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| 1 | Should dopamine be the first line inotrope in the treatment of neonatal hypotension? Review of the evidence显示文摘AIM: To determine if dopamine is effective in treating neonatal hypotension and safe to use comparing to other inotropes. METHODS: This is a review of evidence on inotropic treatment of neonatal hypotension. Databases searched were MEDLINE and the Cochrane Library, a total of 134 studies were identified. Only studies with high quality evidence(level 1a and b and 2a) were included. After review, only eight studies were included in the final analysis. Pooled risk ratios derived for each outcome [Mantel-Haenzel(M-H) fixed effect] with CI, as reported in the Cochrane reviews were plotted in forest plot form. RESULTS: Eight articles met inclusion criteria, which all included treatment in preterm infants. Dopamine increased mean arterial blood pressure(BP)(n = 163; r = 0.88, 95%CI: 0.76 to 0.94) and systolic BP(n = 142; r = 0.81, 95%CI: 0.42 to 0.94) comparing to placebo. Dopamine has been shown overall to be statistically more effective in increasing BP than dobutamine(n = 251, r = 0.26, 95%CI: 0.20-0.32). However there were no differences in short term outcomes(periventricular leucomalacia, periventricular haemorrhage) and mortality between both drugs. There is no statistical evidence of dopamine being more effective than adrenaline or corticosteroids. There was no difference in morbidity and mortality outcomes when dopamine was compared to hydrocortisone(RR 1.81, 95%CI: 0.18 to 18.39) or adrenaline. CONCLUSION: In preterms, dopamine is the most studied drug, and we suggest it could be used as first line treatment in hypotension. | Sadaf I Bhayat Harsha MS Gowda Michael Eisenhut | 2016 | World Journal of Clinical Pediatrics2016，5，2： | 3 |
| 2 | Acquirement of rituximab resistance in lymphoma cell lines is associated with both global CD20 gene and protein down-regulation regulated at the pretranscriptional and posttranscriptional levels显示文摘 | Czuczman MS Olejniczak S Gowda A | 2008 | Clin Cancer Res2008，14，5： | 1 |
| 3 | Variability of indices of hypoxemia in adult respiratory distress syndrome显示文摘 | Gowda MS Klocke RA | 1997 | Crit Care Med1997，25，： | 1 |
| 4 | Variability of indices of hypoxemia in adult respiratory distress syndrome 显示文摘 | Gowda MS Klocke RA | 1997 | Crit Care Med1997，25，1： | 1 |
| 5 | Complementary roles of color-flow duplex imaging and intravaseular ultrasound in the diagnosis of renal artery fibromuscular dysplasia: should renal arteriography serve as the 'gold standard'? 显示文摘 | Gowda MS Loeb AL Crouse LJ | 2003 | J Am Coll Cardiol2003，41，： | 1 |
| 6 | Variability of indices of hypoxemia in adult respiratory distress syndrome 显示文摘 | Gowda MS Klocke RA | 1997 | Crit Care Med1997，25，1： | 1 |
| 7 | Acquirement of rituximab resistance in lymphoma cell lines is associated with both global CD20 gene and protein down-regulation regulated at the pretranscriptional and posttranscriptional levels 显示文摘 | Czuczman MS Olejniczak S Gowda A | 2008 | Clin Cancer Res2008，14，5： | 1 |
| 8 | Complementary roles of color-flow duplex imaging and intravascular ultrasound in the diagnosis of renal artery fibromuscular dysplasia:should renal arteriography serve as the 'gold standard'显示文摘 | Gowda MS Loeb AL Crouse LJ | 2003 | J Am Coll Cardiol2003，41，8： | 1 |
| 9 | Early rehabilitation after surgery program versus conventional care during perioperative period in patients undergoing laparoseopic assisted total gastreetomy显示文摘 | Sahoo MR Gowda MS Kumar AT | 2014 | J Minim Access Surg2014，10，3： | 1 |
| 10 | Variability of indices of hypoxemia in adult respiratory distress syndrome显示文摘 | Gowda MS Klocke RA | 1997 | Crit Care Med1997，25，1： | 1 |
| 11 | Variability of indices of hypoxemia in adult respiratory distress syndrome 显示文摘 | Gowda MS Klocke RA | 1997 | Crit Care Med1997，25，： | 1 |
| 12 | Variaability of incidence of hypoxemia in adult resopiratory distress syndrome显示文摘 | Gowda MS Klocke RA | 1997 | Crit Care Med1997，25，1： | 1 |
| 13 | Death certificate completion: how well are physicians trained and are cardiovascular causes overstated显示文摘 | Lakkireddy DR Gowda MS Murray CW | 2004 | Am J Med2004，117，： | 1 |
| 14 | Acquirement of rituximab resistance in lymphoma cell lines is associated with both global CD20 gene and protein down-regulation regulated at the pretranscriptional and posttranscriptional levels 显示文摘 | Czuczman MS Olejniczak S Gowda A | 2008 | Clin Cancer Res2008，14，5： | 1 |
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