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| 1 | Dabigatran,rivaroxaban,and apixaban are superior to warfarin in Asian patients with non-valvular atrial fibrillation:An updated metaanalysis显示文摘BACKGROUND Most of the randomized clinical trials that led to the wide use of non-vitamin K antagonist oral anticoagulants for stroke prevention in patients with atrial fibrillation(AF)originated from western countries.AIM To systematically review and quantitatively synthesize the real-world data regarding the efficacy and safety of dabigatran,rivaroxaban,and apixaban compared to warfarin for stroke prevention in Asian patients with non-valvular AF.METHODS Medline,Cochrane,and ClinicalTrial.gov databases were reviewed.A randomeffect model meta-analysis was used and I-square was utilized to assess the heterogeneity.The primary outcome was ischemic stroke.The secondary outcomes were all-cause mortality,major bleeding,intracranial hemorrhage,and gastrointestinal bleeding.RESULTS Twelve studies from East Asia or Southeast Asia and 441450 patients were included.Dabigatran,rivaroxaban,and apixaban were associated with a significant reduction in the incidence of ischemic stroke[hazard ratio(HR)=0.78,95%confidence interval(CI):0.65-0.94;HR=0.79,95%CI:0.74-0.85,HR=0.70,95%CI:0.62-0.78;respectively],all-cause mortality(HR=0.68,95%CI:0.56-0.83;HR=0.66,95%CI:0.52-0.84;HR=0.66,95%CI:0.49-0.90;respectively),and major bleeding(HR=0.61,95%CI:0.54-0.69;HR=0.70,95%CI:0.54-0.90;HR=0.58,95%CI:0.43-0.78;respectively)compared to warfarin.CONCLUSION Dabigatran,rivaroxaban,and apixaban appear to be superior to warfarin in both efficacy and safety in Asians with non-valvular AF. | Wei-Jia Li Paraschos Archontakis-Barakakis Leonidas Palaiodimos Dimitrios Kalaitzoglou Lazaros Tzelves Apostolos Manolopoulos Yu-Chiang Wang Stefanos Giannopoulos Robert Faillace Damianos G Kokkinidis | 2021 | World Journal of Cardiology2021，13，4： | 3 |
| 2 | Biological sources and sinks of nitrous oxide and strategies to mitigate emissions显示文摘 | Thomson A J Giannopoulos G Pretty J | 2012 | Philosophical Transactions of the Royal Society B: Biological Sci- ences2012，367，1593： | 1 |
| 3 | Renoprotective effect of remote ischemic post-conditioning by intermittent balloon inflations in patients undergoing percutaneous coronary intervention 显示文摘 | DEFTEREOS S GIANNOPOULOS G TZALAMOURAS V | 2013 | J Am Coil Cardiol2013，61，19： | 1 |
| 4 | Cystatin C:an emerging biomarker in cardiovascular disease显示文摘 | Angelidis C Deftereos S Giannopoulos G | | 0，，02： | 1 |
| 5 | Colchicine and the heart: pushing the envelope显示文摘 | Deftereos S Giannopoulos G Papoutsidakis N | 2013 | J Am Coil Cardiol2013，62，20： | 1 |
| 6 | Moderate Procedur- al Sedation and Opioid Analgesia During Transradial Coronary Inter- ventions to Prevent Spasm: a prospective randomized study 显示文摘 | Deftereos S Giannopoulos G Raisakis K | 2013 | JACC Cardiovasc Interv2013，6，3： | 1 |
| 7 | Cardio protective role of remote ischemic periconditioning in primary percutaneous coronary intervention: enhancement by opioid action显示文摘 | Rentoukas I Giannopoulos G Kaoukis A | 2010 | JACC Cardiovasc Interv2010，3，1： | 1 |
| 8 | Cystatin C :an emer- ging biomarker in cardiovascular disease 显示文摘 | Angelidis C Deftereos S Giannopoulos G | 2013 | Curr Top Med Chem2013，13，2： | 1 |
| 9 | Cystatin C:an emerging biomarker in cardiovascular disease显示文摘 | Angelidis C Deftereos S Giannopoulos G | 2013 | Curr Top Med Chem2013，13，2： | 1 |
| 10 | Correlation of plasma B-type natriuretic peptide with shunt volume in children with congenital heart disease involving left-to-right shunt 显示文摘 | Kavga M Varlamis G Giannopoulos A | 2013 | Hellenic J Cardiol2013，54，3： | 1 |
| 11 | Cystatin C: an emerging biomarker in cardiovascular disease 显示文摘 | Angelidis C Deftereos S Giannopoulos G | 2013 | Curr Top Med Chern2013，13，2： | 1 |
| 12 | Heart rate lowering by inhibition of the pacemaker current: a new therapeutic perspective in cardiovascular disease显示文摘 | Dilaveris P Giannopoulos G Synetos A | 2006 | Cardiovasc Hematol Agents Med Chem2006，4，4： | 1 |
| 13 | The role of renin angiotensin system blockade in the treatment of atrial fibrillation显示文摘 | Dilaveris P Giannopoulos G Synetos A | 2005 | Curr Drug Targets Cardiovase Haematol Disord2005，5，5： | 1 |
| 14 | CLimate Impacts on Myocardial infarction deaths in the Athens TErritory: the CLIMATE study显示文摘 | Dilaveris P Synetos A Giannopoulos G | 2006 | Heart2006，92，12： | 1 |
| 15 | Clinical determi-nants of electrocardiographic and spatial vectorcardiographic de-scriptors of ventricular repolarization in healthy children显示文摘 | Dilaveris P Roussos D Giannopoulos G | 2011 | Annals of Noninvasive Electrocardiology2011，，01： | 1 |
| 16 | The expression of ma-trix metalloproteinases-2 and-9 and their tissue inhibitor 2 in pan-creatic ductal and ampullary carcinoma and their relation to angio-genesis and clinicopathological parameters显示文摘 | Giannopoulos G Pavlakis K Parasi A | | 0，，3： | 1 |
| 17 | Cystatin C : an e- merging biomarker in cardiovascular disease 显示文摘 | Angelidis C Deftereos S Giannopoulos G | 2013 | Curr Top Med Chem2013，13，2： | 1 |
| 18 | The expression of matrix metalloproteinases-2 and-9 and their tissue inhibitor 2in pancreatic ductal and ampullary carcinoma and their relation to angiogenesisand clinicopathological parameters显示文摘 | Giannopoulos G Pavlakis K Parasi A | 2008 | Anticancer Res2008，28，3： | 1 |
| 19 | Climate impacts on Myocardial infarction deaths in the athens territory: the CLIMATE study显示文摘 | DILAVERIS P SYNETOS A GIANNOPOULOS G | 2006 | Heart2006，92，12： | 1 |
| 20 | The expressionof matrixmetalloproteinases-2and-9and their tissue inhibitor2in pancreatic ductal and ampullary carcinoma and theirrelation to angiogenesis and clinicopathological parameters显示文摘 | Giannopoulos G Pavlakis K Parasi A | 2008 | Anticancer Res2008，28，3： | 1 |
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