscle cells显示文摘	Graf K Xi XP Yang D	1997	Hypertens1997，29，2：	1
14	Conservative treatment of cervical pregnancy by curettage and local prostaglandin injection 显示文摘	Spitzer D Steiner H Graf A	1997	Hum Reprod1997，12，4：	1
15	Care-O-bot Ⅱ--de- velopment of a next generation robotic home assistant 显示文摘	GRAF B HANS M SCHRAFTL R D	2004	Autonomous Robots2004，16，2：	1
16	SGKl dependence of insulin induced hypokalemia显示文摘	Boini KM Graf D Kuhl D	2009	Pflugers Arch2009，457，4：	1
17	Mitogen-activated pro- tein kinase activation is involved in platelet-derived growth factor-directed migration by vascular smooth muscle cells 显示文摘	GRAF K XI XP YANG D	1997	Hypertension1997，29，12：	1
18	The organizational impact of a new graduate pediatric nurse mentoring program显示文摘	Halfer D Graf E Sullivan C	2007	Nurs Econ2007，26，4：	1
19	Brain natriuretic peptide levels predict functional capacity in patients with chronic heart failure显示文摘	Kruger S Graf J Kunz D	2002	Am Coll Cardiol2002，40，：	1
20	Facial rejuvenation with SMASectomy and FAME using vertical vector显示文摘	GRAF R GROTH A K PACE D et at	2008	Aesthetic Plast Surg2008，32，4：	1

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