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| 1 | Third-line rescue therapy for Helicobacter pylori infection显示文摘H pylori 胃的感染是世界范围的最流行的传染病之一。很上面的胃肠的疾病与 H pylori 感染有关能因此与抗菌素被对待的发现是重要医药进展。当前,首要的三倍的治疗被所有一致会议和指南基于质子泵禁止者(PPI ) 或加二抗菌素(clarithromycin 和 amoxicillin 或 nitroimidazole ) 的 ranitidine 枸橼酸铋(RBC ) 推荐。甚至与这药联合的正确使用,感染不能在多达 23% 病人被根除。因此,几第二线治疗被推荐了。7 d 四倍的治疗基于 PPI,铋,四圜素和灭滴灵,更多经常被接受。与第二线的治疗,然而,细菌的根除可以在多达 40% 盒子失败。当 H pylori 根除严格地被显示时,进一步的治疗的选择是争论的。当前,标准第三线的治疗正在缺乏,各种各样的协议被建议了。甚至在二连续失败以后,最近的文学数据证明了 H pylori 根除能在几乎所有病人被完成,甚至当抗菌素危险性没被测试时。实验治疗的不同可能性存在,可得到的第三线的策略此处被考察。 | Rossella Cianci Massimo Montalto Franco Pandolfi Giovan Battista Gasbarrini Giovanni Cammarota | 2006 | World Journal of Gastroenterology2006，12，15： | 31 |
| 2 | Laser ablation for small hepatocellular carcinoma: State of the art and future perspectives显示文摘During the last two decades, various local thermal ablative techniques for the treatment of unresectable hepatocellular carcinoma(HCC) have been developed. According to internationally endorsed guidelines, percutaneous thermal ablation is the mainstay of treatment in patients with small HCC who are not candidates for surgical resection or transplantation. Laser ablation(LA) represents one of currently available loco-ablative techniques. In this article, the general principles, technique, image guidance, and patient selection are reported. Primary effectiveness, long-term outcome, and complications are also discussed. A review of published data suggests that LA is equivalent to the more popular and widespread radiofrequency ablation in both local tumor control and long-term outcome in the percutaneous treatment of early HCC. In addition, the LA technique using multiple thin laser fibres allows improved ablative effectiveness in HCCs greater than 3 cm. Reference centres should be equipped with all the available techniques so as to be able to use the best and the most suitable procedure for each type of lesion for each patient. | Giovan Giuseppe Di Costanzo Giampiero Francica Claudio Maurizio Pacella | 2014 | World Journal of Hepatology2014，6，10： | 14 |
| 3 | Intermediate hepatocellular carcinoma: How to choose the best treatment modality?显示文摘Intermediate stage, or stage B according to Barcelona Clinic Liver Cancer classification, of hepatocellular carcinoma(HCC) comprises a heterogeneous population with different tumor burden and liver function. This heterogeneity is confirmed by the large variability of treatment choice and disease-relate survival. The aim of this review was to highlight the existing evidences regarding this specific topic. In a multidisciplinary evaluation, patients with large(> 5 cm) solitary HCC should be firstly considered for liver resection(LR). When LR is unfeasible, locoregional treatments are evaluable therapeutic options, being transarterial chemoembolization(TACE), the most used procedure. Percutaneous ablation can be an evaluable treatment for large HCC. However, the efficacy of all ablative procedures decrease as tumor size increases over 3 cm. In clinical practice, a combination treatment strategy [TACE or transarterial radioembolization(TARE)-plus percutaneous ablation] is 'a priori' preferred in a relevant percentage of these patients. On the other hands, sorafenib is the treatment of choice in patients who are unsuitable to surgery and/or with a contraindication to locoregional treatments. In multifocal HCC, TACE is the first-line treatment. The role of TARE is still undefined. Surgery may have also a role in the treatment of multifocal HCC in selected cases(patients with up to three nodules, multifocal HCC involving 2-3 adjacent liver segments). In some patients with bilobar disease the combination of LR and ablative treatment may be a valuable option. The choice of the best treatment in the patient with intermediate stage HCC should be 'patient-tailored' and made by a multidisciplinary team. | Giovan Giuseppe Di Costanzo Raffaella Tortora | 2015 | World Journal of Hepatology2015，7，9： | 12 |
| 4 | Analysis of surgical and perioperative complications in seventy-five right hepatectomies for living donor liver transplantation显示文摘AIM: To present an analysis of the surgical and perioperative complications in a series of seventy- five right hepatectomies for living-donation (RHLD) performed in our center. METHODS: From January 2002 to September 2007, we performed 75 RHLD, defined as removal of a portion of the liver corresponding to Couinaud segments 5-8, in order to obtain a graft for adult to adult living-related liver transplantation (ALRLT). Surgical complications were stratified according to the most recent version of the Clavien classification of postoperative surgical complications. The perioperative period was defined as within 90 d of surgery. RESULTS: No living donor mortality was present in this series, no donor operation was aborted and no donors received any blood transfusion. Twenty- three (30.6%) living donors presented one or more episodes of complication in the perioperative period. Seven patients (9.33%) out of 75 developed biliary complications, which were the most common complications in our series.CONCLUSION: The need to define, categorize and record complications when healthy individuals, such as living donors, undergo a major surgical procedure, such as a right hepatectomy, reflects the need for prompt and detailed reports of complications arising in this particular category of patient. Perioperative complications and post resection liver regeneration are not influenced by anatomic variations or patient demographic. | Salvatore Gruttadauria James Wallis Marsh Giovan Battista Vizzini Fabrizio di Francesco Angelo Luca Riccardo Volpes Amadeo Marcos Bruno Gridelli | 2008 | World Journal of Gastroenterology2008，14，20： | 7 |
| 5 | Post-transplantation hepatocellular carcinoma recurrence: Patterns and relation between vascularity and differentiation degree显示文摘AIM: To evaluate the relationship between hepatocellular carcinoma(HCC) vascularity and grade; to describe patterns and vascular/histopathological variations of post-transplantation recurrence.METHODS: This retrospective study included 165 patients(143 men, 22 women; median age 56.8 years, range 28-70.4 years) transplanted for HCC who had a follow-up period longer than 2 mo. Pre-transplantation dynamic computed tomography or magnetic resonance examinations were retrospectively reviewed, classifying HCC imaging enhancement pattern into hypervascular and hypovascular based on presence of wash-in during arterial phase. All pathologic reports of the explanted livers were reviewed, collecting data about HCC differentiation degree. The association between imaging vascular pattern and pathological grade was estimated using the Fisher exact test. All follow-up clinical and imaging data were reviewed for evidence of recurrence. Recurrence rate was calculated and imaging features of recurrent tumor were collected, classifying early and late recurrences based on timing(< or ≥ 2 years after transplantation) and intrahepatic, extrahepatic and both intrahepatic and extrahepatic recurrences based onlocation. All intrahepatic recurrences were classified as hypervascular or hypovascular and the differentiation degree was collected where available. The presence of variations in imaging enhancement pattern and pathological grade between the primary tumor and the intrahepatic recurrence was evaluated and the association between imaging and histopatholgical variations was estimated by using the χ2 test. RESULTS: Of the 163 patients with imaging evidence of viable tumor, 156(95.7%) had hypervascular and 7(4.3%) hypovascular HCC. Among the 125 patients with evidence of viable tumor in the explanted liver, 19(15.2%) had grade 1, 56(44.8%) grade 2, 40(32%) grade 3 and 4(3.2%) grade 4 HCC, while the differentiation degree was not assessable for 6 patients(4.8%). A significant association was found between imaging vascularity and pathological grade(P = 0.035). Post-transplantation recurrence rate was 14.55%(24/165). All recurrences occurred in patients who had a hypervascular primary tumor. Three patients(12.5%) experienced late recurrence; the location of the first recurrence was extrahepatic in 14 patients(58.3%), intrahepatic in 7 patients(29.2%) and both intrahepatic and extrahepatic in 3 patients(12.5%). Two patients had a variation in imaging characteristics between the primary HCC(hypervascular) and the intrahepatic recurrent HCC(hypovascular), while 1 patient had a variation of histopathological characteristics(from moderate to poor differentiation), however no association was found between imaging and histopathological variations.CONCLUSION: A correlation was found between HCC grade and vascularity; some degree of variability may exist between the primary and the recurrence imaging/histopathological characteristics, apparently not correlated. | Annarita Pecchi Giulia Besutti Mario De Santis Cinzia Del Giovane Sofia Nosseir Giuseppe Tarantino Fabrizio Di Benedetto Pietro Torricelli | 2015 | World Journal of Hepatology2015，7，2： | 5 |
| 6 | Safety and effectiveness of sorafenib in patients with hepatocellular carcinoma in clinical practice显示文摘 | Giovan Giuseppe Di Costanzo Raffaella Tortora Luca Iodice Alfonso Galeota Lanza Filippo Lampasi Maria Teresa Tartaglione Francesco Paolo Picciotto Silvana Mattera Massimo De Luca | 2012 | Digestive and Liver Disease2012，，9： | 2 |
| 7 | Hepatitis B virus reactivation after a single session of transarterial chemoembolization in patients with Hepatocellular carcinoma显示文摘 | Giovan BV Angelo L Ignazio RM | 2003 | Annals of Internal Medicine2003，138，8： | 1 |
| 8 | Non-steroid agents for idiopathic pulmonary fibrosis显示文摘 | Spagnolo P Del Giovane C Luppi F | 2010 | Cochrane Database Syst Rev2010，8，9： | 1 |
| 9 | Comp lementary therapy forpsoriasis显示文摘 | Giovan Lu gi Capella A|ido F!Finzil | 2003 | Dermatologic Therapy2003，16，： | 1 |
| 10 | Perceived and measured inflation after the launch of the euro:Explaining the gap in Italy显示文摘 | Del Giovane P Sabbatini R | | 0，，02： | 1 |
| 11 | The introduction of the euro and the divergence between officially measured and perceived inflation:The case of Italy显示文摘 | Del Giovane R Sabbatini | | 0，，： | 1 |
| 12 | Semi -batch emulsion copolymerization of styrene and butyl acrylate for production of high solids content latexes:Experiments and mathematical model 显示文摘 | Giovane M Wilson H Reinaldo G | 2011 | Chemical Engineering Science2011，66，23： | 1 |
| 13 | Perceived and measured inflation after the launch of the euro:explaining the gap in Italy显示文摘 | Del Giovane R Sabbatini | | 0，，： | 1 |
| 14 | β-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo:involvement of the p38MAPK pathway显示文摘 | Maria G Giovan N Carla S | 2002 | J Neuro Bio2002，8，11： | 1 |
| 15 | Diagnostic laparoscopy in nontraumatic abdominal emergencies显示文摘 | Faggi U Giovane A | 2003 | Minerva Chir2003，58，1： | 1 |
| 16 | High glucose downregulates endothelial progenitor cell number via SIRT1 显示文摘 | Mafia Luisa Balestrieri Monica Rienzo Francesca Felice Raffaele Rossiello Vincenzo Grimaldi Lara Milone Amelia Casamassimi Luigi Servillo Bartolomeo Farzati Alfonso Giovane Claudio Napoli | 2008 | Biochimica et BiophysicaAc ta2008，17，84： | 1 |
| 17 | Non-steroid agents for idiopathic pulmonary fibrosis 显示文摘 | Spagnolo P Del Giovane C Luppi F | 2010 | Cochrane Database Syst Rev2010，，00： | 1 |
| 18 | Non-steroid agentsfor idiopathic pulmonary fibrosis显示文摘 | Spagnolo P Del Giovane C Luppi F | 2010 | Cochrane Database Syst Rev2010，9，00： | 1 |
| 19 | β-amyloid-induced inflammation and cholinergic hypofunction in the rat brain in vivo:involvement of the p38MAPK pathway显示文摘 | Maria G Giovan N Carla S | 2002 | J Neuro Bio2002，8，11： | 1 |
| 20 | Low complexity Turbo equalization for power line communications显示文摘 | Adebisi B Giovaneli C L Honary B | 2006 | IEEE Trans Commun2006，50，4： | 1 |
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