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184篇 您的检索式:作者名="Gicquel"
    题名 作者 年代 出处 被引量
1应用ELISPOT试验测定重组卡介苗诱导的T细胞应答显示文摘应用免疫磁性分离技术去除免疫小鼠脾脏细胞中CD4+或CD8+T细胞后 ,在酶联免疫斑点试验中证实表达大肠杆菌MalE蛋白的重组卡介苗 (rBCG·MalE)诱导的T细胞应答是CD4+T细胞依赖的。对MalE、PPD特异T细胞应答的动态分析结果表明 ,rBCG·MalE、BCG诱导的特异CD4+T细胞应答存在Th1/Th2平衡转换现象 ,即起始阶段为Th1应答 ,一段时间后出现Th2应答 ,并逐步形成Th1/Th2混合应答。这些结果 ,为分枝杆菌T细胞应答规律提供了新的认识 ,同时 ,亦表明BCG是优良的外源抗原表达与运送载体。焦新安 RichardLo-man EdithD’eriaud Brigitte Gicquel Nathalie Winter Claude Leclerc 刘秀梵 2001中国预防兽医学报2001,23,1:7
2重组卡介苗表达的MalE蛋白T细胞表位的鉴定显示文摘目的 鉴定重组卡介苗表达的MalE蛋白T细胞表位。方法 用抗原提呈试验、T细胞增殖试验、ELISPOT试验和表位作图测试重组MalE蛋白的T细胞表位。结果 重组BCG MalE功能性表达了MalE蛋白的 4种H 2 d 限制性T细胞表位。结论 在 4种表位中 ,p6 8~ 82是重组MalE蛋白的主要T细胞表位 ,而其余焦新安 Richard Lo-man Edith Driaud Sophie Burgaud Brigitte Gicquel Nathalie Winter Claude Leclerc 刘秀梵 2002中华微生物学和免疫学杂志2002,22,1:3
3重组卡介苗感染树突细胞的研究显示文摘在体内外试验中 ,树突细胞 (DC)均能摄取表达大肠杆菌麦芽糖结合蛋白 (MalE)的重组卡介苗 (rBCG·MalE)。应用流式细胞术测得荧光标记的rBCG·MalE在体内感染DC的水平在 1 % 2 % ,与感染巨噬细胞 (MΦ)的水平相当。体外抗原提呈试验结果显示 ,DC和MΦ能吞噬、加工rBCG·MalE并向T细胞杂交瘤FBU·B1 1提呈MalE蛋白抗原表位 ,而在体内试验中 ,从rBCG·MalE免疫小鼠脾脏中纯化的DC ,可检测到MalE表位MHCⅡ复合物 ,而纯化的MΦs却测不到。这表明DC在起始抗分枝杆菌的免疫保护中发挥关键作用。焦新安 Richard Lo-Man Pierre Guermonprez Edith Dériaud Brigitte Gicquel Nathalie Winter Claude Leclerc 刘秀梵 2002扬州大学学报(农业与生命科学版)2002,23,1:2
4Assessment of Turner's syndrome by molecular analysis of the X chromone in growth retarded girls显示文摘 Gaston V Cabrol S 1998J Clin Endocrinal Metab1998,83,5:1
5Simultaneous determination of enrofloxacin and ciprofloxacin in animal biological fluids by high-performance liquid chromatography Application in pharmacokinetic studies in pig and rabbit显示文摘MANCEAU J GICQUEL M LAURENTIE M 1999Journal of Chromatography B1999,726,12:1
6An animal model for the study of chronopharmacokinetics of drugs and application to methotrexate and vinorelbine显示文摘PREMAUD A ROUSSEAU A GICQUEL M 2002Toxicol Appl Pharmacol2002,183,3:1
7Neuropeptide Y and neuron-specific enolas levels in benign and malignant pheochromocytomas显示文摘Grouzmann E Gicquel C Plouin PF 1990Cancer1990,66,8:1
8Premixed Turbulent Combustion Modelling Using Tabulated Detailed Chem- istry and PDF 显示文摘Fiorina B Gicquel O Vervisch L 2005Proc Combust Inst2005,30,:1
9Coupled effect of nitrogen addition and surface temperature on the morphology and the kinetics of thick CVD diamond single crystals显示文摘J. Achard F. Silva O. Brinza A. Tallaire A. Gicquel 2006Diamond & Related Materials2006,,4:1
10Laminar premixed hydrogen/air counterflow flame simulations using flame prolongation of ILDM with differential diffusion显示文摘Gicquel O Darabiha N Thevenin D 2000Proceedings of the Combustion Institute2000,28,2:1
11Tibial plateau fractures:reproducibility of three classifications(Schatzker,AO,Duparc) and a revised Duparc classification 显示文摘Gicquel T Najihi N Vendeuvre T 2013Orthop Traumatol Surg Res2013,99,7:1
12Large eddy simulations of gaseous flames in gas turbine combustion chambers显示文摘Gicquel L Y M Staffelbach G Poinsot T 2012Progress in Energy and Combustion Sci- ence2012,38,6:1
13Problems of operative and non-operative treatment and healing in tibial fractures显示文摘Gicquel P Giacomelli MC Basic B 2005Injury2005,,:1
14CVD diamond films: from growth to applications显示文摘Alix Gicquel Khaled Hassouni Francois Silva 2001Current Applied Physics2001,1,6:1
15Approximat- ing the chemical structure of partially premixed and diffusion counterflow flames using FPI flamelettabulation显示文摘Fiorina B Gicquel O Vervisch V 2005Combustion and Flame2005,140,3:1
16Increased levels of insulin-like growth factor Ⅱ (IGF-Ⅱ)and IGF-binding protein-2 are associated with malignaney in sporadic adrenoeortical tumors 显示文摘Boulle N Logie A Gicquel C 1998J Clin Endocrinol Metab1998,83,:1
17Biotrol System 7000 : automated immunoassay analyzer 显示文摘Freier CB Gicquel KT 1991J Clin lmmunoassay1991,14,2:1
18Express- ion of the angiogenesis markers vascular endothelial growth factor-A, thrombospondin-1, and platelet-derived endothelial cell growth factor in human sporadic adrenocortical tumors: correlation with genotypic alterations 显示文摘DE FRAIPONT F EL ATIFI M GICQUEL C 2000J Clin Endocrinol Metab2000,85,12:1
19Escherichia coli-Mycobacteria Shuttle Vectors for Operon and Gene Fusions to lacZ: the pJEM Series显示文摘TIMM J LIM E M GICQUEL B 1994Journal of Bacteriology1994,176,21:1
20Direct numerical simulation of turbulent premixed flames using intrinsic low-dimensional manifolds 显示文摘Gicquel O 1999Combustion Theory and Modelling1999,3,3:1
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