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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Recognising Structure in Laser Scanner Point Clouds显示文摘 | VOSSELMAN G GORE B G H SITHOLE G et a1 | 2004 | The International Archives of Photogrammetry RemoteSensing and Spatial Information Sciences2004，46，8： | 1 |
| 3 | Cholangiocarcinoma: modern advances in understanding a deadly old disease 显示文摘 | Malhi H Gores GJ | 2006 | J Hepatol2006，45，6： | 1 |
| 4 | HAZEXPERT: an integrated expert system to support hazard analysis in process plant design 显示文摘 | Goring M Schecker H G | 1993 | Computers &Chemical Engineering1993，17，： | 1 |
| 5 | Recognising Structure in Laser Scanner Point Clouds, International Archives of Photogrammetry显示文摘 | Vosselman G Gore B G H Sithole G | 2004 | Remote Sensing and Spatial Information Sciences2004，46，82： | 1 |
| 6 | Mechanisms of hepatotox- icity 显示文摘 | Jaeschke H Gores GJ Cederbatlm AI | 2002 | Toxicol Sci2002，65，： | 1 |
| 7 | A new class of electrochemically and thermally stable lithium salts for lithium battery electrolytes显示文摘 | Barthel J Schmid A Gores H J | 2000 | J Electrochem Soc2000，147，1： | 1 |
| 8 | Spatio-temporal Data Types: An Approach to Modeling and Querying Moving Objects in Databases显示文摘 | Erwig M GOring R H Schneider M et el | 1999 | GeoInformatica1999，3，3： | 1 |
| 9 | Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease显示文摘 | Malhi H Gores GJ | 2008 | Semin Liver Dis2008，28，4： | 1 |
| 10 | Apoptosis and necrosis in the liv- er: a tale of two deaths 显示文摘 | Malhi H Gores GJ Lemasters JJ | 2006 | Hepatology2006，43，21： | 1 |
| 11 | The modern diagnosis and therapy of cholan- giocarcinoma显示文摘 | Malhi H Gores GJ | 2006 | Aliment Pharmacol Ther2006，23，： | 1 |
| 12 | Hepatocyte death: a clear and present danger显示文摘 | Malhi H Guicciardi ME Gores GJ | 2010 | Physiol Rev2010，90，3： | 1 |
| 13 | Long term survival following partial vs radical ne- phrectomy among older patients with early-stage kid ney cancer显示文摘 | Tan H J Norton E C Ye Z Hafez K S Gore J L Miller D C | 2012 | JAMA2012，307，： | 1 |
| 14 | Cultivation and characterization of limbal epithelial stem cells on contact lenses with a feeder layer: toward the treatment of limbal stem cell deficiency显示文摘 | Gore A Horwitz V Gutman H | 2014 | Cornea2014，33，1： | 1 |
| 15 | Prospective, randomized, controlled pilot study of partial liquid ventilation in adult acute respiratory distress syndrome显示文摘 | Croce M Gore D Wiedemann H | 2002 | Am J Respir Crit Care Med2002，165，6： | 1 |
| 16 | Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease显示文摘 | Malhi H Gores GJ | 2008 | Svmin Liver Dis2008，28，： | 1 |
| 17 | microRNA-10b enhances pancre- atic cancer cell invasion by suppressing TIP30 expression and promo- ting EGF and TGF-β actions显示文摘 | Ouyang H Gore J Deitz S | 2013 | Oncogene2013，，： | 1 |
| 18 | A Spectral Deciphering the Perturbation of Model Transporter Protein (HSA) by Antibacterial Pyrimidine Derivative : Pharmacokinetic and Biophysical Insights 显示文摘 | Suryawanshi V D Anbhule P V Gore A H | 2013 | J Photochem Photobiol B2013，118，： | 1 |
| 19 | High-temperature mechanical behavior and hot rolling of AA705X显示文摘 | HARNISH S F PADILLA H A DANTZIG J A BEAUDOIN A J GORE B E ROBERTSON I M | 2005 | Metallurgical and Materials Transactions A2005，36，： | 1 |
| 20 | Review article:the modern diagnosis and therapy of cholangiocarcinoma显示文摘 | Malhi H Gores GJ | 2006 | Aliment Pharmacol Ther2006，23，9： | 1 |
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