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| 1 | Antibiotic prophylaxis in variceal hemorrhage:Timing,effectiveness and Clostridium difficile rates显示文摘AIM:To investigate if antibiotics administered within 8 h of endoscopy reduce mortality or increase the incidence of Clostridium difficile infection(CDI).METHODS:A 2-year retrospective analysis of all patients who presented with first variceal hemorrhage was undertaken.The primary outcome measure was 28-d mortality.Secondary outcome measures were 28-d rebleeding rates and 28-d incidence of CDI.All patients were admitted to a tertiary liver unit with a consultantled,24-h endoscopy service.Patients received standard care including terlipressin therapy.Data collection included:primary and secondary outcome measures,timing of first administration of intravenous antibiotics,eti-ology of liver disease,demographics,endoscopy details and complications.A prospective study was undertaken to determine the incidence of CDI in the study population and general medical inpatients admitted for antibiotic therapy of at least 5 d duration.Statistical analysis was undertaken using univariate,non-parametric tests and multivariate logistic regression analysis.RESULTS:There were 70 first presentations of variceal hemorrhage during the study period.Seventy percent of cases were male and 65.7% were due to chronic alcoholic liver disease.In total,64/70(91.4%) patients received antibiotics as prophylaxis during their admission.Specifically,53/70(75.7%) received antibiotics either before endoscopy or within 8 h of endoscopy [peri-endoscopy(8 h) group],whereas 17/70(24.3%) received antibiotics at > 8 h after endoscopy or not at all(non peri-endoscopy group).Overall mortality and rebleeding rates were 13/70(18.6%) and 14/70(20%),respectively.The periendoscopy(8 h) group was significantly less likely to die compared with the non peri-endoscopy group [13.2% vs 35.3%,P = 0.04,odds ratio(OR) = 0.28(0.078-0.997)] and showed a trend towards reduced rebleeding [17.0% vs 29.4%,P = 0.27,OR = 0.49(0.14-1.74)].On univariate analysis,the non peri-endoscopy group [P = 0.02,OR = 3.58(1.00-12.81)],higher model for end-stage liver disease(MELD) score(P = 0.02),presence of hepatorenal syndrome [P < 0.01,OR = 11.25(2.24-56.42)] and suffering a clinical episode of sepsis [P = 0.03,OR = 4.03(1.11-14.58)] were significant predictors of death at 28 d.On multivariate logistic regression analysis,lower MELD score [P = 0.01,OR = 1.16(1.04-1.28)] and periendoscopy(8 h) group [P = 0.01,OR = 0.15(0.03-0.68)] were independent predictors of survival at 28 d.The CDI incidence(5.7%) was comparable to that in the general medical population(5%).CONCLUSION:Antibiotics administered up to 8 h following endoscopy were associated with improved survival at 28 d.CDI incidence was comparable to that in other patient groups. | Matthew RL Brown Graeme Jones Kathryn L Nash Mark Wright Indra Neil Guha | 2010 | World Journal of Gastroenterology2010，16，42： | 13 |
| 2 | Statin therapy is associated with fewer deaths in patients with bacteraemia显示文摘 | Peter Kruger Kenneth Fitzsimmons David Cook Mark Jones Graeme Nimmo | 2006 | Intensive Care Medicine2006，，1： | 2 |
| 3 | Constraint,Optimization and Hierarchy: Reviewing stereoscopic Correspondence of complex Features显示文摘 | Jones Graeme A | 1997 | Computer vision and image understanding January1997，65，1： | 1 |
| 4 | Screening for Antitumor Activity of 11 Species of Indonesian Zingiberaceae Using Human MCF-7 and HT-29 Cancer Cells显示文摘 | Chandra Kirana Ian R. Record Graeme H. McIntosh Graham P. Jones | 2003 | Pharmaceutical Biology2003，，： | 1 |
| 5 | Comparison of 11C-PiB and 18F-florbetaben for Aβ imaging in ageing and Alzheimer’s disease显示文摘 | Victor Villemagne Rachel Mulligan Svetlana Pejoska Kevin Ong Gareth Jones Graeme O’Keefe J. Chan Kenneth Young Henri Tochon-Danguy Colin Masters Christopher Rowe | 2012 | European Journal of Nuclear Medicine and Molecular Imaging2012，，： | 1 |
| 6 | Microwave ablation with or without resection for irresectable colorectal liver metastases显示文摘 | Stefan St?ttner Vincent S. Yip Robert P. Jones Kate Buchanan Graeme J. Poston Hassan Z. Malik Stephen W. Fenwick | 2013 | European Journal of Surgical Oncology2013，，： | 1 |
| 7 | The propolis of stingless bees: terpenes from the tibia of three Frieseomelitta species显示文摘 | E.F.L.R.A. Patricio Leopoldo Cruz-López Roland Maile Jutta Tentschert Graeme R. Jones E.David Morgan | 2002 | Journal of Insect Physiology2002，，2： | 1 |
| 8 | Enhanced recovery in the resection of colorectal liver metastases显示文摘 | Declan F. J. Dunne Vincent S. Yip Robert P. Jones Ewan A. McChesney Daniel T. Lythgoe Eftychia E. Psarelli Louise Jones Carmen Lacasia‐Purroy Hassan Z. Malik Graeme J. Poston Stephen W. Fenwick | 2014 | J. Surg. Oncol2014，，2： | 1 |
| 9 | Detection of meningococcal carriage by culture and PCR of throat swabs and mouth gargles显示文摘 | J Zoe Landens Jeannette N Williams Graeme R Jones | 2002 | J Clin M icrobiol2002，40，： | 1 |
| 10 | Synthesis of tungsten ditelluride thin films and highly crystalline nanobelts from pre-deposited reactants显示文摘Tungsten ditelluride(WTe_(2))is a layered transition metal dichalcogenide(TMD)that has attracted increasing research inter-est in recent years.WTe_(2) has demonstrated large non-saturating magnetoresistance,potential for spintronic applications and promise as a type-II Weyl semimetal.The majority of works on WTe_(2) have relied on mechanically exfoliated flakes from chemical vapour transport(CVT)-grown crystals for their investigations.While producing high-quality samples,this method is hindered by several disadvantages including long synthesis time,high-temperature annealing and an inherent lack of scalability.In this work,a synthesis method is demonstrated that allows the production of large-area polycrystalline films of WTe_(2).This is achieved by the reaction of pre-deposited films of W and Te at a relatively low temperature of 550℃.Sputter X-ray photoelectron spectroscopy reveals the rapid but self-limiting nature of the oxidation of these WTe_(2) films in ambient conditions.The WTe_(2) films are composed of areas of micrometre-sized nanobelts that can be isolated and offer potential as an alternative to CVT-grown samples.These nanobelts are highly crystalline with low defect densities indicated by transmission electron microscopy and show promising initial electrical results. | John B.Mc Manus Cansu Ilhan Bastien Balsamo Clive Downing Conor P.Cullen Tanja Stimpel‑Lindner Graeme Cunningham Lisanne Peters Lewys Jones Daragh Mullarkey Igor V.Shvets Georg S.Duesberg Niall McEvoy | 2020 | Tungsten2020，2，3： | 1 |
| 11 | Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis显示文摘 | Stuart F. W. Kendrick Graeme O’Boyle Jelena Mann Mujdat Zeybel Jeremy Palmer David E. J. Jones Chris P. Day | 2010 | Hepatology2010，，6： | 1 |
| 12 | 关节痛的内在体质及其他关健因素显示文摘关节炎是一种常见病。具有超过150种亚型。其中最为常见的是骨关节炎和风湿性关节炎。除此之外,还有脊柱关节病、痛风以及银屑病关节炎等亚型。疼痛是关节炎患者就诊的首要原因,它会导致患者日常功能障碍,严重影响生活质量。然而,目前时于关节炎并没有较好的治疗手段,治疗效果距离患者的期望值仍相去甚远。 | Graeme Jones 郑杰 赵华 | 2016 | 中国疼痛医学杂志2016，22，4： | 0 |
| 13 | Femoro Patella Vialla patellofemoral arthroplasty: An independent assessment of outcomes at minimum 2-year follow-up显示文摘AIM: To determine outcomes using the Femoro-Patella Vialla(FPV) arthroplasty and if there is an ideal patient for this implant. METHODS: A total of 41 FPV patellofemoral joint replacements were performed in 31 patients(22 females, 9 males, mean age 65 years). Mean followup was 3.2 years(minimum 2 years). Radiographs were reviewed preoperatively and postoperatively. We assessed whether gender, age, previous surgery, patella atla or trochlear dysplasia influenced patient satisfaction or patient functional outcome.RESULTS: The median Oxford Knee Score was 40 and the median Melbourne Patellofemoral Score was 21 postoperatively. Seventy-six percent of patients were satisfied, 10% unsure and 14% dissatisfied postoperatively. There was no radiological progression of tibiofemoral joint arthritis, using the Ahlback grading,in any patient. One patient, who was diagnosed with rheumatoid arthritis postoperatively, underwent revision to total knee replacement. There were no intraoperative lateral releases and no implant failures. Gender, age, the presence of trochlear dysplasia, patella alta or bilateral surgery did not influence patient outcome. Previous surgery did not correlate with outcome. CONCLUSION: In contrast to the current literature, the FPV shows promising early results. However, we cannot identify a subgroup of patients with superior outcomes. | Mansur Halai Andrew Ker Iain Anthony Graeme Holt Bryn Jones Mark Blyth | 2016 | World Journal of Orthopedics2016，7，8： | 0 |
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