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| 1 | DNA and histone methylation in gastric carcinogenesis显示文摘Epigenetic alterations contribute significantly to the development and progression of gastric cancer,one of the leading causes of cancer death worldwide.Epigenetics refers to the number of modifications of the chromatin structure that affect gene expression without altering the primary sequence of DNA,and these changes lead to transcriptional activation or silencing of the gene.Over the years,the study of epigenetic processes has increased,and novel therapeutic approaches that target DNA methylation and histone modifications have emerged.A greater understanding of epigenetics and the therapeutic potential of manipulating these processes is necessary for gastric cancer treatment.Here,we review recent research on the effects of aberrant DNA and histone methylation on the onset and progression of gastric tumors and the development of compounds that target enzymes that regulate the epigenome. | Danielle Queiroz Calcagno Carolina Oliveira Gigek Elizabeth Suchi Chen Rommel Rodriguez Burbano Marília de Arruda Cardoso Smith | 2013 | World Journal of Gastroenterology2013，19，8： | 14 |
| 2 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 3 | STEP based geometric and topological similarity assessment of mechanical parts 显示文摘 | GIGEK A | 2007 | Mathematical and Computational Applications2007，12，3： | 1 |
| 4 | Promoter methylation analysis of SIRT3,SMARCA5,HTERT and CDH1 genes in aging and Alzheimer's disease显示文摘 | Silva P N Gigek C O Leal M F | 2008 | J Alzheimers Dis2008，13，2： | 1 |
| 5 | Promoter methy- lation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer' s disease显示文摘 | SILVA P N GIGEK C O LEAL M F et 01 | 2008 | Journal of Alzheim- er''s Disease2008，13，2： | 1 |
| 6 | Association of lipase lipoprotein polymorphisms with high-density lipoprotein and triglycerides in eldedy men显示文摘 | Araújo LM Cendoroglo MS Gigek CO | | 0，，01： | 1 |
| 7 | hTERT methylation and expression in gastric cancer显示文摘 | Carolina Oliveira Gigek Mariana Ferreira Leal Patricia Natalia Oliveira Silva Luara Carolina Frias Lisboa Eleonidas Moura Lima Danielle Queiroz Calcagno Paulo Pimentel Assump??o Rommel Rodriguez Burbano Marilia de Arruda Cardoso Smith | 2009 | Biomarkers2009，，8： | 1 |
| 8 | Association of lipase lipoprotein polymorphisms with high-density lipoprotein and tri- glycerides in elderly men显示文摘 | Araajo LM Cendoroglo MS Gigek CO | 2010 | Genet Mol Res2010，9，1： | 1 |
| 9 | hTERT methylation and expres- sion in gastric cancer显示文摘 | Gigek CO Leal MF Silva PN | 2000 | Biomarkers2000，14，8： | 1 |
| 10 | Epigenetic mechanisms in gastric cancer显示文摘 | Gigek CO Chen ES Calcagno DO | 2012 | Epigenomics2012，4，3： | 1 |
| 11 | Promoter methylation anal- ysis of SIRT3,SMARCAS, HTERT and CDH1 genes in aging and Alzheimer's disease显示文摘 | Silva PN Gigek CO Leal MF | 2008 | Alzheimers Dis2008，13，2： | 1 |
| 12 | Association of lipsse lipoprotein polymorphisms with myocardial infarction and lipid levels显示文摘 | Gigek CO Chen ES Cendoroglo MS | 2007 | Clin Chem Lab Med2007，45，： | 1 |
| 13 | Epigenetic mechanisms in gastric cancer显示文摘 | Gigek CO Chen ES Calcagno DQ | | 0，，3： | 1 |
| 14 | Association of COX2 gene hypomethylation with intestinal type gastric cancer in samples of patients from northern Brazil显示文摘 | Cynthia Farias Vieira Melo Carolina Oliveira Gigek Juarez Nóbrega Silva Marilia de Arruda Cardoso Smith Rubistenia Miranda Araújo Rommel Rodríguez Burbano Eleonidas Moura Lima | 2014 | Tumor Biology2014，，2： | 1 |
| 15 | hTERT methylation and expression in gastric cancer 显示文摘 | Gigek CO Leal M F Silva PNO | 2009 | Biomarkers2009，14，8： | 1 |
| 16 | Association of lipase lipoprotein polymorphisms with high-density lipoprotein and triglyeerides in elderly men显示文摘 | / ARAUJO L CENDOROGLO M GIGEK C | 2010 | GenetMol Res2010，9，： | 1 |
| 17 | Reference genes for quantitative RT-PCR data in gastric tissues and cell lines显示文摘AIM:To evaluate the suitability of reference genes in gastric tissue samples and cell lines.METHODS:The suitability of genes ACTB,B2M,GAPDH,RPL29,and 18S rRNA was assessed in21 matched pairs of neoplastic and adjacent nonneoplastic gastric tissues from patients with gastric adenocarcinoma,27 normal gastric tissues from patients without cancer,and 4 cell lines using reverse transcription quantitative real-time polymerase chain reaction(RT-qPCR).The ranking of the best single and combination of reference genes was determined by NormFinder,geNorm,BestKeeper,and DataAssist.In addition,GenEx software was used to determine the optimal number of reference genes.To validate the results,the mRNA expression of a target gene,DNMT1,was quantified using the different reference gene combinations suggested by the various software packages for normalization.RESULTS:ACTB was the best reference gene for all gastric tissues,cell lines and all gastric tissues plus cell lines.GAPDH+B2M or ACTB+B2M was the best combination of reference genes for all the gastric tissues.On the other hand,ACTB+B2M was the best combination for all the cell lines tested and was also the best combination for analyses involving all the gastric tissues plus cell lines.According to the GenEx software,2 or 3 genes were the optimal number of references genes for all the gastric tissues.The relative quantification of DNMT1 showed similar patterns when normalized by each combination of reference genes.The level of expression of DNMT1 in neoplastic,adjacent non-neoplastic and normal gastric tissues did not differ when these samples were normalized using GAPDH+B2M(P=0.32),ACTB+B2M(P=0.61),or GAPDH+B2M+ACTB(P=0.44).CONCLUSION:GAPDH+B2M or ACTB+B2M is the best combination of reference gene for all the gastric tissues,and ACTB+B2M is the best combination for the cell lines tested. | Fernanda Wisnieski Danielle Queiroz Calcagno Mariana Ferreira Leal Leonardo Caires dos Santos Carolina de Oliveira Gigek Elizabeth Suchi Chen Thaís Brilhante Pontes Paulo Pimentel Assumpo Mnica Barauna de Assumpo Smia Demachki Rommel Rodríguez Burbano Marília de Arruda Cardoso Smith | 2013 | World Journal of Gastroenterology2013，19，41： | 0 |
| 18 | Metastasis-associated lung adenocarcinoma transcript 1 molecular mechanisms in gastric cancer progression显示文摘Gastric cancer(GC)remains among the most common cancers worldwide with a high mortality-to-incidence ratio.Accumulated evidence suggests that long noncoding RNAs(lncRNAs)are involved in gastric carcinogenesis.These transcripts are longer than 200 nucleotides and modulate gene expression at multiple molecular levels,inducing or inhibiting biological processes and diseases.Metastasis-associated lung adenocarcinoma transcript 1(MALAT1)is one of the best-studied lncRNAs with comprehensive actions contributing to cancer progression.This lncRNA regulates gene expression at the transcriptional and posttranscriptional levels through interactions with microRNAs and proteins.In the present review,we discussed the molecular mechanism of MALAT1 and summarized the current knowledge of its expression in GC.Moreover,we highlighted the potential use of MALAT1 as a biomarker,including liquid biopsy. | Daniel Mateus de Oliveira Batista Jessica Manoelli Costa da Silva Carolina de Oliveira Gigek Marilia de Arruda Cardoso Smith Paulo Pimentel de Assumpcao Danielle Queiroz Calcagno | 2023 | World Journal of Gastrointestinal Oncology2023，15，9： | 0 |
| 19 | Identification of IL11RA and MELK amplification in gastric cancer by comprehensive genomic profiling of gastric cancer cell lines显示文摘AIM To identify common copy number alterations on gastric cancer cell lines.METHODS Four gastric cancer cell lines(ACP02, ACP03, AGP01 and PG100) underwent chromosomal comparative genome hybridization and array comparative genome hybridization. We also confirmed the results by fluorescence in situ hybridization analysis using the bacterial artificial chromosome clone and quantitative real time PCR analysis.RESULTS The amplification of 9p13.3 was detected in all cell lines by both methodologies. An increase in the copy number of 9p13.3 was also confirmed by fluorescence in situ hybridization analysis. Moreover, the interleukin 11 receptor alpha(IL11RA) and maternal embryonic leucine zipper kinase(MELK) genes, which are present in the 9p13.3 amplicon, revealed gains of the MELK gene in all the cell lines studied. Additionally, a gain in the copy number of IL11 RA and MELK was observed in 19.1%(13/68) and 55.9%(38/68) of primary gastric adenocarcinoma samples, respectively. CONCLUSION The characterization of a small gain region at 9p13.3 in gastric cancer cell lines and primary gastric adenocarcinoma samples has revealed MELK as a candidate target gene that is possibly related to the development of gastric cancer. | Danielle Queiroz Calcagno Sylvia Santomi Takeno Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Elizabeth Suchi Chen Taíssa Maíra Thomaz Araújo Eleonidas Moura Lima Maria Isabel Melaragno Samia Demachki Paulo Pimentel Assumpcao Rommel Rodriguez Burbano Marília Cardoso Smith | 2016 | World Journal of Gastroenterology2016，22，43： | 0 |
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