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| 1 | Efficacy and safety of tenofovir in chronic hepatitis B: Australian real world experience显示文摘AIM To evaluate the long-term treatment outcomes of tenofovir therapy in patients in a real world Australian tertiary care setting.METHODS We performed a retrospective analysis of treatment outcomes among treatment-na?ve and treatment-experienced patients receiving a minimum 3 mo tenofovir therapy through St Vincent's Hospital Melbourne, Australia. We included patients receiving tenofovir [tenofovir disoproxil fumarate(TDF)] monotherapy, as well as patients treated with TDF in combination with a second antiviral agent. Patients were excluded if they demonstrated human immune-deficiency virus/hepatitis C virus/hepatitis delta virus coinfection or were less than 18 years of age. We considered virological and biochemicalresponse, as well as safety outcomes. Virological response was determined by measurement of hepatitis B virus(HBV) DNA using sensitive assays; biochemical response was determined via serum liver function tests; histological response was determined from liver biopsy and fibroscan; safety analysis focused on glomerular renal function and bone mineral density. The primary efficacy endpoint was complete virological suppression over time, defined by HBV DNA < 20 IU/m L. Secondary efficacy endpoints included rates of biochemical response, and HB e antigen(HBe Ag)/HB surface antigen loss and seroconversion over time.RESULTS Ninety-two patients were identified who fulfilled the enrolment criteria. Median follow-up was 26 mo(range 3-114). Mean age was 46(24-78) years, 64(70%) were male and 77(84%) were of Asian origin. 55(60%) patients were treatment-na?ve and 62 patients(67%) were HBe Ag-negative. Complete virological suppression was achieved by 45/65(71%) patients at 12 mo, 37/46(80%) at 24 mo and 25/28(89%) at 36 mo. Partial virological response(HBV DNA 20-2000 IU/m L) was achieved by 89/92(96.7%) of patients. Multivariate analysis showed a significant relationship between virological suppression at end of follow-up and baseline HBV DNA level(OR = 0.897, 95%CI: 0.833-0.967, P = 0.0046) and HBe Ag positive status(OR = 0.373, 95%CI: 0.183-0.762, P = 0.0069). There was no difference in response comparing treatment-na?ve and treatment-experienced patients. Three episodes of virological breakthrough occurred in the setting of noncompliance. Tenofovir therapy was well tolerated.CONCLUSION Tenofovir is an efficacious, safe and well-tolerated treatment in an Australian real-world tertiary care setting. Our data are similar to the reported experience from registration trials. | Grace C Lovett Tin Nguyen David M Iser Jacinta A Holmes Robert Chen Barbara Demediuk Gideon Shaw Sally J Bell Paul V Desmond Alexander J Thompson | 2017 | World Journal of Hepatology2017，9，1： | 7 |
| 2 | Portal hypertension in polycystic liver disease patients does not affect wait-list or immediate post-liver transplantation outcomes显示文摘AIM To establish the impact of portal hypertension(PH) on wait-list/post-transplant outcomes in patients with polycystic liver disease(PCLD) listed for liver transplantation. METHODS A retrospective single-centre case controlled study of consecutive patients listed for liver transplantation over 12 years was performed from our centre. PH in the PCLD cohort was defined by the one or more of following parameters:(1) presence of radiological or endoscopic documented varices from our own centre or the referral centre;(2) splenomegaly(> 11 cm) on radiology inabsence of splenic cysts accounting for increased imaging size;(3) thrombocytopenia(platelets < 150 × 109/L); or(4) ascites without radiological evidence of hepatic venous outflow obstruction from a single cyst. RESULTS Forty-seven PCLD patients(F: M = 42: 5) were listed for liver transplantation(LT)(single organ, n = 35; combined liver-kidney transplantation, n = 12) with 19 patients(40.4%) having PH. When comparing the PH group with non-PH group, the mean listing age(PH group, 50.6(6.4); non-PH group, 47.1(7.4) years; P = 0.101), median listing MELD(PH group, 12; non-PH group, 11; P = 0.422) median listing UKELD score(PH group, 48; non-PH group, 46; P = 0.344) and need for renal replacement therapy(P = 0.317) were similar. In the patients who underwent LT alone, there was no difference in the duration of ICU stay(PH, 3 d; non-PH, 2 d; P = 0.188), hospital stay length(PH, 9 d; non-PH, 10 d; P = 0.973), or frequency of renal replacement therapy(PH, 2/8; non-PH, 1/14; P = 0.121) in the immediate post-transplantation period. CONCLUSION Clinically apparent portal hypertension in patients with PCLD listed for liver transplantation does not appear to have a major impact on wait-list or peri-transplant morbidity. | Neil Rajoriya Dhiraj Tripathi Joanna A Leithead Bridget K Gunson Sophie Lord James W Ferguson Gideon M Hirschfield | 2016 | World Journal of Gastroenterology2016，22，45： | 2 |
| 3 | Study of diffusion and weighted magnetic resonance imaging in human stroke显示文摘 | Gideon A Sindgan B Gihisu P | 1994 | Stroke1994，25，3： | 1 |
| 4 | Person-entrepreneurship fit:Why some people are more successful as entrepreneurs than others显示文摘 | Markman Gideon D and Baron Robert A | 2003 | Human Resource Management Review2003，13，2： | 1 |
| 5 | Total hip replacement due to osteoarthritis: the importance of age, obesity, and other modifiable risk factors显示文摘 | Elizabeth W Karlson Lisa A Mandl Gideon N Aweh Oliver Sangha Matthew H Liang Francine Grodstein | 2003 | The American Journal of Medicine2003，，2： | 1 |
| 6 | Personentrepreneurship Fit:Why Some People are More Successful as Entrepreneurs than Others显示文摘 | Gideon D Markman Robert A Baron | 2003 | Human Resource Management Review2003，，13： | 1 |
| 7 | Preoperative lower esophageal sphincter pressure affects outcome of laparoscopic esophageal myotomy for achalasia显示文摘 | Mustafa A Arain Jeffrey H Peters Anan P Tamhankar Giuseppe Portale Gideon Almogy Steven R DeMeester Peter F Crookes Jeffrey A Hagen Cedric G Bremner Tom R DeMeester | 2004 | Journal of Gastrointestinal Surgery2004，，3： | 1 |
| 8 | Vitamin D status and para- thyroid hormone in obese children before and after weight loss显示文摘 | Thomas R Gideon DS Ute A | 2007 | Eur J Endoerinol2007，157，6： | 1 |
| 9 | Influence of temperature and pH on biomass production and pro-tein biosynthesis in a putative Spirulina sp显示文摘 | Kemka H O Rebecca E A Gideon O A | 2007 | Biore-source Technology2007，，98： | 1 |
| 10 | Structural stability of concrete wind turbines and solar chimney towers exposed to dynamic wind action显示文摘 | Reinhard Harte Gideon P A G Van Zijl | 2007 | Journal of Wind Engineering and Industrial Aerodynamics2007，95，： | 1 |
| 11 | Intraoperative myocardial protection: current trends and future perspectives显示文摘 | Gideon Cohen Michael A Borger Richard D Weisel Vivek Rao | 1999 | The Annals of Thoracic Surgery1999，，5： | 1 |
| 12 | Critical levels for soil pH, available P, K, Zn and Mn and maize ear-leaf content of P, Cu and Mn in sedimentary soils of South-Western Nigeria显示文摘 | Gideon O Adeoye Akinola A Agboola | 1985 | Fertilizer Research1985，，1： | 1 |
| 13 | A study of natural attenuation processes involved in a microcosm model of a crude oil impacted wetland sediment in the Niger delta 显示文摘 | Gideon A Paschal D | 2008 | Bioresource Technology2008，99，11： | 1 |
| 14 | Contrasting bio- logical activities of thymopoietin and splenin, two closely related polypeptide products of thymus and spleen (thy- mopentin / splenopentin / immunoregulation) 显示文摘 | TAPAN A MARGRIT P S GIDEON G | 1984 | Pro- ceedings of the National Academy of Sciences1984，81，： | 1 |
| 15 | Person -entrepreneurship Fit:Why People are More Successful as Entrepreneurs than Others显示文摘 | Gideon D Markman Robert A Baron | 2003 | Human Resource Management Review2003，，13： | 1 |
| 16 | Dissociable Neural Pathways are involved in the recognition of e- motion in static and dynamic facial expressions 显示文摘 | Kilts C D Egan G Gideon D A | 2003 | NeuroImage2003，18，： | 1 |
| 17 | Bisphosphonates: Mechanisms of action显示文摘 | Gideon A Rodan LD Herbert A | 1996 | Clin Invest1996，97，22： | 1 |
| 18 | A study of the microbial quality of grey water and an evaluation of treatment technologies for reuse显示文摘 | Gideon P W Lisa M A Ronnie F W | 2008 | Ecological Engineering2008，32，2： | 1 |
| 19 | Beyond social capital: how social skills can enhance entrepreneurs' success 显示文摘 | BARON ROBERT A MARKMAN GIDEON D | 2000 | Academy of Management Executive2000，14，1： | 1 |
| 20 | Person-entre-preneurship fit:why some people are more successful asentrepreneurs than others显示文摘 | GIDEON D MARKMAN R BARON A | 2003 | Human Resource Manage-ment Review2003，13，2： | 1 |
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