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| 1 | Computed tomography findings of pneumatosis and portomesenteric venous gas in acute bowel ischemia显示文摘AIM:To use more representative sample size to evaluate whether computed tomography(CT)scan evidence of the concomitant presence of pneumatosis and portomesenteric venous gas is a predictor of transmural bowel necrosis.METHODS:Data from 208 patients who were referred for a diagnosis of bowel ischemia were retrospectively reviewed.Only patients who underwent a surgical intervention following a diagnosis of bowel ischemia who also had a post-operative histological confirmation of such a diagnosis were included.Patients were split into two groups according to the presence of histological evidence of transmural bowel ischemia(case group)or partial bowel ischemia(control group).CT images were reviewed for findings of ischemia,including mural thickening,pneumatosis,bowel distension,portomesenteric venous gas and arterial or venous thrombi.RESULTS:A total of 248 subjects who underwent surgery for bowel ischemia were identified.Among the208 subjects enrolled in our study,transmural bowel necrosis was identified in 121 subjects(case group),and partial bowel necrosis was identified in 87 subjects(control group).Based on CT findings,including mural thickening,bowel distension,pneumatosis,pneumatosis plus portomesenteric venous gas and presence of thrombi or emboli,there were no significant differences between the case and control groups.The concomitant presence of pneumatosis and porto-mesenteric venous gas showed an odds ratio of 1.95(95%CI:0.491-7.775,P=0.342)for the presence of transmural necrosis.The presence of pneumatosis plus porto-mesenteric venous gas exhibited good specificity(83%)but low sensitivity(17%)in the identification of transmural bowel infarction.Accordingly,the positive and negative predictive values were 60% and 17%,respectively.CONCLUSION:Although pneumatosis plus porto-mesenteric venous gas is associated with bowel ischemia,we have demonstrated that their co-occurrence cannot be used as diagnostic signs of transmural necrosis. | Marco Milone Matteo Nicola Dario Di Minno Mario Musella Paola Maietta Vittorio Iaccarino Giovanni Barone Francesco Milone | 2013 | World Journal of Gastroenterology2013，19，39： | 15 |
| 2 | New fecal test for non-invasive Helicobacter pylori detection:A diagnostic accuracy study显示文摘AIM To assess the diagnostic accuracy of a new fecal test for detecting Helicobacter pylori(H. pylori), using ^(13)Curea breath test as the reference standard, and explore bacterial antibiotic resistance. METHODS We conducted a prospective two-center diagnostic test accuracy study. We enrolled consecutive people≥ 18 years without previous diagnosis of H. pylori infection, referred for dyspepsia between February and October 2017. At enrollment, all participants underwent 13 C-urea breath test. Participants aged over 50 years were scheduled to undergo upper endoscopy with histology. Participants collected stool samples 1-3 d after enrollment for a new fecal investigation(THD fecal test). The detection of bacterial 23 S rRNA subunit gene indicated H. pylori infection. We also used the index diagnostic test to examine mutations conferring resistance to clarithromycin and levofloxacin. Independent investigators analyzed index test and reference test standard results blinded to the other test findings. We estimated sensitivity, specificity, positive(PPV) and negative(NPV) predictive value, diagnostic accuracy, positive and negative likelihood ratio(LR), together with 95% confidence intervals(CI).RESULTS We enrolled 294 consecutive participants(age: Median 37.0 years, IQR: 29.0-46.0 years; men: 39.8%). Ninetyfive(32.3%) participants had a positive ^(13)C-urea breath test. Twenty-three(7.8%) participants underwent upper endoscopy with histology, with a full concordance between ^(13)C-urea breath test and histology in detecting H. pylori infection. Four(1.4%) out of the 294 participants withdrew from the study after the enrollment visit and did not undergo THD fecal testing. In the 290 participants who completed the study, the THD fecal test sensitivity was 90.2%(CI: 84.2%-96.3%), specificity 98.5%(CI:96.8%-100%), PPV 96.5%(CI: 92.6%-100%), NPV 95.6%(CI: 92.8%-98.4%), accuracy 95.9%(CI: 93.6%-98.2%), positive LR 59.5(CI: 19.3-183.4), negative LR 0.10(CI: 0.05-0.18). Out of 83 infected participants identified with the THD fecal test, 34(41.0%) had bacterial genotypic changes consistent with antibiotic-resistant H. pylori infection. Of these, 27(32.5%) had bacterial strains resistant to clarithromycin, 3(3.6%) to levofloxacin, and 4(4.8%) to both antibiotics. CONCLUSION The THD fecal test has high performance for the non-invasive diagnosis of H. pylori infection while additionally enabling the assessment of bacterial antibiotic resistances. | Andrea Iannone Floriana Giorgio Francesco Russo Giuseppe Riezzo Bruna Girardi Maria Pricci Suetonia C Palmer Michele Barone Mariabeatrice Principi Giovanni FM Strippoli Alfredo Di Leo Enzo Ierardi | 2018 | World Journal of Gastroenterology2018，24，27： | 5 |
| 3 | Decrease of serum carnitine levels in patients with or without gastrointestinal cancer cachexia显示文摘瞄准:在消化机关与癌症在病人评估浆液肉毒碱的层次并且把他们与另外的癌症作比较以便提供新卓见进极度瘦弱的机制。方法:55 个恶病质病人与或没有胃肠的癌症在现在的学习被注册。他们经历了平淡的实验室调查,包括在浆液在场的肉毒碱的各种各样的形式的层次的检查(即,长链的酰肉毒碱,短链的酰肉毒碱,免费肉毒碱,和全部的肉毒碱) 。这些价值与 30 个健康控制题目在好营养的地位以及与那些在 60 个癌症病人发现的那些相比。结果:当没有胃肠的癌症,有胃肠的癌症的恶病质病人与恶病质病人相比时,差别是在免费肉毒碱的 -6.8 micromol/L (P <
0.005 ) ,在长链酰肉毒碱的 0.04 micromol/L (P <
0.05 ) ,在全部的肉毒碱的 8.7 micromol/L (P <
0.001 ) 。在恶病质病人与或没有胃肠的癌症,差别是在免费肉毒碱的 12.2 micromol/L ( P <
0.001 ),在短链酰肉毒碱的 4.60 micromol/L ( P <
0.001 ),并且在长链的酰肉毒碱的 0.60 微摩尔 /L ( P <
0.005 )并且在全部的肉毒碱的 17.4 micromol/L ( P <
0.001 )。在有胃肠的癌症和健康控制题目的恶病质病人,差别是在免费肉毒碱的 15.5 micromol/L ( P <
0.001 ),在短链的酰肉毒碱的 5.2 微摩尔 /L ( P <
0.001 ),在长链酰肉毒碱的 1.0 micromol/L ( P <
0.001 ),并且在全部的肉毒碱的 21.8 micromol/L ( P <
0.001 )。结论:在终端的肉毒碱的低浆液层次肿瘤的病人由于减少的饮食的吸入极大地被减少并且损害了这种物质的内长的合成。这些低浆液肉毒碱层次也在癌症病人贡献极度瘦弱的前进。 | Mariano Malaguarnera Corrado Risino Maria Pia Gargante Giovanni Oreste Gloria Barone Anna Veronica Tomasello Mario Costanzo Matteo Angelo Cannizzaro | 2006 | World Journal of Gastroenterology2006，12，28： | 3 |
| 4 | Default-mode network connectivity in cognitively unimpaired patients with Parkinson disease显示文摘 | Alessandro Tessitore Fabrizio Esposito Carmine Vitale Gabriella Santangelo Marianna Amboni Antonio Russo Daniele Corbo Giovanni Cirillo Paolo Barone Gioacchino Tedeschi | 2012 | Neurology2012，，23： | 1 |
| 5 | Continuous intestinal infusion of levodopaJcarbidopa in advanced Parkinson's disease:efficacy, safety and patient selection 显示文摘 | Giovanni Abbruzzese Paolo Barone Ubaldo Botxuccelli | 2012 | Funct Neurol2012，27，3： | 1 |
| 6 | 7-Year Survival Results of Perioperative Chemotherapy with Epidoxorubicin, Etoposide, and Cisplatin (EEP) in Locally Advanced Resectable Gastric Cancer: Up-to-date Analysis of a Phase-II Study显示文摘 | Roberto Persiani Stefano Rausei Carmelo Pozzo Alberto Biondi Carlo Barone Ferdinando C. M. Cananzi Giovanni Schinzari Domenico D’Ugo | 2008 | Annals of Surgical Oncology2008，，8： | 1 |
| 7 | The relevance of anatomic and hemodynamic factors to a classification of cerebral arteriovenous malformations 显示文摘 | Alberto Pasqualin Giovanni Barone Fabrizia Cioffi | 1991 | Neurosurgery1991，28，： | 1 |
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