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| 1 | Phase angle obtained by bioelectrical impedance analysis independently predicts mortality in patients with cirrhosis显示文摘AIM To evaluate the prognostic value of the phase angle(PA)obtained from bioelectrical impedance analysis(BIA) for mortality prediction in patients with cirrhosis. METHODS In total, 134 male cirrhotic patients prospectively completed clinical evaluations and nutritional assessment by BIA to obtain PAs during a 36-mo follow-up period. Mortality risk was analyzed by applying the PA cutoff point recently proposed as a malnutrition marker(PA ≤ 4.9°) in Kaplan-Meier curves and multivariate Cox regression models. RESULTS The patients were divided into two groups according to the PA cutoff value(PA > 4.9°, n = 73; PA ≤ 4.9°, n = 61). Weight, height, and body mass index were similar in both groups, but patients with PAs > 4.9° were younger and had higher mid-arm muscle circumference, albumin, and handgrip-strength values and lower severe ascites and encephalopathy incidences, interleukin(IL)-6/IL-10 ratios and C-reactive protein levels than did patients with PAs ≤ 4.9°(P ≤ 0.05). Forty-eight(35.80%) patients died due to cirrhosis, with a median of 18 mo(interquartile range, 3.3-25.6 mo) follow-up until death. Thirty-one(64.60%) of these patients were from the PA ≤ 4.9° group. PA ≤ 4.9° significantly and independently affected the mortality model adjusted for Model for End-Stage Liver Disease score and age(hazard ratio = 2.05, 95%CI: 1.11-3.77, P = 0.021). In addition, Kaplan-Meier curves showed that patients with PAs ≤ 4.9° were significantly more likely to die. CONCLUSION In male patients with cirrhosis, the PA ≤ 4.9° cutoff was associated independently with mortality and identified patients with worse metabolic, nutritional, and disease progression profiles. The PA may be a useful and reliable bedside tool to evaluate prognosis in cirrhosis. | Giliane Belarmino Maria Cristina Gonzalez Raquel S Torrinhas Priscila Sala Wellington Andraus Luiz Augusto Carneiro D'Albuquerque Rosa Maria R Pereira Valéria F Caparbo Graziela R Ravacci Lucas Damiani Steven B Heymsfield Dan L Waitzberg | 2017 | World Journal of Hepatology2017，9，7： | 11 |
| 2 | Current protective strategies in liver surgery显示文摘During liver resection surgery for cancer or liver transplantation,the liver is subject to ischaemia (reduction in blood flow) followed by reperfusion (restoration of blood flow),which results in liver injury [ischemiareperfusion (IR) or IR injury]. Modulation of IR injury can be achieved in various ways. These include hypothermia,ischaemic preconditioning (IPC) (brief cycles of ischaemia followed by reperfusion of the organ before the prolonged period of ischaemia i.e. a conditioning response),ischaemic postconditioning (conditioning after the prolonged period of ischaemia but before the reperfusion),pharmacological agents to decrease IR injury,genetic modulation of IR injury,and machine perfusion (pulsatile perfusion). Hypothermia decreases the metabolic functions and the oxygen consumption of organs. Static cold storage in University of Wisconsin solution reduces IR injury and has prolonged organ storage and improved the function of transplanted grafts. There is currently no evidence for any clinical advantage in the use of alternate solutions for static cold storage. Although experimental data from animal models suggest that IPC,ischaemic postconditioning,various pharma-cological agents,gene therapy,and machine perfusion decrease IR injury,none of these interventions can be recommended in clinical practice. This is because of the lack of randomized controlled trials assessing the safety and efficacy of ischaemic postconditioning,gene therapy,and machine perfusion. Randomized controlled trials and systematic reviews of randomized controlled trials assessing the safety and efficacy of IPC and various pharmacological agents have demonstrated biochemical or histological improvements but this has not translated to clinical benefit. Further well designed randomized controlled trials are necessary to assess the various new protective strategies in liver resection. | Kurinchi S Gurusamy Hector D Gonzalez Brian R Davidson | 2010 | World Journal of Gastroenterology2010，16，48： | 7 |
| 3 | Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections显示文摘Selection of the appropriate donor is essential to a successful allograft recipient outcome for solid organ transplantation. Multiple infectious diseases have been transmitted from the donor to the recipient via transplantation. Donor-transmitted infections cause increased morbidity and mortality to the recipient. In recent years, a series of high-profile transmissions of infections have occurred in organ recipients prompt-ing increased attention on the process of improving the selection of an appropriate donor that balances the shortage of needed allografts with an approach that mitigates the risk of donor-transmitted infection to the recipient. Important advances focused on improving donor screening diagnostics, using previously excluded high-risk donors, and individualizing the selection of allografts to recipients based on their prior infection history are serving to increase the donor pool and improve outcomes after transplant. This article serves to review the relevant literature surrounding this topic and to provide a suggested approach to the selection of an appropriate solid organ transplant donor. | Christopher S Kovacs Jr Christine E Koval David van Duin Amanda Guedes de Morais Blanca E Gonzalez Robin K Avery Steven D Mawhorter Kyle D Brizendine Eric D Cober Cyndee Miranda Rabin K Shrestha Lucileia Teixeira Sherif B Mossad | 2014 | World Journal of Transplantation2014，4，2： | 7 |
| 4 | The natural history of Ebola virus in Africa显示文摘 | Xavier Pourrut Brice Kumulungui Tatiana Wittmann Ghislain Moussavou André Délicat Philippe Yaba Dieudonné Nkoghe Jean-Paul Gonzalez Eric Maurice Leroy | 2005 | Microbes and Infection2005，，7： | 4 |
| 5 | Ribosomal DNA restriction fragment length polymorphism in Rhizoctonia solani 显示文摘 | VILGALYS R GONZALEZ D | 1990 | Phytopathology1990，80，： | 2 |
| 6 | Role of endoscopic ultrasound in the screening and follow-up of high-risk individuals for familial pancreatic cancer显示文摘Managing familial pancreatic cancer(FPC)is challenging for gastroenterologists,surgeons and oncologists.High-risk individuals(HRI)for pancreatic cancer(PC)(FPC or with germline mutations)are a heterogeneous group of subjects with a theoretical lifetime cumulative risk of PC over 5%.Screening is mainly based on annual magnetic resonance imaging(MRI)and endoscopic ultrasound(EUS).The goal of screening is to identify early-stage operable cancers or high-risk precancerous lesions(pancreatic intraepithelial neoplasia or intraductal papillary mucinous neoplasms with high-grade dysplasia).In the literature,target lesions are identified in 2%-5%of HRI who undergo screening.EUS appears to provide better identification of small solid lesions(0%-46%of HRI)and chronicpancreatitis-like parenchymal changes(14%-77%of HRI),while MRI is probably the best modality to identify small cystic lesions(13%-49%of HRI).There are no specific studies in HRI on the use of contrast-enhanced harmonic EUS.EUS can also be used to obtain tissue samples.Nevertheless,there is still limited evidence on the accuracy of imaging procedures used for screening or agreement on which patients to treat.The cost-effectiveness of screening is also unclear.Certain new EUS-related techniques,such as searching for DNA abnormalities or protein markers in pancreatic fluid,appear to be promising. | Diane Lorenzo Vinciane Rebours Frédérique Maire Maxime Palazzo Jean-Michel Gonzalez Marie-Pierre Vullierme Alain Aubert Pascal Hammel Philippe Lévy Louis de Mestier | 2019 | World Journal of Gastroenterology2019，25，34： | 2 |
| 7 | Membrane redistributions through multi-intercellular exchanges and serial trogocytosis显示文摘Trogocytosis 是在膜的房间之间的快速的转移并且联系蛋白质。Trogocytic 交换在不同房间类型之间被调查了,主要在二房间的系统,包含一个施主和一种领受人房间类型。这里,我们在一个更复杂的系统学习了 trogocytosis,包含不仅几个有免疫力的房间子集而且多重肿瘤房间。我们证明 CD4+ T 房间, CD8+ T 房间和单核白血球能获得膜补丁和他们由多重同时的 trogocytoses 从不同肿瘤房间包含的未经触动的蛋白质。CD4+ 和 CD8+ T 房间的 trogocytic 能力被发现类似于自体同源的单核白血球的,却劣等。激活的外部血的 mononuclear 房间(PBMC ) 可以也在一个所有自体同源的系统交换在自己之间的膜。为这个原因,单核白血球能够从多重肿瘤房间来源获得膜,并且再把他们转移到自体同源的 T 房间,与一些他们的自己的膜(连续 trogocytosis ) 一起。我们的数据说明在自体同源的激活的有免疫力的受动器房间和他们的环境之间的膜交换的程度,并且包括鈥渂y stander 鈥 ? 房间,本地环境的细胞的内容怎么可以影响有免疫力的受动器房间的功能。 | Estlbahz Alegre Klave-Yune HoWangYin Benolt Favier Jeremy Baudhuin Emilie Lesport Marina Daouya Alvaro Gonzalez Edgardo D Carosella Joel LeMaoult | 2010 | Cell Research2010，20，11： | 2 |
| 8 | G-protein β3 subunit gene variant and left ventricular hypertrophy in essential hypertension显示文摘 | POCH E GONZALEZ D GOMEZ-ANGELATS E | 2000 | Hypertension2000，3512，： | 1 |
| 9 | Nitric-oxide-directed synaptie remodeling in the adult mamml CNS 显示文摘 | Sunieo C R Portillo F Gonzalez Forero D | 2005 | Neuroscience2005，25，6： | 1 |
| 10 | Tension versus compression superplastic behavior of a Mg-29wt% Li-25wt%B4C composite显示文摘 | WOLFENSTINE J GONZALEZ - DONGE G SHERBY O D | 1992 | Materials Letters1992，15，4： | 1 |
| 11 | improved survival in patients with locally advanced prostate cancer treated with radiotherapy and goserelin 显示文摘 | Bolla M Gonzalez D Warde P | 1997 | N EngtJ Med1997，337，5： | 1 |
| 12 | Pluripotency of mesenchymal stem cells derived from adult marrow显示文摘 | Jiang Y Jahagirdar B N Reinhardt R L Schwartz R E Keene C D Ortiz Gonzalez X R | 2002 | Nature2002，418，： | 1 |
| 13 | The effect of coke deposition on the deactivation of sulfated zireonia catalysts 显示文摘 | LI Bing-hui GONZALEZ R D | 1997 | Applied Catalysis A: General1997，174，12： | 1 |
| 14 | The effect of grain size on the wear properties of electrodeposited nanocrystalline nickel coatings显示文摘 | Jeong D H Gonzalez F Palumbo G | 2001 | Seripta Mater2001，44，3： | 1 |
| 15 | Ethylene glycol monoe- thyl ether for determining surface area of silicate minerals 显示文摘 | Carter D L Heilman M D Gonzalez C L | 1965 | Soil Science1965，100，6： | 1 |
| 16 | Mechanical propertiesof ultrahigh boron steels显示文摘 | Jimenez J A Gonzalez D G Ruano O A | 1995 | Advanced Materials1995，7，2： | 1 |
| 17 | Breeding cycle of the northern scallop, Argopecten purpuratus (Lamarck, 1819) in southern Chile 显示文摘 | Gonzalez M L Perez M C Lopez D A | 2002 | Aquaculture Research2002，33，11： | 1 |
| 18 | The two-incision approach for video-assisted thoracoscopic lobectomy:an initial experience显示文摘 | Borro JM Gonzalez D Paradela M | 2011 | Eur J Cardiothorac Surg2011，39，1： | 1 |
| 19 | hnmobi- lization of candida rugosa lipase on bentonite modified with benzyhriethylammonium chloride 显示文摘 | RAMOS M D GOMEZ G I G GONZALEZ N S | 2014 | Journal of Molecular Catalysis B : Enzymatic2014，，99： | 1 |
| 20 | Activity of softening enzymes during cherry maturation显示文摘 | Barrett D M Gonzalez G | 2004 | Journal of Food Science2004，59，3： | 1 |
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