|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Characteristics of human fetal spinal cord grafts in the adult rat spinal cord : influences of lesion and grafting conditions 显示文摘 | Giovanini MA Reier PJ Eskin TA | 1997 | Exp Neurol1997，2，： | 1 |
| 2 | Game approach to distributed model predictive control显示文摘 | Giovanini L | | 0，，15： | 1 |
| 3 | Addressing population heterogeneity and distribution in epidemics models using a cellular automata approach显示文摘 | López L Burguerner G Giovanini L | 2014 | BMC Res Notes2014，7，： | 1 |
| 4 | Characteristics of human fetal spinal cord grafts in the adult rat spinal cord: influences of lesion and grafting conditions显示文摘 | Giovanini MA Reier PJ Eskin TA | 1997 | Exp Neurol1997，148，2： | 1 |
| 5 | A primary and backup cooperative protection system based on wide area agents显示文摘 | Giovanini R Hopkinson K Coury D V | 2006 | IEEE Trans on Power Delivery2006，21，3： | 1 |
| 6 | A Primary and Backup Cooperative Protection System Based on Wide Area Agents显示文摘 | Giovanini R Hopkinson K Coury D V | 2006 | IEEE Transactions on power delivery2006，21，3： | 1 |
| 7 | Recovery of valuable elements from spent Li-batteries显示文摘 | Jéssica Frontino Paulino Natália Giovanini Busnardo Julio Carlos Afonso | 2007 | Journal of Hazardous Materials2007，，3： | 1 |
| 8 | EPOCHS:a platform for agent-based electric power and communication simulation built from commercial off-the- shelf components显示文摘 | Hopkinson K Wang X R Giovanini R | 2006 | IEEE Transactions on Power Systems2006，21，2： | 1 |
| 9 | A primary and backup cooperative protection system based on wide area agents显示文摘 | Giovanini R Hopkinson K Coury D V | 2006 | IEEE Transactions on Power Delivery2006，21，3： | 1 |
| 10 | EPOCHS:a platform for agent-based electric power and communication simulation built from commercial off-the-shelf components 显示文摘 | HOPKINSON K WANG Xiaoru GIOVANINI R | 2006 | IEEE Trans on Power Systems2006，21，2： | 1 |
| 11 | EPOCHS: a platform for agent-based electric power and communication simulation built from commercial off-the-shelf components 显示文摘 | HOPKINSON K WANG Xiaoru GIOVANINI R | 2006 | IEEE Trans on Power Systems2006，21，2： | 1 |
| 12 | EPOCHS: a platform for agent-based electric power andcommunication simulation built from commercialoff-the-shelf components 显示文摘 | Hopkinson K Wang Xiaoru Giovanini R | 2006 | IEEE Transactions on PowerSystems2006，21，2： | 1 |
| 13 | A primary andbackup cooperative protection system based on wide areaagents 显示文摘 | Giovanini R Hopkinson K Coury D | 2006 | IEEE Transactions on Power Delivery2006，21，3： | 1 |
| 14 | EPOCHS= a platform for agent-based electric power and communication simulation built from commercial off-the-shelf components显示文摘 | HOPKINSON K M WANG Xiaoru GIOVANINI R | 2006 | IEEE Trans on Power Systems2006，21，2： | 1 |
| 15 | Platelet-rich plasma (PRP) impairs the craniofacial bone repair associated with its elevated TGF-β levels and modulates the co-expression between collagen III and α-smooth muscle actin显示文摘 | Giovanini AF Gonzaga CC Zielak JC | | 0，，03： | 1 |
| 16 | A primary and backup cooperative protection system based on wide area agents显示文摘 | Giovanini R Hopkinson K Coury D V | 2006 | IEEE Trans on Power Delivery2006，21，3： | 1 |
| 17 | Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate显示文摘BACKGROUND The epiphyseal growth plate is an important anatomical segment localized on the ends of a long bone.Despite the abovementioned atractive reasons for alendronate’s use,few data on the effect of alendronate during epiphyseal growth exist.AIM Verify the effect of alendronate on the growth epiphyseal plate,and compare its effect with the size of the femur during the double-staining of the immunolocalization of transforming growth factor-β1(TGF-β1)and bone morphogenetic protein-2(BMP2)in endochondral ossifing in specimens that have received alendronate.METHODS Forty newborn rats were randomly divided into two groups:a control group(were given applications of 1 mg/kg physiologic saline)and a group that received Alendronate(a dose of 2.5 mg/kg).These groups were then divided into two subgroups for euthanasia in two and 12 d of life.After euthanasia,the femurs were removed,and the femoral bones were measured linearly between the apex of the greater trochanter until the lower intercondylar midlle face to verify the probable bone growth between 3 and 12 d in control and alednroanto treated rats.Posteriorly,the surgical pieces were also sent to the histopathology laboratory to produce histological slides.The obtained slides were stained with hematoxylin and eosin to measure each of the cartilage zones in endochondral development.and other slides were immunohistochemically tested for anti-TGF-β1 and BMP-2 antibodies to investigate the immunolocalization of these proteins in the epiphyseal plaque area.RESULTS On the third day,some diferences between the control group and specimens treated with alendronate were verified.Macroscopiccaly,we found similarities in size between the femoral bones when we compared the control group with the specimens that received alendronate.On the 12^th day,the bone size of the mice receiving the drug was significantly smaller than those of the control group.These results coincide with changes in the TGF-β1 and BMP-2 expression.In the specimens that received alendronate,the TGF-β1 was expressed in some sites of trabecular bone that was neoformed,peripherally to the bone marrow area.The BMP-2 was also positive in proliferative chondrocytes and hypertrofic chondrocytes.On the 12^th day,all layers of chondrocytes exhibited positivity for BMP-2 in the specimens that received alendronate.In the interface between the trabecular bone and cartilage,an area of disorganized bone deposition was evident.Neoformed bone also appeared to be different at 12 d.In the control group,BMP-2 was positive in an intense area of bone trabeculae,whereas the alendronate-treated group showed TGF-β1 positive trabeculae and a greater bone area.CONCLUSION Alendronate alters the immunolocalization of TGF-β1 and BMP-2 simultaneously,a condition that changes the usual histological aspects of the cartilage zone and impairs epiphysis growth and femur growth. | Juliana Souza Vieira Emanuelle Juliana Cunha Juliana Feltrin de Souza Luis Henrique Koeler Chaves Jessica Lakes de Souza Allan Fernando Giovanini | 2020 | World Journal of Experimental Medicine2020，10，1： | 1 |
| 18 | A primary and backup cooperative protection system based on wide area agents 显示文摘 | Giovanini R Hopkinson K Coury D V | 2006 | IEEE Transactions on Power Delivery2006，21，3： | 1 |
| 19 | Characteristics of human fetal spinal cord grafts in the adult rat spinal cord: influ-ences of lesion and grafting conditions 显示文摘 | Giovanini M A Reier P J Eskin T A | 1997 | Exp Neurol1997，148，2： | 1 |
| 20 | A primary and backup cooperative protection system based on wide area agents显示文摘 | Giovanini R Hopkinson K Coury D V | 2006 | IEEE Trans on Power Delivery2006，21，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员