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| 1 | A phase Ⅱ study of gemcitabine and carboplatin combination chemotherapy in gallbladder carcinoma显示文摘BACKGROUND: Patients with carcinoma of the gallbladder have advanced, unresectable tumor at the time of presentation and face a dismal prognosis in the absence of a standard palliative chemotherapy regimen. This study was undertaken to evaluate the efficacy and safety of combined chemotherapy of gemcitabine and carboplatin in 20 patients with advanced gallbladder carcinoma. METHODS: The criteria of eligibility included chemonaive patients with unresectable gallbladder cancer, bidimensionaIly measurable disease, Zubrod’s performance status≤2, and adequate major organ function. The patients received gemcitabine (1000 mg/m^2) on days 1 and 8, and carboplatin (target AUC of 5.0 mg/ml) on day 1, in a 21-day cycle. CT was used for response assessment. RESULTS: In this group of 20 patients with advanced gallbladder carcinoma 6 were men and 14 women, with a median age of 55 years. The stage of the tumor at presentation was IVB in 14 patients (70%), IVA in 3 (15%) and Ⅲ in 3 (15%). Four patients (21%) achieved a complete response, and 3 (15.7%), a partial response; an overall response rate was 36.7%. The median time to progression of the tumor was 33.8 weeks, and 1-year survival rate of the patients was 43.3%. Anemia of WHO grade Ⅲ or Ⅳ was seen in 2 patients (10%) and 1 patient (5%), respectively. Grade Ⅲ neutropenia and thrombocytopenia were observed in 2 patients (10%) and 1 patient (5%), respectively. CONCLUSION: With mild toxicity, combined chemotherapy of gemcitabine and carhoplatin is effective in the treatment of advanced gallbladder carcinoma. | Pramod Kumar Julka Tarun Puri Goura Kishore Rath | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，1： | 7 |
| 2 | 黄斑色素与黄斑区视锥细胞功能相互关系的临床观察显示文摘目的 探讨黄斑色素 (macular pigment,MP)与黄斑区视锥细胞功能的相互关系。 方法 对临床确诊的 16例 Stargardt患者的 32只眼 ,3例黄斑裂孔患者的 3只眼用激光扫描检眼镜 (scanninglaserophthalmoscope,SL O)进行黄斑区 MP密度的检测。通过 SL O的氩激光蓝色及红外波段进行 MP的诊断与密度分级。用自编的计算机 C+ + 程序进行 MP密度评估 ,并将 MP分为完整 MP、部分 MP及 MP缺失 3级。对比分析 MP分级与 Snellen视力检查结果的相互关系。 结果 视力低于 2 0 / 2 0 0的 13只眼全部表现为 MP缺失 ;视力等于或高于 2 0 / 4 0的 11只中 10只眼表现为完整 MP,1只眼表现为部分 MP;视力介于两者之间的 11只眼表现为部分 MP。检测结果无病种间的差别。 结论 MP与患者的视力密切相关 ,是黄斑区视锥细胞功能完整的标志。 | 张新媛 Stanley Chang Gaetano Barile Peter Gouras | 2003 | 中华眼底病杂志2003，19，4： | 4 |
| 3 | Primary pediatric mid-brain lymphoma:Report of a rare pediatric tumor in a rare location显示文摘Primary central nervous system lymphoma(PCNSL) is a rare disease in pediatric age group. A thirteen-yearold male child presented with complaints of headache for six months, vomiting and diplopia for three days. Magnetic resonance imaging of the brain showed a single lesion of 1.7 cm × 1.6 cm × 1.6 cm in the mid brain and tectum. He underwent a gross total resection of the tumor. The histopathological evaluation revealed B cell high grade non Hodgkin lymphoma. The patient was treated with High dose methotrexate and cranio spinal radiation. The patient was alive without disease 12 mo after completion of treatment. This case highlights importance of keeping PCNSL as differential in brain stem lesions of pediatric patients also. Radiation and chemotherapy remains the most important treatment for such patients. | Rony Benson Supriya Mallick Suvendu Purkait Vaishali Suri K P Haresh Subhash Gupta Dayanand Sharma Pramod Kumar Julka Goura Kishore Rath | 2016 | World Journal of Clinical Cases2016，4，12： | 2 |
| 4 | Transplantation of retinal cells显示文摘 | Gouras P Lopez R Du J | 1990 | Neuro Ophthalmol1990，10，： | 1 |
| 5 | Revisiting the Role of Computerized Tomographic Scan and Cystoscopy for Detecting Bladder Invasion in the Revised FIGO Staging System for Carcinoma of the Uterine Cervix显示文摘 | Daya Nand Sharma Sanjay Thulkar Shikha Goyal Nootan Kumar Shukla Sunesh Kumar Goura Kisor Rath Parmod Kumar Julka Gagan Saini Amit Bahl | 2010 | International Journal of Gynecological Cancer2010，，3： | 1 |
| 6 | Growth characteristics and ultrastructure of human retinal pigment epithelium in vitro 显示文摘 | Flood MT Gouras P Kjeldbye H | 1980 | Invest Ophthalmol Vis Sci1980，19，： | 1 |
| 7 | The function of the midget cell system in primate color vision显示文摘 | Gouras P | 1971 | Vision Res1971，，3： | 1 |
| 8 | Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy显示文摘 | Bennett J Tanabe T Sun D Zeng Y Kieldbye H Gouras P | 1996 | Nat Med1996，2，6： | 1 |
| 9 | Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides显示文摘 | Greenfield JP Tsai J Gouras GK | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 10 | Cellular and molecular basis of beta-amyloid precursor protein metabolism显示文摘 | Greenfield J P Gross R S Gouras G K | 2000 | Front Biosci2000，5，： | 1 |
| 11 | Transplantation of fetal retinal pigment epithelium in age-related macular degeneration with subfoveal neovascularization显示文摘 | Algvere PV Berglin L Gouras P | 1994 | Graefer s Arch Clin Exp Ophthalmol1994，232，12： | 1 |
| 12 | Transplantation of RPE in age-related macular degeneration:observations in disciform lesions and dry RPE atrophy显示文摘 | Algvere PV Berglin L Gouras P | 1997 | Graefer s Arch Clin Exp Ophthalmol1997，235，3： | 1 |
| 13 | Patch culturing and transfer of human fetal retinal epithelium显示文摘 | Gouras P Cao H Sheng Y | 1994 | Graefe''s Arch Clin Exp Ophthalmol1994，232，10： | 1 |
| 14 | Intraneuronal Abeta accumulation and origin of plaques in Alzheimer′s disease显示文摘 | Gouras GK Almeida CG Takahashi RH | 2005 | Neurobiol Aging2005，26，9： | 1 |
| 15 | A data exchange method for fluid- structure interaction problems显示文摘 | Goura G S L Badcock K J | 2001 | The Aeronautical Journal2001，105，： | 1 |
| 16 | Neurogenesis as a therapeutic strategy for cognitive ag- ing and Alzheimer's disease显示文摘 | Gouras G Fillit H | 2006 | Curt Alzheimer Res2006，3，1： | 1 |
| 17 | Transplantation of RPE in age-related macular degeneration:observations in disciform lesions and dry RPE atrophy显示文摘 | Algvere PV Berglin L Gouras P | 1997 | Graefe''s Arch Clin Exp Ophthalmol1997，235，3： | 1 |
| 18 | Transplantation of RPE in age- related macular degeneration : observations in disciform lesions and dry RPE atrophy 显示文摘 | Algvere PV Berglin L Gouras P | 1997 | Graefe'' s Arch Clin Exp Ophthalmol1997，235，： | 1 |
| 19 | A novel melano-lysosome in the retinal epithelium of rhesus monkeys显示文摘 | Gouras P Brown K Ivert L | 2011 | Exp Eye Res2011，93，6： | 1 |
| 20 | Transplantation of RPE in age-related macular degeneration: observations in disciform lesions and dry RPE atrophy 显示文摘 | Algvere PV Berglin L Gouras P Sheng Y | 1997 | Graefe Arch Clin Exp Ophthalmol1997，235，： | 1 |
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