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| 1 | Metformin does not improve survival in patients with hepatocellular carcinoma显示文摘AIM:To assess whether metformin,which has a chemopreventive effect in chronic liver disease,has any chemotherapeutic effect in hepatocellular carcinoma.METHODS:This was a retrospective study of 701 patients with newly diagnosed hepatocellular carcinoma(HCC)seen between January 2005 and June 2011 at Mayo Clinic,Rochester,Minnesota.This patient cohort was a part of the global HCC BRIDGE study,which is a large longitudinal study of HCC determining the realworld experience of HCC characteristics,management and patient outcomes.We defined significant metformin exposure as continuation of this agent at least 90d beyond diagnosis of HCC,and compared survival of diabetic patients on metformin to diabetic patients not on metformin and non-diabetics.RESULTS:Our cohort was 72.9%male,with a mean±SD age of 62.6±12.3 years.The most common etiologies of liver disease were hepatitis C(34%),alcoholic liver disease(29%),fatty liver disease(15%)and hepatitis B(9%).By univariate analysis,using diabetics not on metformin as the reference group,diabetic patients with HCC on metformin had no survival advantage,with a HR(95%CI)of 1.0(0.8-1.3).Non-diabetic HCC patients also did not appear to have a survival advantage as compared to diabetic HCC patients not on metformin,as demonstrated by a HR(95%CI)of1.1(0.7-1.7).Diabetics on metformin beyond 90 d after HCC diagnosis had a longer median survival at 34.2 mo,as compared to 25.5 mo among diabetic patients who were not on metformin or had discontinued metformin within 90 d after HCC diagnosis.This finding was likely due to potential survival bias among those who lived long enough to receive metformin.CONCLUSION:Although the literature suggests a chemotherapeutic effect in other malignancies,our study demonstrates no survival benefit to the use of metformin in diabetic patients with HCC. | Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck Ju Dong Yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts | 2014 | World Journal of Gastroenterology2014，20，42： | 11 |
| 2 | Clinical significance of mesenteric panniculitis-like abnormalities on abdominal computerized tomography in patients with malignant neoplasms显示文摘AIM To clarify the association of malignancy with mesenteric panniculitis-like changes on computed tomography(CT).METHODS All abdominal CT scans performed at North Shore University HealthS ystem showing mesenteric panniculitis from January 2005 to August 2010 were identified in the Radnet(Rad Net Corporation, Los Angeles, CA) database. Patients with a new or known diagnosis of a malignancy were included for this analysis. Longitudinal clinical histories were obtained from electronic medical records.RESULTS In total, 147794 abdominal CT scans were performed during the study period. Three hundred and fiftynine patients had mesenteric panniculitis(MP)-like abnormalities on their abdominal CT. Of these patients, 81 patients(22.6%) had a known history of cancer at the time of their CT scan. Nineteen(5.3%) had a new diagnosis of cancer in concurrence with their CT, but the majority of these(14/19, 74%) were undergoing CT as part of a malignancy evaluation. Lymphomas were the most common cancers associated with MPlike findings on CT(36 cases, 36%), with follicular lymphoma being the most frequent subtype(17/36). A variety of solid tumors, most commonly prostate(7) and renal cell cancers(6) also were seen. CT follow up was obtained in 56 patients. Findings in the mesentery were unchanged in 45(80%), worsened in 6(11%), and improved in 5 patients(9%). Positron emission tomography(PET) scans performed in 44 patients only showed a positive uptake in the mesenteric mass in 2 patients(5%). CONCLUSION A new diagnosis of cancer is uncommon in patients with CT findings suggestive of MP. MP-like mesenteric abnormalities on CT generally remain stable in patients with associated malignancies. PET scanning is not recommended in the evaluation of patients with mesenteric panniculitis-like findings on CT. | Eli D Ehrenpreis Grigory Roginsky Richard M Gore | 2016 | World Journal of Gastroenterology2016，22，48： | 7 |
| 3 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 4 | Synthesis of putative intermediates in the biosynthesis of the kinamycin antibiotics: total synthesis of phenanthroviridn aglycon and related compounds显示文摘 | GORE M P GOULD S J WELLER D D | 1992 | J Org Chem1992，57，： | 2 |
| 5 | Reagentless pH - based biosensing using a fluorescently - labelled dextran coentrapped with a hydrolytic enzyme in solgel derived nanocomposite films显示文摘 | GULCEV M D GORING L G GILLIAN R M | 2002 | Anal Chim Acta2002，457，1： | 1 |
| 6 | Comments on' On the connectivity in finite Ad Hoc networks' 显示文摘 | Gore A D | 2006 | IEEE Commun Lett2006，10，2： | 1 |
| 7 | Burnout in sport:a systematic review显示文摘 | Goodger K Gorely T Lavallee D | | 0，，： | 1 |
| 8 | The flatness of lignosulfonate macromolecules as demonstrated by elec- tron microscopy 显示文摘 | Goring D A I Vuong R Gancet C | 1979 | Journal of Applied Polymer Sci- ence1979，24，4： | 1 |
| 9 | Flow turbulence over fixed and weakly mobile gravel beds 显示文摘 | Nikora V Goring D | 2000 | Journal of Hydraulic Engineering2000，126，9： | 1 |
| 10 | Correction to ' Comments on'On the connectivity in finite Ad Hoc networks'' 显示文摘 | Gore A D | 2006 | IEEE Commun Lett2006，0，5： | 1 |
| 11 | The effect of humidity on the curing of 3-glycidoxypropyltrimethoxy silane (GPS) 显示文摘 | Underhill P R Goring G DuQuesnay D L | 2000 | International Journal of Adhesion Adhesive2000，20，3： | 1 |
| 12 | Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S-locus receptor kinase 显示文摘 | Bower M S Matias D D Femandes-carvalho E Mazzurco M Gu T Rothstein A J and Goring D R | 1996 | Plant Cell1996，8，： | 1 |
| 13 | Burnout insport: A systematic review 显示文摘 | GOODGER K GORELY T LAVALLEE D | 2007 | Sport Psychol2007，21，： | 1 |
| 14 | Prospective,randomized,controlledpilots study of partial liquid ventilation in adult acute respiratory distresssyndrome显示文摘 | HirschlDB Croce M Gore D | 2002 | Am J Respir Crit Care Med2002，165，： | 1 |
| 15 | Polyelectrolyte expansion of a lignin sulfonate microgel显示文摘 | REZANOWICH A GORING D A I | | 0，，05： | 1 |
| 16 | Despiking acoustic Doppler velocimeter data 显示文摘 | Goring D G Nikora V I | 2002 | Journal of Hydraulic Engineering2002，128，1： | 1 |
| 17 | Association of hyperglycemia with increased mortality after severe bum injury 显示文摘 | Gore DC Chinkes D Heggers J | 2001 | J Trauma2001，51，3： | 1 |
| 18 | Use of Sertoli Cell Transplants to Provide Local Immunoprotection for Tissue Grafts显示文摘 | Halberstadt C Emerich D F Gores P | 2004 | Expert Opin Biol Ther2004，4，6： | 1 |
| 19 | Structure and radiation properties of large-scale natural gas/air diffusion flames显示文摘 | GORE J P FAETH G M EVANS D | 1986 | Fire and Materials1986，10，34： | 1 |
| 20 | Burnout in sport: A systematic review显示文摘 | GOODGER K GORELY T LAVALLEE D | 2007 | Sport Psychologist2007，21，： | 1 |
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